Zobrazeno 1 - 10
of 22
pro vyhledávání: ''
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1073-1092 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1073-1092 (2021)
Background & Aims Epithelial cells form a monolayer at mucosal surface that functions as a highly selective barrier. Lysophosphatidic acid (LPA) is a bioactive lipid that elicits a broad range of biological effects via cognate G protein-coupled recep
Autor:
Guan Huei Lee, Iyer G. Shridhar, Yin Huei Pang, Yi Ting Lim, Seng Gee Lim, Daniel Q. Huang, Wan Xin Tan, Mark D. Muthiah, Lei Zhou, Glenn Kunnath Bonney, Pierce K. H. Chow, Alfred Wei Chieh Kow, Gwyneth Soon, Aileen Wee, Yock Young Dan, Halisah Jumat
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1313-1325 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Hepatocellular carcinoma (HCC) arises in a cirrhotic, pro-angiogenic microenvironment. Inhibiting angiogenesis is a key mode of action of multikinase inhibitors and current non-cirrhotic models are unable to predict treatment respon
Autor:
Yang Yang, Yimin Jia, Yun Hu, Bo Sun, Yue Feng, Haibo Dong, Xiang Zhong, Longfei Jia, Ruqian Zhao
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 839-856 (2021)
Background and Aims Transforming growth factor β1 (TGF-β1) secreted from activated Kupffer cells (KC) promotes the progression of nonalcoholic steatohepatitis (NASH) to liver fibrosis. N6-methyladenosine (m6A) RNA modification participates in vario
Autor:
Iulia Oancea, Andy Wu, Michael A. McGuckin, Sumaira Z. Hasnain, Rabina Giri, John D. Hooper, Veronika Schreiber, Brett C McWhinney, Julie M. Davies, Jakob Begun, Yonghua Sheng, David P. Fairlie, Saleh Y. Alabbas, Gregor Kijanka, Yaowu He, Ramya Movva, Andrew J. Lucke, Timothy H. Florin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 33-53 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD). Abnormal Wnt/β-catenin
Autor:
Otto Savolainen, Johanna Sundin, Stefan Isaksson, Hans Strid, Lena Öhman, Lujain Maasfeh, Maria K. Magnusson, Anetta Härtlova, Georgios Mavroudis
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1415-1432 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Intestinal macrophages adopt a hyporesponsive phenotype through education by local signals. Lack of proper macrophage maturation in patients with ulcerative colitis (UC) in remission may initiate gut inflammation. The aim, therefore
Autor:
Woosook Kim, Feijing Wu, Leah B. Zamechek, Timothy C. Wang, Ruth A. White, Jonathan S. LaBella, Osmel Companioni Nápoles, Bryana R. Belin, Zhengyu Jiang, Giovanni Valenti, Tuo Ruan, Yosuke Ochiai, Na Fu, Ermanno Malagola
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1119-1138 (2021)
Background & Aims Histidine decarboxylase (HDC), the histamine-synthesizing enzyme, is expressed in a subset of myeloid cells but also marks quiescent myeloid-biased hematopoietic stem cells (MB-HSCs) that are activated upon myeloid demand injury. Ho
Autor:
Evelyn Seelow, Eberhard Hildt, Denna Tabari, Kathrin Woytinek, David Heiler Martín, Catharina Scholl, Julia C. Stingl, Mira Choi, Benjamin Schmidt, Mirco Glitscher
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 159-180 (2021)
Cellular and Molecular Gastroenterology and Hepatology : CMGH 12, 159-180 (2021). doi:10.1016/j.jcmgh.2021.02.002
Cellular and Molecular Gastroenterology and Hepatology, 12(1):159-180
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology : CMGH 12, 159-180 (2021). doi:10.1016/j.jcmgh.2021.02.002
Cellular and Molecular Gastroenterology and Hepatology, 12(1):159-180
Cellular and Molecular Gastroenterology and Hepatology
Background and aims The Hepatitis E virus hijacks the endosomal system for its release. These structures are highly dependent on cholesterol. Hence, this study investigates the impact of HEV on cholesterol-metabolism, the effect of intracellular chol
Autor:
Liuyi Hao, Haibo Dong, Xinguo Sun, Zhanxiang Zhou, Ruichao Yue, Wei Guo, Wenliang Zhang, Wei Zhong
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 793-811 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Aryl hydrocarbon receptor (AhR) is a liver-enriched xenobiotic receptor that plays important role in detoxification response in liver. This study aimed to investigate how AhR signaling may impact the pathogenesis of alcohol-related
Autor:
Junya Kawasoe, Yusuke Okamura, Tatsuaki Tsuruyama, Tetsuya Tajima, Shinji Uemoto, Ichiro Tamaki, Jiro Kusakabe, Hidetaka Miyauchi, Tatsuya Okamoto, Yi Wang, Xiangdong Zhao, Koichiro Hata
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1351-1367 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Acute liver failure (ALF) is a life-threatening condition with limited treatment alternatives. ALF pathogenesis seemingly involves the complement system. However, no complement-targeted intervention has been clinically applied. In t
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 729-746 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 729-746 (2020)
BackgroundVitamin D exerts regulatory roles via vitamin D receptor (VDR) in mucosal immunity, host defense, and inflammation involving host factors and microbiome. Human Vdr gene variation shapes the microbiome and VDR deletion leads to dysbiosis. Lo