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Publikováno v:
Cell Signal
Striated myocytes compose about half of the cells of the heart, while contributing the majority of the heart's mass and volume. In response to increased demands for pumping power, including in diseases of pressure and volume overload, the contractile
Publikováno v:
Cellular Signalling. 28:643-651
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that can regulate various physiological and pathological processes. The expression of S1P has been detected in human follicular fluid. In addition, two S1P receptors, S1P1 and S1P3, are expres
Autor:
Ruo-Lan Xiang, Xia Yi, Kyungpyo Park, Yan Zhang, Jing Li, Jing-Yan Han, Li-Ling Wu, Mei Mei, Xin Cong, Guang-Yan Yu
Publikováno v:
Cellular Signalling. 27:1915-1927
TNF-α plays an important role in the pathogenesis of salivary inflammatory diseases. Salivary dysfunction, which leads to impaired saliva secretion, can be caused by TNF-α-induced disrupted epithelial barrier. However, the signaling mechanism invol
Autor:
Eric D. Tang, Cun-Yu Wang
Publikováno v:
Cellular Signalling. 27:836-840
The Hippo pathway is an evolutionarily conserved regulator of normal and oncogenic growth. Engagement of Hippo pathway signaling results in the inactivation of the transcriptional coactivator YAP by preventing its nuclear entry. The mechanisms underl
Publikováno v:
Cellular Signalling. 26:2757-2764
Nuclear receptor-binding SET domain-containing protein 1 (NSD1) has been proved to act as a histone methyltransferase and a transcription co-factor to regulate gene expression. However, the role of NSD1 in oxidative stress remains poorly understood.
Publikováno v:
Cellular Signalling. 26:1445-1455
Signal Transducers and Activator of Transcription-3 (STAT3) are latent transcription factors that are regulated by post-translational modifications (PTMs) in response to cellular activation by the IL-6 superfamily of cytokines to regulate cell cycle
Publikováno v:
Cellular signalling. 31
Tubulointerstitial fibrosis (TIF) plays an important role in the progression of renal fibrosis in diabetic nephropathy (DN). Accumulating evidence supports a crucial effect of early growth response factor 1 (Egr1) on renal fibrosis in DN, but the und
Publikováno v:
Cellular Signalling. 25:214-228
Interleukin-1 (IL-1) induces the internalization of its cognate receptor from the plasma membrane. However, it has remained elusive as to how this mechanism affects the IL-1-induced signal transduction. In this study, we used small-molecule inhibitor
Publikováno v:
Cellular Signalling. 24:2297-2306
Background β2-Adrenergic receptor (β2-AR) signaling activated by the agonist clenbuterol is important in the metabolism of muscle and adipose cells. Additionally, the significant role of histone demethylase JHDM2a in regulating metabolic gene expre
Publikováno v:
Cellular Signalling. 20:1769-1779
The neuron-specific potassium-chloride cotransporter 2 (KCC2) plays a crucial role, by controlling chloride extrusion, in the development and maintenance of inhibitory neurotransmission. Although it is now well established that activity-dependent mec