Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Thomas H"'
A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages
Autor:
Anne M. Hahn, Lisa Vogg, Stefanie Brey, Andrea Schneider, Simon Schäfer, Ralph Palmisano, Anna Pavlova, Inga Sandrock, Likai Tan, Alina S. Fichtner, Immo Prinz, Sarina Ravens, Thomas H. Winkler
Publikováno v:
Cell Reports. 42:112253
Autor:
Timothy M. Caradonna, Larance Ronsard, Ashraf S. Yousif, Ian W. Windsor, Rachel Hecht, Thalia Bracamonte-Moreno, Anne A. Roffler, Max J. Maron, Daniel P. Maurer, Jared Feldman, Elisa Marchiori, Ralston M. Barnes, Daniel Rohrer, Nils Lonberg, Thomas H. Oguin, Gregory D. Sempowski, Thomas B. Kepler, Masayuki Kuraoka, Daniel Lingwood, Aaron G. Schmidt
Publikováno v:
Cell reports. 41(6)
Pathogens evade host humoral responses by accumulating mutations in surface antigens. While variable, there are conserved regions that cannot mutate without compromising fitness. Antibodies targeting these conserved epitopes are often broadly protect
Autor:
Thomas H. McConville, Shivang S. Shah, Tania Wong Fok Lung, Alice Prince, Robert K. Ernst, Anne-Catrin Uhlemann, Alexander M. Chong, Danielle Ahn, Medini K. Annavajhala, Victor G. Castano, Gitanjali Bhushan, Casey E. Hofstaedter, Rajesh Kumar Soni
Publikováno v:
Cell reports
SUMMARY Klebsiella pneumoniae ST258 is a human pathogen associated with poor outcomes worldwide. We identify a member of the acyltransferase superfamily 3 (atf3), enriched within the ST258 clade, that provides a major competitive advantage for the pr
Autor:
Niels Behrendt, Daniel H. Madsen, Majken S. Siersbæk, Loretta Grey Cloud, Lars Grøntved, Henrik J. Jürgensen, Shihui Liu, Dorota Ewa Kuczek, Thomas H. Bugge, Roberto Weigert
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3662-3671 (2017)
Madsen, D H, Jürgensen, H J, Siersbæk, M S, Kuczek, D E, Grey Cloud, L, Liu, S, Behrendt, N, Grøntved, L, Weigert, R & Bugge, T H 2017, ' Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake ', Cell Reports, vol. 21, no. 13, pp. 3662-3671 . https://doi.org/10.1016/j.celrep.2017.12.011
Madsen, D H, Jürgensen, H J, Siersbæk, M S, Kuczek, D E, Grey Cloud, L, Liu, S, Behrendt, N, Grøntved, L, Weigert, R & Bugge, T H 2017, ' Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake ', Cell Reports, vol. 21, no. 13, pp. 3662-3671 . https://doi.org/10.1016/j.celrep.2017.12.011
Physiologic turnover of interstitial collagen is mediated by a sequential pathway in which collagen is fragmented by pericellular collagenases, endocytosed by collagen receptors, and routed to lysosomes for degradation by cathepsins. Here, we use int
Autor:
Jones, Ross A., Harrison, Carl, Eaton, Samantha L., Llavero Hurtado, Maica, Graham, Laura C., Alkhammash, Leena, Oladiran, Oladayo A., Gale, Andy, Lamont, Douglas J., Simpson, Hamish, Simmen, Martin W., Soeller, Christian, Wishart, Thomas M., Gillingwater, Thomas H.
Publikováno v:
Cell Reports, Vol 21, Iss 9, Pp 2348-2356 (2017)
Jones, R A, Harrison, C, Eaton, S L, Llavero Hurtado, M, Graham, L C, Alkhammash, L, Oladiran, O A, Gale, A, Lamont, D J, Simpson, H, Simmen, M W, Soeller, C, Wishart, T M & Gillingwater, T H 2017, ' Cellular and molecular anatomy of the human neuromuscular junction ', Cell Reports, vol. 21, no. 9, pp. 2348–2356 . https://doi.org/10.1016/j.celrep.2017.11.008
Jones, R A, Harrison, C, Eaton, S L, Llavero Hurtado, M, Graham, L C, Alkhammash, L, Oladiran, O A, Gale, A, Lamont, D J, Simpson, H, Simmen, M W, Soeller, C, Wishart, T M & Gillingwater, T H 2017, ' Cellular and molecular anatomy of the human neuromuscular junction ', Cell Reports, vol. 21, no. 9, pp. 2348–2356 . https://doi.org/10.1016/j.celrep.2017.11.008
The neuromuscular junction (NMJ) plays a fundamental role in transferring information from lower motor neuron to skeletal muscle to generate movement. It is also an experimentally accessible model synapse routinely studied in animal models to explore
Autor:
Lukas Rohland, Irmgard Sinning, John A. G. Briggs, Thorsten Trimbuch, Klemens Wild, Simon Bärfuss, Fereshteh Zarebidaki, Andreas F.-P. Sonnen, Christian Rosenmund, Matthias P. Mayer, Thomas H. Söllner, Andrea Scheutzow, Jörg Malsam
Publikováno v:
Cell reports
Cell Reports
Cell Reports
