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pro vyhledávání: ''
Autor:
Nicholas De Veaux, Victor Garcia-Paredes, Mickaël M. Ménager, Xavier Lahaye, Lynn M. Amon, Jarrod S. Johnson, Alexander W. Rives, Marine Luka, Dan R. Littman, Nicolas Manel, Richard Bonneau, Brieuc P. Perot, Alan Aderem, Sasha Y. Lucas, Aaron Watters, Ghaith Abdessalem
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 914-931.e9 (2020)
Cell Reports
Cell Reports, Elsevier Inc, 2020, 30 (3), pp.914-931.e9. ⟨10.1016/j.celrep.2019.12.054⟩
Cell reports
Cell Reports
Cell Reports, Elsevier Inc, 2020, 30 (3), pp.914-931.e9. ⟨10.1016/j.celrep.2019.12.054⟩
Cell reports
SUMMARY Transcriptional programming of the innate immune response is pivotal for host protection. However, the transcriptional mechanisms that link pathogen sensing with innate activation remain poorly under-stood. During HIV-1 infection, human dendr
Autor:
Xuefei Li, Yingping Xu, Zhili Rong, Zhilei Bian, Yongfei Hu, Yu Peng, Yuzhe Sun, Lihua Sun, Bing Liu, Jun Zhang
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109524-(2021)
Summary The immune system of skin develops in stages in mice. However, the developmental dynamics of immune cells in human skin remains elusive. Here, we perform transcriptome profiling of CD45+ hematopoietic cells in human fetal skin at an estimated
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1756-1771 (2018)
Summary: The pluripotent state of embryonic stem cells (ESCs) is defined by its transcriptome and epigenome. The chromatin reader Brd4 determines ESC identity. Although Brd4 regulation in gene transcription has been well described, its contribution t
Autor:
Hitoshi Hiura, Philippe Bouvet, Ryo Funayama, Keiko Nakayama, Tomokatsu Ikawa, Mitsuyo Matsumoto, Tomohiko Tamura, Tapas K. Kundu, Daisuke Kurotaki, Kazuhiko Igarashi, Roger Sciammas, Amrutha Swaminathan, Kyoko Ochiai, Hiroki Shima, Mari Yamaoka, Jun Nakabayashi, Takahiro Arima
Publikováno v:
Cell reports. 33(12)
Summary The chromatin protein positive coactivator 4 (PC4) has multiple functions, including chromatin compaction. However, its role in immune cells is largely unknown. We show that PC4 orchestrates chromatin structure and gene expression in mature B
Autor:
Elisabeth A. Haas, Jayaraj Rajagopal, Brankica Paunovic, Sara O. Vargas, Alan Fine, Molly A. Riehs, Wellington V. Cardoso, Robin L. Haynes, Xingbin Ai, Juliana Barrios, Kimberly Gilmore, Adam L. Haber, Ying Yang, Daniel T. Montoro, Hongmei Mou, Manjunatha Shivaraju
Publikováno v:
Cell reports
Cell Reports, Vol 35, Iss 3, Pp 109011-(2021)
Cell Reports, Vol 35, Iss 3, Pp 109011-(2021)
SUMMARY Pulmonary neuroendocrine cells (PNECs) have crucial roles in airway physiology and immunity by producing bioactive amines and neuropeptides (NPs). A variety of human diseases exhibit PNEC hyperplasia. Given accumulated evidence that PNECs rep
Publikováno v:
Cell Reports, Vol 31, Iss 4, Pp-(2020)
Summary: Bone morphogenic protein (BMP)/transforming growth factor β (TGF-β) signaling determines mesenchymal-stromal-cell (MSC) osteolineage commitment and tissue identity. However, molecular integration of developmental signaling with MSC-intrins
Autor:
Erik M. Shapiro, Sae Jang, Rodrigo M. Florentino, Ira J. Fox, Tomoji Mashimo, Kan Handa, Andrew W. Duncan, Fangchao Yuan, Wendell Sun, Jorge Guzman-Lepe, Alexandra Collin de l'Hortet, Nils Haep, Kimimasa Tobita, Alejandro Soto-Gutierrez, Evan R. Delgado, Hiroshi Yagi, Nicolas A. Fraunhoffer, Kazuki Takeishi, Kentaro Matsubara, Yang Wang, Kazutoyo Morita, Jonathan Franks, Ken Fukumitsu
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp-(2020)
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Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment of liver disease. Assembly and function in vivo of a bioengineered human liver derived from induced pluripotent stem cells (iPSCs) has not been p
Autor:
Babal K. Jha, Francis Enane, Caroline Schuerger, Xiaorong Gu, Rita Tohme, Yogen Saunthararajah, Bartlomiej P Przychodzen, Eric Zuberi, Yvonne Parker, Brian I. Rini, Daniel J. Lindner, Tomas Radivoyevitch
Publikováno v:
Cell reports
Cell Reports, Vol 36, Iss 12, Pp 109747-(2021)
Cell Reports, Vol 36, Iss 12, Pp 109747-(2021)
SUMMARY PBRM1, a subunit of the PBAF coactivator complex that transcription factors use to activate target genes, is genetically inactivated in almost all clear cell renal cell cancers (RCCs). Using unbiased proteomic analyses, we find that PAX8, a m
Autor:
Adam D. Durbin, Brian C. Beleyea, David M. Langenau, Corinne M. Linardic, Petur Nielsen, Sophia M. Reeder, Myron S. Ignatius, Sivasish Sindiri, Karin M. McCarthy, Aleksey Molodtsov, Prethish Sreenivas, Javed Khan, Riadh Lobbardi, Zainab Motala, Eleanor Y. Chen, Alexander Jin, Madeline N. Hayes, Charles Keller, Deepak Bhere, David Malkin, Matthew S. Alexander, Khalid Shah
Publikováno v:
Cell reports
Cell Reports, Vol 19, Iss 11, Pp 2304-2318 (2017)
Cell Reports, Vol 19, Iss 11, Pp 2304-2318 (2017)
Summary Tumor-propagating cells (TPCs) share self-renewal properties with normal stem cells and drive continued tumor growth. However, mechanisms regulating TPC self-renewal are largely unknown, especially in embryonal rhabdomyosarcoma (ERMS)—a com
Autor:
Irwin D. Bernstein, Wenqing Cai, George Q. Daley, Erik Serrao, Brandon Hadland, Samantha J. Ross, Yi Fen Lu, Alan Engelman, Patricia Sousa, Julie M. Sahalie, Patrick Cahan
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3178-3192 (2016)
Hematopoietic stem cell (HSC) transplantation is curative for malignant and genetic blood disorders, but is limited by donor availability and immune-mismatch. Deriving HSCs from patient-matched embryonic/induced-pluripotent stem cells (ESCs/iPSCs) co