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Autor:
Ling-Hao Zhao, Guojun Hou, Jie Wang, Sheng-xian Yuan, Da-Peng Sun, Jian Yu, Wen-Bin Ding, Yuan Yang, Dong-yang Ding, Lei Liu, Wei-ping Zhou, Fu Yang, Wen Li, Xiao-jie Gan, Junyao Jiang
Publikováno v:
Cell deathdisease. 13(5)
Background: DNA methylation plays a pivotal role in the development and progression of tumors, but studies focused on the dynamic changes of DNA methylation in the development of hepatocellular carcinoma (HCC) are rare. This manuscript is aimed to co
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Lysosomes are organelles involved in cell metabolism, waste degradation, and cellular material circulation. They play a key role in the maintenance of cellular physiological homeostasis. Compared with the lysosomal content of other organs, that of th
Autor:
Lang Fang, Bowen Li, Penghui Xu, Sen Wang, Zekuan Xu, Zetian Chen, Lu Zhang, Li Xie, Jiacheng Cao, Xing Zhang, Jing Yang
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 10, Pp 1-16 (2021)
Cell Death and Disease, Vol 12, Iss 10, Pp 1-16 (2021)
Gastric cancer remains the third leading cause of cancer-related mortality worldwide. Emerging evidence has shown that circular RNAs (circRNAs) play a critical regulatory role in the occurrence and development of various cancers through sponging miRN
Autor:
Yan-Li Zhang, Qing Li, Hengchao Li, Zhigang Zhang, Bo Ni, Xiaoxin Zhang, Rong-Kun Li, De-Jun Liu, Li-Peng Hu, Shu-Heng Jiang, Lili Zhu, Xu Wang
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 12, Pp 1-14 (2021)
Cell Death and Disease, Vol 12, Iss 12, Pp 1-14 (2021)
Hypoxic microenvironment is common in solid tumors, particularly in pancreatic ductal adenocarcinoma (PDAC). The Warburg effect is known to facilitate cancer aggressiveness and has long been linked to hypoxia, yet the underlying mechanism remains lar
Autor:
Rafael G. Costa, David V. C. Brito, Carina Henriques, Clévio Nóbrega, Benedita Ferreira, Carlos A. Matos, Rui Jorge Nobre, Adriana Marcelo, João Alves-Cruzeiro, Ricardo Afonso-Reis, Luís Pereira de Almeida, Ana Rosa, Inês T. Afonso
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 12, Pp 1-13 (2021)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cell Death and Disease, Vol 12, Iss 12, Pp 1-13 (2021)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Spinocerebellar ataxia type 2 (SCA2) is an incurable and genetic neurodegenerative disorder. The disease is characterized by progressive degeneration of several brain regions, resulting in severe motor and non-motor clinical manifestations. The mutat
Autor:
Heike Bantel, Ulrich Lehmann, Katharina John, Frank Essmann, Klaus Schulze-Osthoff, F Wandrer, Stephanie Busche, Florian W. R. Vondran, Heiner Wedemeyer
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 8, Pp 1-11 (2021)
Cell Death and Disease, Vol 12, Iss 8, Pp 1-11 (2021)
Hepatocellular carcinoma (HCC) represents a global health challenge with limited therapeutic options. Anti-angiogenic immune checkpoint inhibitor-based combination therapy has been introduced for progressed HCC, but improves survival only in a subset
Autor:
Licheng Zhang, Liu Zhongyang, Peifu Tang, Li Miao, Li Ming, Junhao Deng, Zhirui Li, Yuan Zhang, Song Wang, Fanqi Meng
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 12, Pp 1-15 (2021)
Cell Death and Disease, Vol 12, Iss 12, Pp 1-15 (2021)
Mesenchymal stem cell (MSC) is an absorbing candidate for cell therapy in treating spinal cord injury (SCI) due to its great potential for multiple cell differentiation, mighty paracrine secretion as well as vigorous immunomodulatory effect, of which
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-10 (2021)
Enhanced DNA damage repair capacity attenuates cell killing of DNA-damaging chemotherapeutic agents. In silico analysis showed that epithelial membrane protein 3 (EMP3) is associated with favorable survival, and negatively regulates cell cycle S-phas
Autor:
Sergio Ruggiero, Katia Aquilano, Antonio Picardi, Simone Carotti, Maria Zingariello, Fiorella Piemonte, Sergio Morini, Daniele Lettieri-Barbato, Maria Francesconi, Giuseppe Perrone, Francesca Arciprete, Francesca Zalfa, Umberto Vespasiani-Gentilucci, Raffaele Antonelli-Incalzi, Jessica D’Amico, Francesco Valentini, Antonio De Vincentis, Andrea Baiocchini, Marco Rosina
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 12, Pp 1-10 (2021)
Cell Death and Disease, Vol 12, Iss 12, Pp 1-10 (2021)
Recent studies demonstrated reduced blood lysosomal acid lipase (LAL) activity in patients with nonalcoholic fatty liver disease (NAFLD). We aimed to verify hepatic LAL protein content and activity in in vitro and in vivo models of fat overload and i
Autor:
Pengfei Li, Hang Zhou, Yan Peng, Caixia Xu, Xudong Wang, Dongsheng Huang, Bo Gao, Xianjian Qiu, Yanbo Chen, Taiqiu Chen, Wenjie Gao, Jincheng Qiu, Zhihuai Deng, Peiqiang Su, Anjing Liang, Tongzhou Liang, Yuanxin Zhu
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 10, Pp 1-13 (2021)
Cell Death and Disease, Vol 12, Iss 10, Pp 1-13 (2021)
Osteoarthritis (OA) is characterized by cartilage destruction, chronic inflammation, and local pain. Evidence showed that retinoic acid receptor-related orphan receptor-α (RORα) is crucial in cartilage development and OA pathogenesis. Here, we inve