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Autor:
Marcel Werner, Anna Dyas, Iwan Parfentev, Geske E. Schmidt, Iga K. Mieczkowska, Lukas C. Müller-Kirschbaum, Claudia Müller, Stefan Kalkhof, Oliver Reinhardt, Henning Urlaub, Frauke Alves, Julia Gallwas, Evangelos Prokakis, Florian Wegwitz
Publikováno v:
Cell Death and Disease
Cell Death Dis. 13:762 (2022)
Cell Death Dis. 13:762 (2022)
Basal-like breast cancer (BLBC) is a highly aggressive breast cancer subtype frequently associated with poor prognosis. Due to the scarcity of targeted treatment options, conventional cytotoxic chemotherapies frequently remain the standard of care. U
Autor:
Dandan Li, Mengjie Xu, Zidi Wang, Pan Huang, Congcong Huang, Zhen Chen, Gaijuan Tang, Xingji Zhu, Mengyu Cai, Shanshan Qin
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-10 (2022)
Cell Death & Disease
Cell Death & Disease
Deregulated lncRNAs play critical roles in tumorigenesis and tumor progression. NR2F1-AS1 is an antisense lncRNA of NR2F1. However, the biological function of NR2F1-AS1 in gastric cancer (GC) remains largely unclear. In this study, we revealed that N
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-9 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-9 (2022)
Jumonji domain containing protein 2C (JMJD2C) could epigenetically regulate cancer cells. We specifically explored the downstream mechanism of JMJD2C in non-small cell lung cancer (NSCLC) from the long non-coding RNA metastasis associated with lung a
Autor:
Fu, Dechen, Pfannenstiel, Luke, Demelash, Abeba, Phoon, Yee Peng, Mayell, Cameron, Cabrera, Claudia, Liu, Caini, Zhao, Junjie, Dermawan, Josephine, Patil, Deepa, DeVecchio, Jennifer, Kalady, Matthew, Souers, Andrew J., Phillips, Darren C., Li, Xiaoxia, Gastman, Brian
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-11 (2022)
Cell Death & Disease
Cell Death & Disease
Colorectal cancer (CRC) is one of the most common and deadliest forms of cancer. Myeloid Cell Leukemia 1 (MCL1), a pro-survival member of the Bcl-2 protein family is associated with chemo-resistance in CRC. The ability of MCL1 to inhibit apoptosis by
Autor:
Huaiming Sang, Weifeng Zhang, Lei Peng, Shuchun Wei, Xudong Zhu, Keting Huang, Jiajia Yang, Meihong Chen, Yini Dang, Guoxin Zhang
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-11 (2022)
Cell Death & Disease
Cell Death & Disease
Circular RNAs (circRNAs) play a vital role in the occurrence and development of tumors, including gastric cancer (GC). However, there are still many circRNAs related to GC whose functions and molecular mechanisms remain undetermined. Herein, we disco
Autor:
Greta Del Mistro, Shamala Riemann, Sebastian Schindler, Stefan Beissert, Roland E. Kontermann, Aurelien Ginolhac, Rashi Halder, Luana Presta, Lasse Sinkkonen, Thomas Sauter, Dagmar Kulms
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-15 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-15 (2022)
Despite remarkable advances in therapeutic interventions, malignant melanoma (MM) remains a life-threating disease. Following high initial response rates to targeted kinase-inhibition metastases quickly acquire resistance and present with enhanced tu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
Cell Death & Disease
Cell Death & Disease
Triple-negative breast cancer (TNBC) has been shown with high mitochondrial oxidative phosphorylation and production of reactive oxygen species (ROS). MnSOD (SOD2) is a mitochondrial antioxidant defense that has been implicated in inhibition of human
Autor:
Yongsheng Huang, Sijia Liu, Mengjie Shan, Sophie C. Hagenaars, Wilma E. Mesker, Danielle Cohen, Lin Wang, Zhi Zheng, Peter Devilee, Rob A. E. M. Tollenaar, Zhangfu Li, Yongmei Song, Long Zhang, Dan Li, Peter ten Dijke
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-12 (2022)
Cell Death and Disease, 13(1). SPRINGERNATURE
Cell Death and Disease, Vol 13, Iss 1, Pp 1-12 (2022)
Cell Death and Disease, 13(1). SPRINGERNATURE
Transforming growth factor-β (TGF-β) acts as a pro-metastatic factor in advanced breast cancer. RNF12, an E3 ubiquitin ligase, stimulates TGF-β signaling by binding to the inhibitory SMAD7 and inducing its proteasomal degradation. How RNF12 activi
Autor:
Amrita Salvi, Alexandria N. Young, Andrew C. Huntsman, Melissa R. Pergande, Melissa A. Korkmaz, Rathnayake A. Rathnayake, Brittney K. Mize, A. Douglas Kinghorn, Xiaoli Zhang, Kiira Ratia, Markus Schirle, Jason R. Thomas, Scott M. Brittain, Claude Shelton, Leslie N. Aldrich, Stephanie M. Cologna, James R. Fuchs, Joanna E. Burdette
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
PHY34 is a synthetic small molecule, inspired by a compound naturally occurring in tropical plants of the Phyllanthus genus. PHY34 was developed to have potent in vitro and in vivo anticancer activity against high grade serous ovarian cancer (HGSOC)
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 13, Iss 1, Pp 1-11 (2022)
Cell Death and Disease, Vol 13, Iss 1, Pp 1-11 (2022)
iCasp9 suicide gene has been widely used as a promising killing strategy in various cell therapies. However, different cells show significant heterogeneity in response to apoptosis inducer, posing challenges in clinical applications of killing strate