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Publikováno v:
Cells; Volume 11; Issue 9; Pages: 1478
Bitter taste receptors (T2Rs) are G protein-coupled receptors (GPCRs) expressed in various cell types including ciliated airway epithelial cells and macrophages. T2Rs in these two airway innate immune cell types are activated by bitter products, incl
Autor:
Niamh C. Williams, Vittoria Infantino, Simona Todisco, Anna Santarsiero, Giulio De Stefano, Luke A. J. O'Neill, Anna De Grassi, Ciro Leonardo Pierri, Paolo Convertini, Dominga Iacobazzi
Publikováno v:
Cells
Volume 10
Issue 11
Cells, Vol 10, Iss 2962, p 2962 (2021)
Volume 10
Issue 11
Cells, Vol 10, Iss 2962, p 2962 (2021)
Macrophage stimulation by pathogen-associated molecular patterns (PAMPs) like lipopolysaccharide (LPS) or lipoteichoic acid (LTA) drives a proinflammatory phenotype and induces a metabolic reprogramming to sustain the cell’s function. Nevertheless,
Autor:
Elena B. Tikhonova, Xiongwei Zhu, Fanpeng Zhao, Kristen R. Baca, Andrey L. Karamyshev, Sarah M. Hernandez
Publikováno v:
Cells
Volume 10
Issue 10
Cells, Vol 10, Iss 2792, p 2792 (2021)
Volume 10
Issue 10
Cells, Vol 10, Iss 2792, p 2792 (2021)
Parkinson’s disease (PD) is a neurodegenerative disorder classified by the loss of dopaminergic neurons in the substantia nigra pars compacta, the region of the brain that is responsible for motor control. Surviving neurons in this region contain a
Autor:
Stanislava Popova, Prabesh Bhattarai, Richard Mayeux, Caghan Kizil, Sanjeev Sariya, Yixin Zhang, Mehmet Ilyas Cosacak, Giuseppe Tosto, Tohid Siddiqui
Publikováno v:
Cells
Volume 10
Issue 10
Cells 10(10), 2748 (2021). doi:10.3390/cells10102748 special issue: "Neurogenesis and Regeneration in Teleost Central Nervous System"
Cells, Vol 10, Iss 2748, p 2748 (2021)
Volume 10
Issue 10
Cells 10(10), 2748 (2021). doi:10.3390/cells10102748 special issue: "Neurogenesis and Regeneration in Teleost Central Nervous System"
Cells, Vol 10, Iss 2748, p 2748 (2021)
Neurogenesis decreases in Alzheimer’s disease (AD) patients, suggesting that restoring the normal neurogenic response could be a disease modifying intervention. To study the mechanisms of pathology-induced neuro-regeneration in vertebrate brains, z
Publikováno v:
Cells
Volume 10
Issue 10
Cells, Vol 10, Iss 2703, p 2703 (2021)
Volume 10
Issue 10
Cells, Vol 10, Iss 2703, p 2703 (2021)
Exposure to ubiquitous endocrine-disrupting chemicals (EDCs) is a major public health concern. We analyzed the physiological impact of the EDC, di-2-ethylhexyl phthalate (DEHP), and found that its metabolite, mono-2-ethylhexyl phthalate (MEHP), had s
Autor:
Hong-Mei Li, Michael N. Teng, MengJie Hu, Lora M. Starrs, John Mills, David A. Jans, Kim C. Tran, Reena Ghildyal
Publikováno v:
Cells
Volume 10
Issue 10
Cells, Vol 10, Iss 2786, p 2786 (2021)
Volume 10
Issue 10
Cells, Vol 10, Iss 2786, p 2786 (2021)
The morbidity and mortality caused by the globally prevalent human respiratory pathogen respiratory syncytial virus (RSV) approaches that world-wide of influenza. We previously demonstrated that the RSV matrix (M) protein shuttles, in signal-dependen
Publikováno v:
Cells
Cells, Vol 10, Iss 2603, p 2603 (2021)
Cells, Vol 10, Iss 2603, p 2603 (2021)
Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of
Autor:
Mallika Valapala, Hsuan-Yeh Pan
Publikováno v:
Cells
Cells, Vol 10, Iss 2504, p 2504 (2021)
Volume 10
Issue 10
Cells, Vol 10, Iss 2504, p 2504 (2021)
Volume 10
Issue 10
Lysosomes are important for proper functioning of the retinal pigment epithelial (RPE) cells. RPE cells have a daily burden of phagocytosis of photoreceptor outer segments (POS) and also degrade cellular waste by autophagy. Here, we identified the ro
Publikováno v:
Cells
Cells, Vol 10, Iss 2507, p 2507 (2021)
Cells, Vol 10, Iss 2507, p 2507 (2021)
Sphingolipids, associated enzymes, and the sphingolipid pathway are implicated in complex, multifaceted roles impacting several cell functions, such as cellular homeostasis, apoptosis, cell differentiation, and more through intrinsic and autocrine/pa
Publikováno v:
Cells
Cells, Vol 10, Iss 2198, p 2198 (2021)
Cells, Vol 10, Iss 2198, p 2198 (2021)
Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent. Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate these cofactors along with iron ions into mitochondrial proteins that support e