Zobrazeno 1 - 10
of 79
pro vyhledávání: ''
Publikováno v:
Cells
Cells, Vol 10, Iss 3075, p 3075 (2021)
Volume 10
Issue 11
Cells, Vol 10, Iss 3075, p 3075 (2021)
Volume 10
Issue 11
Reversible phosphorylation has emerged as an important mechanism for regulating proteasome function in various physiological processes. Essentially all proteasome phosphorylations characterized thus far occur on proteasome holoenzyme or subcomplexes
Autor:
Ioanna V. Papathanasiou, Zozo Outskouni, Varvara Trachana, George Koliakos, Maria Satra, Andreas Goutas
Publikováno v:
Cells
Volume 10
Issue 11
Cells, Vol 10, Iss 2939, p 2939 (2021)
Volume 10
Issue 11
Cells, Vol 10, Iss 2939, p 2939 (2021)
We recently reported that the inability of osteoarthritic (OA) chondrocytes to repair oxidative stress (OS) induced DNA damage is linked to Cav-1 overexpression/improper localization. We speculated that the senescent status of OA cells was responsibl
Publikováno v:
Cells
Volume 10
Issue 11
Cells, Vol 10, Iss 3172, p 3172 (2021)
Volume 10
Issue 11
Cells, Vol 10, Iss 3172, p 3172 (2021)
Mitochondrial morphology and motility (mitochondrial dynamics) play a major role in the proper functioning of distant synapses. In Huntington’s disease (HD), mitochondria become fragmented and less motile, but the mechanisms leading to these change
Autor:
Shyam Kumar Ramakrishnan, Yash T Katakia, Syamantak Majumder, Sumukh Thakar, Niyati Pandya Thakkar
Publikováno v:
Cells
Volume 10
Issue 10
Cells, Vol 10, Iss 2548, p 2548 (2021)
Volume 10
Issue 10
Cells, Vol 10, Iss 2548, p 2548 (2021)
Epigenetic mechanisms have emerged as one of the key pathways promoting diabetes-associated complications. Herein, we explored the role of enhancer of zeste homolog 2 (EZH2) and its product histone 3 lysine 27 trimethylation (H3K27me3) in high glucos
Autor:
Kou Yonemaru, Naoki Shinojima, Kunimasa Ohta, Hideyuki Saito, Shunsuke Miyake, Hirofumi Jono, Naofumi Ito, Michiko Yamaoka, Yuki Ito, Akari Kuwano, Ayumi Kanemaru, Shota Uchino, Yuki Shirakawa, Takuichiro Hide, Akitake Mukasa
Publikováno v:
Cells
Cells, Vol 10, Iss 2970, p 2970 (2021)
Volume 10
Issue 11
Cells, Vol 10, Iss 2970, p 2970 (2021)
Volume 10
Issue 11
Although glioblastoma (GBM) stem-like cells (GSCs), which retain chemo-radio resistance and recurrence, are key prognostic factors in GBM patients, the molecular mechanisms of GSC development are largely unknown. Recently, several studies revealed th
Publikováno v:
Cells
Cells, Vol 10, Iss 1800, p 1800 (2021)
Volume 10
Issue 7
Cells, Vol 10, Iss 1800, p 1800 (2021)
Volume 10
Issue 7
Cancer cells need a constant supply of nutrients. SLC6A14, an amino acid transporter B0,+ (ATB0,+) that is upregulated in many cancers, transports all but acidic amino acids. In its exit from the endoplasmic reticulum (ER), it is recognized by the SE
Publikováno v:
Cells
Cells, Vol 10, Iss 1522, p 1522 (2021)
Cells, Vol 10, Iss 1522, p 1522 (2021)
BECLIN1 is a well-established regulator of autophagy, a process essential for mammalian survival. It functions in conjunction with other proteins to form Class III Phosphoinositide 3-Kinase (PI3K) complexes to generate phosphorylated phosphatidylinos
Autor:
Caroline Arnold, Eda Demirel, Nina Wettschureck, Markus Hecker, Marius Andreas Jäger, Thomas Korff, Hanna Kuk, Carsten Sticht, Rui Li, Jaspal Garg
Publikováno v:
Cells
Volume 10
Issue 7
Cells, Vol 10, Iss 1748, p 1748 (2021)
Volume 10
Issue 7
Cells, Vol 10, Iss 1748, p 1748 (2021)
The regulator of G-protein signaling 5 (RGS5) acts as an inhibitor of Gαq/11 and Gαi/o activity in vascular smooth muscle cells (VSMCs), which regulate arterial tone and blood pressure. While RGS5 has been described as a crucial determinant regulat
Autor:
Troy A Kervin, Michael Overduin
Publikováno v:
Cells
Volume 10
Issue 5
Cells, Vol 10, Iss 1205, p 1205 (2021)
Volume 10
Issue 5
Cells, Vol 10, Iss 1205, p 1205 (2021)
The genetic code that dictates how nucleic acids are translated into proteins is well known, however, the code through which proteins recognize membranes remains mysterious. In eukaryotes, this code is mediated by hundreds of membrane readers that re
Publikováno v:
Cells
Cells, Vol 10, Iss 1342, p 1342 (2021)
Cells, Vol 10, Iss 1342, p 1342 (2021)
FGFR (fibroblast growth factor receptor) signaling controls fundamental processes in embryonic, fetal and adult human life. The magnitude, duration, and location of FGFR signaling must be strictly controlled in order to induce the correct biological