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Publikováno v:
Cell Proliferation
Objective Human chorionic membrane extracts (CMEs) from placenta are known to be a natural biomaterial for bone regeneration, with their excellent osteogenic efficacy on osteoblasts. However, little is known about the regulatory mechanism involved. M
Autor:
Sanghyuk Lee, Eunji Cheong, Dong-Youn Hwang, C. Justin Lee, Kun-Gu Lee, Hye Bin Noh, H.S. Kim, Bomi Chang
Publikováno v:
Cell Proliferation
Objectives The derivation of neural crest stem cells (NCSCs) from human pluripotent stem cells (hPSCs) has been commonly induced by WNT activation in combination with dual‐SMAD inhibition. In this study, by fine‐tuning BMP signalling in the conve
Autor:
Xuemei Liu, Meiling Wu, Bei Li, Hao Guo, Kun Xuan, Zihan Li, Xiaoxue Yang, Yan Jin, Xiaoyao Huang, Xiaohe Guo
Publikováno v:
Cell Proliferation
Objectives Pulp regeneration brings big challenges for clinicians, and vascularization is considered as its determining factor. We previously accomplished pulp regeneration with autologous stem cells from deciduous teeth (SHED) aggregates implantatio
Autor:
Zheng Li, Matthew T. V. Chan, Xingye Li, Shugang Li, Sunny H. Wong, Ziheng Huang, Cheng Huang, Lin Zhang, Jianxiong Shen, William K.K. Wu
Publikováno v:
Cell Proliferation
Objectives Guillain‐Barré syndrome (GBS) results from autoimmune attack on the peripheral nerves, causing sensory, motor and autonomic abnormalities. Emerging evidence suggests that there might be an association between COVID‐19 and GBS. Neverth
Publikováno v:
Cell Proliferation
Objective As an inhibitor of the AhR signalling pathway, StemRegenin 1 (SR1) not only promotes the expansion of CD34+ cells but also increases CD34− cell numbers. These CD34− cells influenced the ex vivo expansion of CD34+ cells. In this work, th
Autor:
Tao Cheng, Jun Shen, Zicen Feng, Yaoyao Zhu, Shuzhen Lyu, Cuicui Lyu, Zack Z. Wang, Dixie L. Hoyle, Shuo Zhang
Publikováno v:
Cell Proliferation
Objectives Vitronectin (VTN) has been widely used for the maintenance and expansion of human pluripotent stem cells (hPSCs) as feeder‐free conditions. However, the effect of VTN on hPSC differentiation remains unclear. Here, we investigated the rol
Publikováno v:
Cell Proliferation
Osteoblasts and osteoclasts participate in the process of bone remodelling to meet the needs of normal growth and development or repair pathological damage. Endoplasmic reticulum stress (ER stress) can break the intracellular homeostasis of osteoclas
Publikováno v:
Cell Proliferation
Objectives Stromal cell‐derived factor‐1 (SDF‐1) actively directs endogenous cell homing. Exendin‐4 (EX‐4) promotes stem cell osteogenic differentiation. Studies revealed that EX‐4 strengthened SDF‐1‐mediated stem cell migration. Howe
Publikováno v:
Cell Proliferation
Objectives Silicate bioactive glass (BG) has been widely demonstrated to stimulate both of the hard and soft tissue regeneration, in which ion products released from BG play important roles. However, the mechanism by which ion products act on cells o
Publikováno v:
Cell Proliferation
Objectives It is of profound significance for clinical bone regeneration to clarify the specific molecular mechanism from which we found that osteogenic differentiation of adipose‐derived stem cells (ADSCs) will be probably promoted by exosomes. Ma