Zobrazeno 1 - 1
of 1
pro vyhledávání: '"Bin Xiao"'
Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
Autor:
Richard F. Lamb, Dongmei Zuo, William J. Muller, Bin Xiao, Robert D. Cardiff, Nahum Sonenberg, Alison Hirukawa
Publikováno v:
Cell Rep
Cell Reports, Vol 31, Iss 4, Pp-(2020)
Cell Reports, Vol 31, Iss 4, Pp-(2020)
Summary: Mechanistic target of rapamycin complex 1 (mTORC1) is a master modulator of cellular growth, and its aberrant regulation is recurrently documented within breast cancer. While the small GTPase Rheb1 is the canonical activator of mTORC1, Rheb1