Zobrazeno 1 - 10
of 10
pro vyhledávání: '"11"'
Autor:
Yanwen Gong, Kai Kessenbrock, Quy H. Nguyen, Remy Vu, Xing Dai, Adam L. MacLean, Zixuan Cang, Suoqin Jin, Peng Sun, Daniel Haensel, Enrico Gratton, Qing Nie, Rachel Cinco, Morgan Dragan
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3932-3947.e6 (2020)
Cell reports
Cell reports, vol 30, iss 11
Cell reports
Cell reports, vol 30, iss 11
SUMMARY Our knowledge of transcriptional heterogeneities in epithelial stem and progenitor cell compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and drive wound healing. Previous studies have probed basal cell heter
Autor:
Stephan Blüml, Sylvia Knapp, Leonhard X. Heinz, Guanghou Shui, Florian P. Breitwieser, Berend Snijder, Omar Sharif, Irene M. Aspalter, Manuele Rebsamen, Thomas Karonitsch, Keiryn L. Bennett, Marielle S. Köberlin, Markus R. Wenk, Astrid Fauster, Christoph Baumann, Andreas Pichlmair, Riem Gawish, Jacques Colinge, André C. Müller, Giulio Superti-Furga, Manuela Bruckner, Richard Kumaran Kandasamy
Publikováno v:
Cell Reports
CELL REPORTS
Cell Reports, Elsevier Inc, 2015, 11 (12), pp.1919-1928. ⟨10.1016/j.celrep.2015.05.006⟩
Cell reports
Cell Reports, Vol 11, Iss 12, Pp 1919-1928 (2015)
CELL REPORTS
Cell Reports, Elsevier Inc, 2015, 11 (12), pp.1919-1928. ⟨10.1016/j.celrep.2015.05.006⟩
Cell reports
Cell Reports, Vol 11, Iss 12, Pp 1919-1928 (2015)
Summary Lipid metabolism and receptor-mediated signaling are highly intertwined processes that cooperate to fulfill cellular functions and safeguard cellular homeostasis. Activation of Toll-like receptors (TLRs) leads to a complex cellular response,
Autor:
Aamir Suhail, Prabhakar Mujagond, Preksha Gaur, Vineet Ahuja, C. V. Srikanth, Mukesh Singh, Syed Azmal Ali, Amit Awasthi, Zaigham Abbas Rizvi
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3522-3538.e7 (2019)
Summary: Inflammatory bowel disease (IBD) is a complex autoimmune disorder recently shown to be associated with SUMOylation, a post-translational modification mechanism. Here, we have identified a link between epithelial deSUMOylases and inflammation
Autor:
Jeffrey Hung, Vishva M. Dixit, Debra L. Dugger, Jieqiong Zhang, Joshua D. Webster, Tatiana Goncharov, Youngsu Kwon, Kim Newton, Domagoj Vucic, Merone Roose-Girma
Publikováno v:
Cell Reports, Vol 27, Iss 9, Pp 2679-2689.e3 (2019)
Summary: Cellular inhibitor of apoptosis proteins cIAP1 and cIAP2 ubiquitinate nuclear factor κB (NF-κB)-inducing kinase (NIK) to suppress non-canonical NF-κB signaling and substrates such as receptor interacting protein kinase 1 (RIPK1) to promot
Autor:
Emmanuelle Fantino, Zhijian Xiao, Peter D. Sly, Lin Luo, Maria Paz Marzolo, Samuel J. Tong, Adam A. Wall, Jennifer L. Stow, Yu Hung, Abdullah A. Tarique
Publikováno v:
Cell Reports, Vol 24, Iss 11, Pp 3033-3044 (2018)
BASE-Bielefeld Academic Search Engine
BASE-Bielefeld Academic Search Engine
Summary: The multi-ligand endocytic receptor, low-density lipoprotein-receptor-related protein 1 (LRP1), has anti-inflammatory roles in disease. Here, we reveal that pathogen-activated Toll-like receptors (TLRs) activate LRP1 in human and mouse prima
Autor:
Qin Wei, Diana L. Bonilla, Elmoataz Abdel Fattah, Abhisek Bhattacharya, Qian Xiang, N. Tony Eissa, Jin Na Shin
Publikováno v:
Cell Reports, Vol 12, Iss 11, Pp 1731-1739 (2015)
SummaryAutophagy, an intracellular degradation and energy recycling mechanism, is emerging as an important regulator of immune responses. However, the role of autophagy in regulating neutrophil functions is not known. We investigated neutrophil biolo
Autor:
Anika Stracke, Herbert Strobl, Armin Zebisch, Bernett Lee, Olivia Geiger, Richard A. Flavell, Anton Stift, Gunter Meister, Michaela Beitzinger, Christina Passegger, Clarice X. Lim, Michael Poidinger, Adam Williams, Johann Romberger, Christoph Högenauer, Jorge Henao-Mejia, Heribert Stoiber
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3793-3805.e5 (2020)
Summary: DC-SIGN+ monocyte-derived dendritic cells (mo-DCs) play important roles in bacterial infections and inflammatory diseases, but the factors regulating their differentiation and proinflammatory status remain poorly defined. Here, we identify a
A Decoy Peptide that Disrupts TIRAP Recruitment to TLRs Is Protective in a Murine Model of Influenza
Autor:
Henryk Szmacinski, Kari Ann Shirey, Wenji Piao, Joseph R. Lakowicz, Lisa W. Ru, W.Y.C. Lai, Stefanie N. Vogel, Greg A. Snyder, Vladimir Y. Toshchakov, Eric J. Sundberg
Publikováno v:
Cell Reports, Vol 11, Iss 12, Pp 1941-1952 (2015)
SummaryToll-like receptors (TLRs) activate distinct, yet overlapping sets of signaling molecules, leading to inflammatory responses to pathogens. Toll/interleukin-1 receptor (TIR) domains, present in all TLRs and TLR adapters, mediate protein interac
Autor:
Yuka Namiki, Taishi Kimura, Ryan C. Kunz, Gökhan S. Hotamisligil, Cai Zhang, Takahisa Nakamura, Steven P. Gygi, Celvie L. Yuan, Brenna Baccaro
Publikováno v:
Cell Reports, Vol 11, Iss 2, Pp 295-307 (2015)
SummaryAberrant stress and inflammatory responses are key factors in the pathogenesis of obesity and metabolic dysfunction, and the double-stranded RNA-dependent kinase (PKR) has been proposed to play an important role in integrating these pathways.
Autor:
Marc Veldhoen, Olivier Fesneau, Cristina Ferreira, Silvia Innocentin, Verena Brucklacher-Waldert, Marisa Stebegg, Julien C. Marie
Publikováno v:
Cell Reports
Cell Reports, Vol 19, Iss 11, Pp 2357-2370 (2017)
Cell Reports, Vol 19, Iss 11, Pp 2357-2370 (2017)
Summary T helper-17 (Th17) cells are associated with inflammatory disorders and cancer. We report that environmental conditions resulting in cellular stress, such as low oxygen, glucose, and isotonic stress, particularly enhance the generation of Th1