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Autor:
Aoran Luo, Xiaoxiao Lan, Qiongzi Qiu, Qing Zhou, Jia Li, Mengting Wu, Pengyuan Liu, Honghe Zhang, Bingjian Lu, Yan Lu, Weiguo Lu
Publikováno v:
Cell Death & Disease. 13
Long non-coding RNAs (lncRNAs) play key roles in cancer development and progression. However, the biological function and clinical significance of most lncRNAs in cervical cancer remain elusive. In this study, we explore the function and mechanism of
Autor:
Chaoqing Huang, Yuan Wang
Publikováno v:
Cell Death & Disease. 13
Osteoporosis (OP) tends to occur in postmenopausal women, making them prone to fractures. N6-methyladenosine (m6A) methylation plays a crucial role in OP. Herein, we aimed to explore the effects of METTL14 on osteogenesis and the underlying mechanism
Publikováno v:
Cell Death & Disease. 13
Poly (ADP-ribose) polymerase (PARP) inhibitors are efficacious in treating platinum-sensitive ovarian cancer (OC), but demonstrate limited efficiency in patients with platinum-resistant OC. Thus, further investigations into combined strategies that e
Autor:
Marcel Werner, Anna Dyas, Iwan Parfentev, Geske E. Schmidt, Iga K. Mieczkowska, Lukas C. Müller-Kirschbaum, Claudia Müller, Stefan Kalkhof, Oliver Reinhardt, Henning Urlaub, Frauke Alves, Julia Gallwas, Evangelos Prokakis, Florian Wegwitz
Publikováno v:
Cell Death and Disease
Cell Death Dis. 13:762 (2022)
Cell Death Dis. 13:762 (2022)
Basal-like breast cancer (BLBC) is a highly aggressive breast cancer subtype frequently associated with poor prognosis. Due to the scarcity of targeted treatment options, conventional cytotoxic chemotherapies frequently remain the standard of care. U
Autor:
Trinh-Le-Vi Kieu, Léa Pierre, Valentin Derangère, Sabrina Perrey, Caroline Truntzer, Antoine Jalil, Sébastien Causse, Emma Groetz, Adélie Dumont, Laura Guyard, Laurent Arnould, Jean-Paul Pais de Barros, Lionel Apetoh, Cédric Rébé, Emeric Limagne, Tony Jourdan, Laurent Demizieux, David Masson, Charles Thomas, François Ghiringhelli, Mickaël Rialland
Publikováno v:
Cell Death & Disease. 13
Metastatic breast cancer cannot be cured, and alteration of fatty acid metabolism contributes to tumor progression and metastasis. Here, we were interested in the elongation of very long-chain fatty acids protein 5 (Elovl5) in breast cancer. We obser
Autor:
Xiaoyang Liu, Sandhya Chipurupalli, Peijia Jiang, Mahtab Tavasoli, Byong Hoon Yoo, Michael McPhee, Sina Mazinani, Giulio Francia, Robert S. Kerbel, Kirill V. Rosen
Publikováno v:
Cell Death & Disease. 13
A significant proportion of breast cancers are driven by ErbB2/Her2 oncoprotein that they overexpress. These malignancies are typically treated with various ErbB2-targeted drugs, but many such cancers develop resistance to these agents and become inc
Publikováno v:
Cell Death & Disease. 13
As the predominant stroma cells of tumor microenvironment (TME), cancer associated fibroblasts (CAFs) are robust tumor player of different malignancies. However, less is known about the regulatory mechanism of CAFs on promoting progression of ovarian
Autor:
Jing Ji, Jing Shen, Yuxin Xu, Mengru Xie, Qilan Qian, Teng Qiu, Wen Shi, Dexu Ren, Jinming Ma, Wei Liu, Bin Liu
Publikováno v:
Cell Death & Disease. 13
SAD1/UNC84 domain protein-2 (SUN2) plays a tumor suppressor role in various types of cancer by inhibiting cancer cell proliferation, migration and promoting apoptosis. However, the post-translational regulation of SUN2 and the cellular mechanism resp
Autor:
Qing Liu, Enyang Zhao, Bo Geng, Shan Gao, Hongyang Yu, Xinyang He, Xuedong Li, Guanglu Dong, Bosen You
Publikováno v:
Cell Death & Disease. 13
Previous studies have investigated whether tumor-associated macrophages (TAMs) play tumorigenic and immunosuppressive roles to encourage cancer development, but the role of TAMs in regulating vasculogenic mimicry (VM) in clear-cell renal cell carcino
Publikováno v:
Cell Death & Disease. 13
Vascular calcification (VC) is a significant complication of chronic kidney disease (CKD) and cellular apoptosis is one of the intricate mechanisms of VC. Bone marrow mesenchymal stem cell-derived exosome (BMSC-Exo) alleviates VC, but the mechanism r