Summary The neuronal protein complexin contains multiple domains that exert clamping and facilitatory functions to tune spontaneous and action potential-triggered synaptic release. We address the clamping mechanism and show that the accessory helix o
Autor:
Anna Kádková, Thomas H. Söllner, Marvin Ruiter, Jörg Malsam, Andrea Scheutzow, Jakob B. Sørensen
Publikováno v:
Ruiter, M, Kádková, A, Scheutzow, A, Malsam, J, Söllner, T H & Sørensen, J B 2019, ' An Electrostatic Energy Barrier for SNARE-Dependent Spontaneous and Evoked Synaptic Transmission ', Cell Reports, vol. 26, no. 9, pp. 2340-2352, e1-e5 . https://doi.org/10.1016/j.celrep.2019.01.103
Information transfer across CNS synapses depends on the very low basal vesicle fusion rate and the ability to rapidly upregulate that rate upon Ca2+ influx. We show that local electrostatic repulsion participates in creating an energy barrier, which
Autor:
Paola Bernabò, Daniele Gubert, Alessandro Quattrone, Marta Marchioretto, Gabriella Viero, Graziano Guella, Elena Perenthaler, Massimiliano Clamer, Divya T. Kandala, Luca Minati, Thomas H. Gillingwater, Rodolfo F. Gómez-Biagi, Ewout J N Groen, Laura Pasquardini, Toma Tebaldi, Fabio Lauria
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 1097-1108.e5 (2018)
Clamer, M, Tebaldi, T, Lauria, F, Bernabò, P, Gomez-Biagi, R F, Marchioretto, M, Kandala, D T, Minati, L, Perenthaler, E, Gubert, D, Pasquardini, L, Guella, G, Groen, E, Gillingwater, T, Quattrone, A & Viero, G 2018, ' Active ribosome profiling with RiboLace ', Cell Reports, vol. 25, no. 4 . https://doi.org/10.1016/j.celrep.2018.09.084
Cell reports 25 (2018): 1097–1108.e5. doi:10.1016/j.celrep.2018.09.084
info:cnr-pdr/source/autori:Clamer M, Tebaldi T, Lauria F, Bernabò P, Gómez-Biagi RF, Marchioretto M, Kandala DT, Minati L, Perenthaler E, Gubert D, Pasquardini L, Guella G, Groen EJN, Gillingwater TH, Quattrone A, Viero G/titolo:Active Ribosome Profiling with RiboLace/doi:10.1016%2Fj.celrep.2018.09.084/rivista:Cell reports/anno:2018/pagina_da:1097/pagina_a:1108.e5/intervallo_pagine:1097–1108.e5/volume:25
Clamer, M, Tebaldi, T, Lauria, F, Bernabò, P, Gomez-Biagi, R F, Marchioretto, M, Kandala, D T, Minati, L, Perenthaler, E, Gubert, D, Pasquardini, L, Guella, G, Groen, E, Gillingwater, T, Quattrone, A & Viero, G 2018, ' Active ribosome profiling with RiboLace ', Cell Reports, vol. 25, no. 4 . https://doi.org/10.1016/j.celrep.2018.09.084
Cell reports 25 (2018): 1097–1108.e5. doi:10.1016/j.celrep.2018.09.084
info:cnr-pdr/source/autori:Clamer M, Tebaldi T, Lauria F, Bernabò P, Gómez-Biagi RF, Marchioretto M, Kandala DT, Minati L, Perenthaler E, Gubert D, Pasquardini L, Guella G, Groen EJN, Gillingwater TH, Quattrone A, Viero G/titolo:Active Ribosome Profiling with RiboLace/doi:10.1016%2Fj.celrep.2018.09.084/rivista:Cell reports/anno:2018/pagina_da:1097/pagina_a:1108.e5/intervallo_pagine:1097–1108.e5/volume:25
Summary: Ribosome profiling, or Ribo-seq, is based on large-scale sequencing of RNA fragments protected from nuclease digestion by ribosomes. Thanks to its unique ability to provide positional information about ribosomes flowing along transcripts, th
Autor:
Ross A, Jones, Carl, Harrison, Samantha L, Eaton, Maica, Llavero Hurtado, Laura C, Graham, Leena, Alkhammash, Oladayo A, Oladiran, Andy, Gale, Douglas J, Lamont, Hamish, Simpson, Martin W, Simmen, Christian, Soeller, Thomas M, Wishart, Thomas H, Gillingwater
Publikováno v:
Cell Reports
Summary The neuromuscular junction (NMJ) plays a fundamental role in transferring information from lower motor neuron to skeletal muscle to generate movement. It is also an experimentally accessible model synapse routinely studied in animal models to
Autor:
Douglas J. Lamont, Thomas H. Gillingwater, Michael J. Naldrett, Thomas M. Wishart, Henryk F. Urbanski, Colin Smith, Steven G. Kohama, Laura C. Graham, Paul Skehel, Barry W. McColl
Publikováno v:
Graham, L C, Naldrett, M J, Kohama, S G, Smith, C, Lamont, D J, Mccoll, B W, Gillingwater, T H, Skehel, P, Urbanski, H F & Wishart, T M 2019, ' Regional molecular mapping of primate synapses during normal healthy ageing ', Cell Reports, vol. 27, no. 4, pp. 1018-1026.e4 . https://doi.org/10.1016/j.celrep.2019.03.096
Normal mammalian brain ageing is characterised by the selective loss of discrete populations of dendritic spines and synapses, particularly affecting neuroanatomical regions such as the hippocampus. Although previous investigations have quantified th