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pro vyhledávání: ''
Autor:
Iulia Oancea, Andy Wu, Michael A. McGuckin, Sumaira Z. Hasnain, Rabina Giri, John D. Hooper, Veronika Schreiber, Brett C McWhinney, Julie M. Davies, Jakob Begun, Yonghua Sheng, David P. Fairlie, Saleh Y. Alabbas, Gregor Kijanka, Yaowu He, Ramya Movva, Andrew J. Lucke, Timothy H. Florin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 33-53 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD). Abnormal Wnt/β-catenin
Autor:
Woosook Kim, Feijing Wu, Leah B. Zamechek, Timothy C. Wang, Ruth A. White, Jonathan S. LaBella, Osmel Companioni Nápoles, Bryana R. Belin, Zhengyu Jiang, Giovanni Valenti, Tuo Ruan, Yosuke Ochiai, Na Fu, Ermanno Malagola
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1119-1138 (2021)
Background & Aims Histidine decarboxylase (HDC), the histamine-synthesizing enzyme, is expressed in a subset of myeloid cells but also marks quiescent myeloid-biased hematopoietic stem cells (MB-HSCs) that are activated upon myeloid demand injury. Ho
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 729-746 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 729-746 (2020)
BackgroundVitamin D exerts regulatory roles via vitamin D receptor (VDR) in mucosal immunity, host defense, and inflammation involving host factors and microbiome. Human Vdr gene variation shapes the microbiome and VDR deletion leads to dysbiosis. Lo
Autor:
Nicolas Esquerre, Dominique Bihan, Alana Schick, Yasmin Nasser, Manon Defaye, Fernando A. Vicentini, Lilian Basso, Keith A. Sharkey, Christophe Altier, Simon A. Hirota, Ian A. Lewis, Nina L. Cluny, Humberto Jijon, Markus B. Geuking
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 225-244 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 225-244 (2020)
Background & Aims Despite achieving endoscopic remission, more than 20% of inflammatory bowel disease patients experience chronic abdominal pain. These patients have increased rectal transient receptor potential vanilloid-1 receptor (TRPV1) expressio
Autor:
Craig J. McClain, Manicka V. Vadhanam, Hridgandh Donde, Shirish Barve, Sanjay Srivastava, Leila Gobejishvili, Swati Joshi-Barve, Smita Ghare, Jingwen Zhang, Pawel Lorkiewicz
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 4, Pp 569-585 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Ethanol-mediated down-regulation of carnitine palmitoyltransferase-1 (CPT-1A) gene expression plays a major role in the development of hepatic steatosis; however, the underlying mechanisms are not completely elucidated. Tributyrin, a butyrate prodrug
Autor:
Hamid M. Said, Jonathan Skupsky, Michael D. Cahalan, Manando Nakasaki, Subrata Sabui, Michael Hwang
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 4, Pp 557-567 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 9, iss 4
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 9, iss 4
Background & Aims Biotin is a water-soluble vitamin that is indispensable for human health. Biotin deficiency can cause failure-to-thrive, immunodeficiency, alopecia, dermatitis, and conjunctivitis. We previously reported that biotin deficiency also
Autor:
Naoki Minami, Hisanori Horiuchi, Kohei Wagatsuma, Daisuke Hirayama, Ryutaro Shirakawa, Tomoya Iida, Seiichi Hirota, Hiroki Ikeuchi, Minoru Matsuura, Hiroshi Nakase, Kentaro Kawakami, Masanori Nojima, Kanna Nagaishi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 2, Pp 277-293 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Ral guanosine triphosphatase–activating protein α2 (RalGAPα2) is the major catalytic subunit of the negative regulators of the small guanosine triphosphatase Ral, a member of the Ras subfamily. Ral regulates tumorigenesis and in
Autor:
Dan Xu, Jia Nie, Feng Liu, Dandan Jia, Yue Zheng, Xianlin Han, Xueling Liu, Jun Zhang, Xiaoyang Zhang, Jianing Wang, Haoran Sun, Yuguang Shi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 763-781 (2019)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Obesity promotes the development of nonalcoholic fatty liver diseases (NAFLDs), yet not all obese patients develop NAFLD. The underlying causes for this discrepancy remain elusive. LPGAT1 is an acyltransferase that catalyzes the rem
Autor:
Nicolai Lehnert, Dhiman Maitra, Stephen W. Ragsdale, Laure Rittié, M. Bishr Omary, Alexey I. Nesvizhskii, Haoming Zhang, Matthew W. Wolf, Harald Herrmann, Venkatesha Basrur, Rani Richardson, Yoichi Osawa, Eric L. Carter
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 4, Pp 659-682.e1 (2019)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Porphyrias are caused by porphyrin accumulation resulting from defects in the heme biosynthetic pathway that typically lead to photosensitivity and possible end-stage liver disease with an increased risk of hepatocellular carcinoma.
Autor:
Massimo Federici, Francesca Ceccherini-Silberstein, Irene Marafini, Thomas T. MacDonald, Alfredo Colantoni, Antonio Di Grazia, Giovanni Monteleone, Vincenzo Dinallo, Maria Mavilio, Carmine Stolfi, Claudia Alteri, Federica Laudisi, Francesca Guerrieri, Davide Di Fusco, Angela Ortenzi, Ivan Monteleone
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 2, Pp 457-473 (2019)
Background & Aims: Food additives, such as emulsifiers, stabilizers, or bulking agents, are present in the Western diet and their consumption is increasing. However, little is known about their potential effects on intestinal homeostasis. In this stu