Zobrazeno 1 - 10
of 23
pro vyhledávání: ''
Autor:
Neema S. Patel, Reagan Farmer, Angelo Sarmiento, Michy P. Kelly, Steven D. Burbano, Abigail J. Smith
Publikováno v:
Cell Signal
Many studies implicate altered cyclic nucleotide signaling in the pathophysiology of major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SCZ). As such, we explored how phosphodiesterases 2A (PDE2A) and 10A (PDE10A)-enzymes tha
Autor:
Michy P. Kelly
Publikováno v:
Cellular Signalling. 42:281-291
Deficits in brain function that are associated with aging and age-related diseases benefit very little from currently available therapies, suggesting a better understanding of the underlying molecular mechanisms is needed to develop improved drugs. H
Autor:
Peter Storz, Alicia K. Fleming
Publikováno v:
Cellular Signalling. 40:1-9
Protein Kinase C isoforms have been implicated in regulating multiple processes within the healthy pancreas. Moreover, their dysregulation contributes to all aspects of pancreatic disease. In this review, with a focus on acinar, ductal, and islet cel
Autor:
Michelle Chiu, Nathaniel W. York, De-Ann M. Pillers, Bikash R. Pattnaik, Patrick Halbach, Ian M. Bird
Publikováno v:
Cellular Signalling. 37:93-102
Oxytocin (OXT) is a neuropeptide that activates the oxytocin receptor (OXTR), a rhodopsin family G-protein coupled receptor. Our localization of OXTR to the retinal pigment epithelium (RPE), in close proximity to OXT in the adjacent photoreceptor neu
Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival
Publikováno v:
Cellular Signalling. 32:85-92
About 40,000 American women die from metastatic breast cancer each year despite advancements in treatment. Approximately, 15% of breast cancers are triple-negative for estrogen receptor, progesterone receptor, and HER2. Triple-negative cancer is char
Publikováno v:
Cellular Signalling. 28:1789-1805
The peptide hormones Insulin-like growth factor-1 (IGF1) and leptin mediate a myriad of biological effects - both in the peripheral and central nervous systems. The transcription of these two hormones is regulated by the transcription factor C/EBPα,
Autor:
Yutaro Obara, Hiromi Ito, Norimichi Nakahata, Beth A. Habecker, Maho Takahashi, Ryusuke Nagasawa, Yoshihiko Tomita, Wataru Nemoto, Philip J.S. Stork, Kuniaki Ishii, Michael J. Pellegrino, Osamu Ichiyanagi
Publikováno v:
Cellular Signalling. 28:177-189
Extracellular signal-regulated kinases (ERKs) play important roles in proliferation, differentiation and gene expression. In our previous study, we demonstrated that both ERK5 and ERK1/2 were responsible for neurite outgrowth and tyrosine hydroxylase
Publikováno v:
Cellular Signalling. 27:2389-2400
Phosphatidylinositol-3-kinase (PI3K) is a key regulator of diverse biological processes including cell proliferation, migration, survival, and differentiation. While a role of PI3K in chondrocyte differentiation has been suggested, its precise mechan
Autor:
Keven R. Johnson, Andrei V. Karginov, Randal A. Skidgel, John P. O'Bryan, Brian T. Burmeister, Graeme K. Carnegie, Li Wang, George S. Baillie
Publikováno v:
Cellular Signalling. 27:908-922
Hypertrophy increases the risk of heart failure and arrhythmia. Prevention or reversal of the maladaptive hypertrophic phenotype has thus been proposed to treat heart failure. Chronic β-adrenergic receptor (β-AR) stimulation induces cardiomyocyte h
Publikováno v:
Cellular Signalling
Platelets store and secrete the chemokine stromal cell-derived factor (SDF)-1α upon platelet activation, but the ability of platelet-derived SDF-1α to signal in an autocrine/paracrine manner mediating functional platelet responses relevant to throm