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Autor:
Karin G. Stenkula, Olga Göransson, Franziska Kopietz, Jurga Laurencikiene, Johanna Säll, Björn Hansson, Mikael Ekelund, Eva Degerman, Wilhelm Linder, Annie M. L. Pettersson, Florentina Negoita
Publikováno v:
Cellular Signalling. 55:73-80
Aims/hypothesis Salt-inducible kinase 2 (SIK2) is downregulated in adipose tissue from obese or insulin-resistant individuals and inhibition of SIK isoforms results in reduced glucose uptake and insulin signalling in adipocytes. However, the regulati
Autor:
Michelle Chiu, Nathaniel W. York, De-Ann M. Pillers, Bikash R. Pattnaik, Patrick Halbach, Ian M. Bird
Publikováno v:
Cellular Signalling. 37:93-102
Oxytocin (OXT) is a neuropeptide that activates the oxytocin receptor (OXTR), a rhodopsin family G-protein coupled receptor. Our localization of OXTR to the retinal pigment epithelium (RPE), in close proximity to OXT in the adjacent photoreceptor neu
Publikováno v:
Cellular Signalling. 28:643-651
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that can regulate various physiological and pathological processes. The expression of S1P has been detected in human follicular fluid. In addition, two S1P receptors, S1P1 and S1P3, are expres
Publikováno v:
Cellular Signalling. 28:109-116
Aims The role of different vascular subtypes of phosphodiesterases (PDE) in cGMP compartmentalization was evaluated in human smooth muscle cells. Methods and results To understand how the cGMP conveys different information we infected smooth muscle c
Publikováno v:
Cellular Signalling. 28:204-213
Parathyroid hormone (PTH) is secreted from the parathyroid glands in response to low plasma calcium levels. Besides its classical actions on bone and kidney, PTH may have other important effects, including metabolic effects, as suggested for instance
Autor:
Surleen Kaur, G. Anjali, Ruchi Lakra, Jyoti Taneja, Alka Kriplani, Rita Singh, Tulsidas G. Shrivastav, Anjali Nagendra, M. Gouri Devi, Neena Malhotra, Gaganjot Singh Kalsey
Publikováno v:
Cellular Signalling. 27:2452-2466
Follicle stimulating hormone (FSH) plays a central role in growth and differentiation of ovarian follicles. A plethora of information exists on molecular aspects of FSH responses but little is known about the mechanisms involved in its cross-talk wit
Publikováno v:
Cellular Signalling. 27:1533-1543
Sestrin2 (SESN2) regulates redox-homeostasis and apoptosis in response to various stresses. Although the antioxidant effects of SESN2 have been well established, the roles of SESN2 in mitochondrial function and metabolic stress have not yet been eluc
Autor:
Keven R. Johnson, Andrei V. Karginov, Randal A. Skidgel, John P. O'Bryan, Brian T. Burmeister, Graeme K. Carnegie, Li Wang, George S. Baillie
Publikováno v:
Cellular Signalling. 27:908-922
Hypertrophy increases the risk of heart failure and arrhythmia. Prevention or reversal of the maladaptive hypertrophic phenotype has thus been proposed to treat heart failure. Chronic β-adrenergic receptor (β-AR) stimulation induces cardiomyocyte h
Autor:
Xiang Jie Kong, Xiao Qiang Qian, Ding Xu, Jun Hao Liang, Jun Qi, Jian Kang, Liu Jian Duan, Tao Huang
Publikováno v:
Cellular Signalling. 27:215-227
Bladder outlet obstruction (BOO) evokes urinary bladder wall remodeling significantly, including the phenotype shift of bladder smooth muscle cells (BSMCs) where transforming growth factor-beta1 (TGF-β1) plays a pivotal role given the emerging funct
Autor:
Lirong Lin, Jun Liu, Jun Zhan, Xiangmei Chen, Bengang Huo, Jie Yang, Kun Huang, Yani He, Jurong Yang, Guangyan Cai
Publikováno v:
Cellular Signalling. 26:110-121
Premature senescence is a key process in the progression of diabetic nephropathy (DN). In our study, we hypothesized that receptors for advanced glycation end-products (RAGE) mediate endoplasmic reticulum (ER) stress to induce premature senescence vi