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Publikováno v:
Cell Cycle. 17:739-748
RCC1 associates to chromatin dynamically within mitosis and catalyzes Ran-GTP production. Exogenous RCC1 disrupts kinetochore structure in Xenopus egg extracts (XEEs), but the molecular basis of this disruption remains unknown. We have investigated t
Autor:
Zhi-Bin Niu, Jiong Ren, Tao Zhang, Xu-Dong Li, Mei-Jiao Gao, Bo-Yang Zhang, Fengchao Wang, Yongping Su, Xinze Ran, Cai-zhi Tang
Publikováno v:
Cell Cycle. 17:780-791
Although the regulatory network of G2/M phase transition has been intensively studied in mammalian cell lines, the identification of morphological and molecular markers to identify G2/M phase transition in vivo remains elusive. In this study, we foun
Autor:
Fritz C. Eilber, Yunfeng Li, Robert M. Hoffman, Yukihiko Hiroshima, Ryusei Matsuyama, Itaru Endo, Kentaro Miyake, Takashi Chishima, Tasuku Kiyuna, Takashi Murakami, Kentaro Igarashi, Scott D. Nelson, Tara A. Russell, Arun S. Singh, Masashi Momiyama, Irmina A. Elliott, Zhiying Zhang, Masuyo Miyake, Kei Kawaguchi
Publikováno v:
Cell cycle (Georgetown, Tex.), vol 17, iss 6
Gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit is a rare type of sarcoma. The aim of this study was to determine drug sensitivity for a regionally-recurrent case of GIST using a patient-derived orthotopic xenograft
Autor:
Martin C. Sadowski, Rohan A. Davis, Melanie Lehman, Claire Levrier, Colleen C. Nelson, Brian Gabrielli, Anja Rockstroh, Maria Kavallaris
Publikováno v:
Cell Cycle
We report for the first time the mechanism of action of the natural product thalicthuberine (TH) in prostate and cervical cancer cells. TH induced a strong accumulation of LNCaP cells in mitosis, severe mitotic spindle defects, and asymmetric cell di
Publikováno v:
Cell Cycle
LncRNA in non-homologous end joining (NHEJ) pathway 1 (LINP1) is an lncRNA which promotes therapeutic resistance in triple-negative breast cancer (TNBC). However, the expression and function of LINP1 in cervical cancer is not yet well-understood. In
Autor:
Amriti R. Lulla, Jeffrey J. Pu, Jawad Babar, Nadia Khan, Cyril H. Benes, Lanlan Zhou, Joshua E. Allen, A. Pieter J. van den Heuvel, Ultan McDermott, Mala K. Talekar, Mathew J. Garnett, C. Leah B. Kline, Junior Hall, Wolfgang Oster, David F. Claxton, Varun V. Prabhu, David T. Dicker, Wafik S. El-Deiry, Stephan A. Grupp
Publikováno v:
Cell Cycle. 17:468-478
ONC201, founding member of the imipridone class of small molecules, is currently being evaluated in advancer cancer clinical trials. We explored single agent and combinatorial efficacy of ONC201 in preclinical models of hematological malignancies. ON
Autor:
Zhongxian Zhu, Zechao Wen, Hongxing Li, Yankai Xia, Qiyang Shen, Lei Peng, Chunxia Du, Weibing Tang, Hua Zhang, Yang Su, Hua Xie, Guanglin Chen
Publikováno v:
Cell Cycle. 17:459-467
Recently studies reported that long non-coding RNAs (lncRNAs) may take part in a lot of congenital diseases, meanwhile, Hirschsprung's disease (HSCR) is a major congenital digestive tract malformation. Nevertheless whether lncRNAs participate in the
Autor:
Nicolas J. Tourasse, Armelle Choquet, Dominique Joubert, Delphine Allard, Tom Lesluyes, Hélène Dumay-Odelot, Stéphanie Durrieu-Gaillard, Galina Boldina, Jean-William Dupuy, Pauline Lagarde, Robert G. Roeder, Guillaume Drutel, Stéphan Vagner, Marion Petitet, Frédéric Chibon, Françoise Macari, Martin Teichmann, Thierry Leste-Lasserre, Lydia Lartigue-Faustin, Fabrice Andre
Publikováno v:
Cell Cycle. 17:605-615
RNA polymerase (Pol) III transcribes small untranslated RNAs that are essential for cellular homeostasis and growth. Its activity is regulated by inactivation of tumor suppressor proteins and overexpression of the oncogene c-MYC, but the concerted ac
Autor:
Olga Kovalchuk, Anton Buzdin, Alex Zhavoronkov, Victor Tkachev, Maria Suntsova, Ilya Muchnik, Nicolas Borisov
Publikováno v:
Cell Cycle. 17:486-491
Personalized medicine implies that distinct treatment methods are prescribed to individual patients according several features that may be obtained from, e.g., gene expression profile. The majority of machine learning methods suffer from the deficien
Autor:
Yu Jie Bao, Lu Chen, Chen Yang Yu, Jing-Yuan Fang, Hao Yan Chen, Sheng Li Yang, Jie Hong, Jiayin Tang, Jinxian Chen
Publikováno v:
Cell Cycle. 17:102-109
TEAD4 (TEA domain family member 4) was recently revealed as an oncogenic character in tumorigenesis. However, its role remains unclear in colorectal tumorigenesis. Here, we firstly found that the expression level of TEAD4 was significantly elevated i