Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Huck-Hui Ng"'
Autor:
Huck-Hui Ng, Kevin Andrew Uy Gonzales
Publikováno v:
Cell stem cell. 18(5)
Pluripotent genomes are folded in a topological hierarchy that reorganizes during differentiation. The extent to which chromatin architecture is reconfigured during somatic cell reprogramming is poorly understood. Here we integrate fine-resolution ar
Autor:
Thomas Lufkin, Mikael Huss, Yuriy L. Orlov, Jian-Chien Dominic Heng, Petra Kraus, Jianyong Han, Jianming Jiang, Lin Yang, Bo Feng, Huck-Hui Ng, Jia-Hui Ng, Bing Lim
Publikováno v:
Cell Stem Cell. 6:167-174
SummarySomatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) with the introduction of Oct4, Sox2, Klf4, and c-Myc. Among these four factors, Oct4 is critical in inducing pluripotency because no transcription factor can substitut
Autor:
Huck-Hui Ng, Jia-Hui Ng, Cheng-Peow Tan, Yee-Siang Lim, Xinyi Lu, Wei-Quan Tng, Jonathan Göke, Zhong-Zhi Hong, Yun-Shen Chan, Kevin Andrew Uy Gonzales
Publikováno v:
Cell stem cell. 13(6)
SummaryHuman embryonic stem cells (hESCs) are derived from the inner cell mass of the blastocyst. Despite sharing the common property of pluripotency, hESCs are notably distinct from epiblast cells of the preimplantation blastocyst. Here we use a com
Autor:
Thomas Lufkin, Jianming Jiang, Jonathan Göke, Petra Kraus, Cheng-Peow Tan, Hongqing Liang, Zi-Ying Tan, Kevin Andrew Uy Gonzales, Han-Chung Chong, Guo-Rong Yim, Huck-Hui Ng, Jia-Hui Ng, Jia-Chi Yeo, Yee-Siang Lim, Nguan-Soon Tan
Publikováno v:
Cell stem cell. 14(6)
The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum. However, a pluripotent “ground state,” bearing resemblance to preimplantation mouse epiblasts, can be established through dual inhibition (2i) of both prodifferentiatio
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Publikováno v:
Cell stem cell. 4(4)
Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) can be achieved by viral-mediated transduction of defined transcription factors. Moving toward the eventual goal of clinical application, it is necessary to overcome limitations
Autor:
Yuriy L. Orlov, Huck-Hui Ng, Chia-Lin Wei, Vladimir A. Kuznetsov, Joon Lin Chew, Yijun Ruan, Andre Choo, Steve Oh, Xiao Dong Zhao, Atif Shahab, Guillaume Bourque, Xu Han, Kuo Ping Chiu, Jun Liu, Wing-Kin Sung
Publikováno v:
Cell stem cell. 1(3)
SummaryEpigenetic modifications are crucial for proper lineage specification and embryo development. To explore the chromatin modification landscapes in human ES cells, we profiled two histone modifications, H3K4me3 and H3K27me3, by ChIP coupled with
Autor:
Huck-Hui Ng, Jianming Jiang
Publikováno v:
Cell Stem Cell. 3(2):127-128
The TGFβ/activin signaling pathway is important for the maintenance of human embryonic stem cells. In this issue of Cell Stem Cell, Xu et al. (2008) show that this pathway upregulates the expression of a key pluripotency gene NANOG through SMAD2/3.
Publikováno v:
Cell Stem Cell; Apr2009, Vol. 4 Issue 4, p301-312, 12p, 2 Diagrams, 3 Charts
Autor:
Chin Yan Lim, Wai-Leong Tam, Jinqiu Zhang, Haw Siang Ang, Hui Jia, Lipovich, Leonard, Huck-Hui Ng, Chia-Lin Wei, Wing Kin Sung, Robson, Paul, Yang, Henry, Bing Lim
Publikováno v:
Cell Stem Cell; Nov2008, Vol. 3 Issue 5, p543-554, 12p, 7 Graphs