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Autor:
Furong Xie, Qinggang Dai, Ningning Niu, Siru Zhou, Weiguo Zou, Xuhui Ma, Jun Wang, Lingyong Jiang, Zhan Xu
Publikováno v:
Cell Death and Differentiation
The mammalian target of rapamycin (mTOR)/regulatory-associated protein of mTOR (Raptor) pathway transmits and integrates different signals including growth factors, nutrients, and energy metabolism. Nearly all these signals have been found to play ro
Autor:
Darren W. Williams, Amrita Mukherjee
Publikováno v:
Cell Death and Differentiation
Nervous systems are arguably the most fascinating and complex structures in the known universe. How they are built, changed by experience and then degenerate are some of the biggest questions in biology. Regressive phenomena, such as neuron pruning a
Autor:
Lynn A. Megeney, Ryan A. V. Bell
Publikováno v:
Cell Death and Differentiation
The phenotypic and biochemical similarities between caspase-mediated apoptosis and cellular differentiation are striking. They include such diverse phenomenon as mitochondrial membrane perturbations, cytoskeletal rearrangements and DNA fragmentation.
Autor:
Anna C Gormley, Maria I. Morasso, Shreya Bhattacharya, Stuart H. Yuspa, Meghan D. Kellett, Elisabetta Palazzo, Christophe Cataisson, Hong-Wei Sun, Paul W Bible
Publikováno v:
Cell Death and Differentiation
Epidermal homeostasis relies on a well-defined transcriptional control of keratinocyte proliferation and differentiation, which is critical to prevent skin diseases such as atopic dermatitis, psoriasis or cancer. We have recently shown that the homeo
Autor:
Nicole Malkusch, Jeanette Knoll, Sooyeon Lee, Ulf H. Lerner, Jan Tuckermann, Mario M. Zaiss, Mona Neven, Susanne Ostermay, Alexander Rauch, Julia Luther, Philippe Bertolino, Martina Rauner, Chang X. Zhang, Peng Liu, Jean-Pierre David, Rainer Wittig
Publikováno v:
Cell Death and Differentiation
Cell death and differentiation, 24:672-682
Cell death and differentiation, 24:672-682
During osteoporosis bone formation by osteoblasts is reduced and/or bone resorption by osteoclasts is enhanced. Currently, only a few factors have been identified in the regulation of bone integrity by osteoblast-derived osteocytes. In this study, we
Autor:
Wyne P. Lee, Donald S. Kirkpatrick, Matthias Kist, Joshua D. Webster, Domagoj Vucic, Kim Newton, Eugene Varfolomeev, Xiumin Wu, M. Cristina de Almagro, Kebing Yu, Jeremy Murray, Stefanie Duttler, Tatiana Goncharov, Anita Izrael-Tomasevic
Publikováno v:
Cell Death and Differentiation
Proper regulation of cell death signaling is crucial for the maintenance of homeostasis and prevention of disease. A caspase-independent regulated form of cell death called necroptosis is rapidly emerging as an important mediator of a number of human
Autor:
M Jiang, Yanyan Han, Liangyu Lin, Qing Chen, G Cao, Qian Yang, Yuyao Wang, Yufang Shi, J Cao, Tania Velletri, C Zheng, Peishun Shou, Wei Cao, Fengying Li
Publikováno v:
Cell Death and Differentiation
Multiple sclerosis (MS) is a chronic and debilitating autoimmune disease, characterized by chronic inflammatory demyelination in the nervous tissue and subsequent neurological dysfunction. Spermidine, a natural polyamine, has been shown to affect inf
Autor:
Jianghuai Liu, J. Li, B. Shen, Xiuwen Wu, Toshihiko Yanase, M. Huang, X. Huang, Zhipeng Qu, Chengji J. Zhou, Zeyi Liu, Ying Xu, Zhen Dong, T. Zhang, P. Xie, Y. Dong
Publikováno v:
Cell Death and Differentiation
Granulosa cells (GCs) are tightly associated with fertility and the fate of ovarian follicles. Mitochondria are the central executers of apoptosis. However, the genetic basis underlying mitochondrial modulation in GCs during the ovarian development i
Autor:
Kirsten Smalley, Sangwon Min, Lisa A. Beck, Jonathan E. Bard, A. De Benedetto, J Nyquist, R-A Romano, Takeshi Yoshida, Akinsola Oyelakin, Jason M. Rizzo, Satrajit Sinha, Emma Guttman-Yassky, Wei Luo
Publikováno v:
Cell Death and Differentiation
Atopic dermatitis (AD) is the most common inflammatory skin disease with no well-delineated cause or effective cure. Here we show that the p53 family member p63, specifically the ΔNp63, isoform has a key role in driving keratinocyte activation in AD
Autor:
Tomás Sobrino, Juan J Duarte, María E. Ramos-Araque, José Castillo, José C. Gómez-Sánchez, Cristina Rodríguez, Juan P. Bolaños, Veronica Bobo-Jimenez, Angeles Almeida, Jesús Agulla
Publikováno v:
Cell Death and Differentiation
Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC. Repositorio Institucional del CSIC
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Intracerebral hemorrhage (ICH) is a devastating subtype of stroke that lacks effective therapy and reliable prognosis. Neovascularization following ICH is an essential compensatory response that mediates brain repair and modulates the clinical outcom