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pro vyhledávání: ''
Autor:
Guan Huei Lee, Iyer G. Shridhar, Yin Huei Pang, Yi Ting Lim, Seng Gee Lim, Daniel Q. Huang, Wan Xin Tan, Mark D. Muthiah, Lei Zhou, Glenn Kunnath Bonney, Pierce K. H. Chow, Alfred Wei Chieh Kow, Gwyneth Soon, Aileen Wee, Yock Young Dan, Halisah Jumat
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1313-1325 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Hepatocellular carcinoma (HCC) arises in a cirrhotic, pro-angiogenic microenvironment. Inhibiting angiogenesis is a key mode of action of multikinase inhibitors and current non-cirrhotic models are unable to predict treatment respon
Autor:
Iulia Oancea, Andy Wu, Michael A. McGuckin, Sumaira Z. Hasnain, Rabina Giri, John D. Hooper, Veronika Schreiber, Brett C McWhinney, Julie M. Davies, Jakob Begun, Yonghua Sheng, David P. Fairlie, Saleh Y. Alabbas, Gregor Kijanka, Yaowu He, Ramya Movva, Andrew J. Lucke, Timothy H. Florin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 33-53 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD). Abnormal Wnt/β-catenin
Autor:
Otto Savolainen, Johanna Sundin, Stefan Isaksson, Hans Strid, Lena Öhman, Lujain Maasfeh, Maria K. Magnusson, Anetta Härtlova, Georgios Mavroudis
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1415-1432 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Intestinal macrophages adopt a hyporesponsive phenotype through education by local signals. Lack of proper macrophage maturation in patients with ulcerative colitis (UC) in remission may initiate gut inflammation. The aim, therefore
Autor:
Woosook Kim, Feijing Wu, Leah B. Zamechek, Timothy C. Wang, Ruth A. White, Jonathan S. LaBella, Osmel Companioni Nápoles, Bryana R. Belin, Zhengyu Jiang, Giovanni Valenti, Tuo Ruan, Yosuke Ochiai, Na Fu, Ermanno Malagola
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1119-1138 (2021)
Background & Aims Histidine decarboxylase (HDC), the histamine-synthesizing enzyme, is expressed in a subset of myeloid cells but also marks quiescent myeloid-biased hematopoietic stem cells (MB-HSCs) that are activated upon myeloid demand injury. Ho
Autor:
Evelyn Seelow, Eberhard Hildt, Denna Tabari, Kathrin Woytinek, David Heiler Martín, Catharina Scholl, Julia C. Stingl, Mira Choi, Benjamin Schmidt, Mirco Glitscher
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 159-180 (2021)
Cellular and Molecular Gastroenterology and Hepatology : CMGH 12, 159-180 (2021). doi:10.1016/j.jcmgh.2021.02.002
Cellular and Molecular Gastroenterology and Hepatology, 12(1):159-180
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology : CMGH 12, 159-180 (2021). doi:10.1016/j.jcmgh.2021.02.002
Cellular and Molecular Gastroenterology and Hepatology, 12(1):159-180
Cellular and Molecular Gastroenterology and Hepatology
Background and aims The Hepatitis E virus hijacks the endosomal system for its release. These structures are highly dependent on cholesterol. Hence, this study investigates the impact of HEV on cholesterol-metabolism, the effect of intracellular chol
Autor:
Junya Kawasoe, Yusuke Okamura, Tatsuaki Tsuruyama, Tetsuya Tajima, Shinji Uemoto, Ichiro Tamaki, Jiro Kusakabe, Hidetaka Miyauchi, Tatsuya Okamoto, Yi Wang, Xiangdong Zhao, Koichiro Hata
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1351-1367 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Acute liver failure (ALF) is a life-threatening condition with limited treatment alternatives. ALF pathogenesis seemingly involves the complement system. However, no complement-targeted intervention has been clinically applied. In t
Autor:
Nicolas Esquerre, Dominique Bihan, Alana Schick, Yasmin Nasser, Manon Defaye, Fernando A. Vicentini, Lilian Basso, Keith A. Sharkey, Christophe Altier, Simon A. Hirota, Ian A. Lewis, Nina L. Cluny, Humberto Jijon, Markus B. Geuking
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 225-244 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 225-244 (2020)
Background & Aims Despite achieving endoscopic remission, more than 20% of inflammatory bowel disease patients experience chronic abdominal pain. These patients have increased rectal transient receptor potential vanilloid-1 receptor (TRPV1) expressio
Autor:
Hamid M. Said, Jonathan Skupsky, Michael D. Cahalan, Manando Nakasaki, Subrata Sabui, Michael Hwang
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 4, Pp 557-567 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 9, iss 4
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 9, iss 4
Background & Aims Biotin is a water-soluble vitamin that is indispensable for human health. Biotin deficiency can cause failure-to-thrive, immunodeficiency, alopecia, dermatitis, and conjunctivitis. We previously reported that biotin deficiency also
Autor:
Dan Xu, Jia Nie, Feng Liu, Dandan Jia, Yue Zheng, Xianlin Han, Xueling Liu, Jun Zhang, Xiaoyang Zhang, Jianing Wang, Haoran Sun, Yuguang Shi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 763-781 (2019)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Obesity promotes the development of nonalcoholic fatty liver diseases (NAFLDs), yet not all obese patients develop NAFLD. The underlying causes for this discrepancy remain elusive. LPGAT1 is an acyltransferase that catalyzes the rem
Autor:
Jun Yan, Ding Ai, Chunjiong Wang, Chenji Ye, Wenli Liu, Yajin Liu, Hua Wang, Qian Cheng, Zhengsheng Zou, Jing Huang, Yi Zhu, Qi Li, Liu Yao, Xuejiao Zhang
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 211-231 (2019)
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 211-231 (2019)
Background & Aims Nonalcoholic steatohepatitis (NASH) is an increasingly prevalent nonalcoholic fatty liver disease, characterized by inflammatory cell infiltration and hepatocellular damage. Mammalian target of rapamycin complex 1 (mTORC1) has been