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Autor:
Faris Alrumaihi, Mahmoud Moustafa, Esraa A A Badr, Mohamed A. M. Atia, Nahlah Makki Almansour, Alaa H.M. Abdelrahman, Ahmed M. Shawky, Mahmoud A. A. Ibrahim, Gamal A.H. Mekhemer
Publikováno v:
Cell biochemistry and biophysics. 79(2)
Breast cancer resistance protein (ABCG2) is a human ATP-binding cassette (ABC) that plays a paramount role in multidrug resistance (MDR) in cancer therapy. The discovery of ABCG2 inhibitors could assist in designing unprecedented therapeutic strategi
Autor:
Fisayo A. Olotu, Ransford Oduro Kumi, Mahmoud E. S. Soliman, Abdul Rashid Issahaku, Clement Agoni
Publikováno v:
Cell biochemistry and biophysics. 78(3)
The predominance of Alzheimer's disease (AD) among the aged remains a global challenge. As such, the search for alternative and effective therapeutic options continuous unabated. Among the therapeutic targets explored over the years toward impeding t
Autor:
Seyed Shahriar Arab, Leila Karami, Shima Aliebrahimi, Shideh Montasser Kouhsari, Seyed Nasser Ostad
Publikováno v:
Cell Biochemistry and Biophysics
c-Met receptor tyrosine kinase is a proto-oncogene whose aberrant activation is attributed to a lower rate of survival in most cancers. Natural product-derived inhibitors known as "fourth generation inhibitors" constitute more than 60% of anticancer
Autor:
Nan Zhang, Hui Yao, Yulun Huang, Yanyan Li, Jiangang Liu, Xuewen Zhang, Fangping Zhong, Dapeng Wang
Publikováno v:
Cell Biochemistry and Biophysics. 76:83-90
The human pituitary tumor-transforming gene is an oncogenic protein which serves as a central hub in the cellular signaling network of medulloblastoma. The protein contains two vicinal PxxP motifs at its C terminus that are potential binding sites of
Autor:
Marissa Balmith, Mahmoud E. S. Soliman
Publikováno v:
Cell Biochemistry and Biophysics. 75:65-78
The first account of the dynamic features of the loop region of VP40 of the Ebola virus was studied using accelerated molecular dynamics simulations and reported herein. Among the proteins of the Ebola virus, the matrix protein (VP40) plays a signifi
Publikováno v:
Cell Biochemistry and Biophysics. 75:49-64
Human immunodeficiency virus (HIV)-negative factor (Nef) protein is an accessory pathogenic factor, which plays a significant role in acquired immune deficiency syndrome (AIDS). Nef deficient HIV virus took a longer time to progress into AIDS. Theref
Publikováno v:
Cell biochemistry and biophysics. 77(4)
Influenza virus is known for its intermittent outbreaks affecting billions of people worldwide. Several neuraminidase inhibitors have been used in practice to overcome this situation. However, advent of new resistant mutants has limited its clinical
Publikováno v:
Cell biochemistry and biophysics. 77(3)
Covalent inhibition targeting noncatalytic residues is rapidly gaining attention in drug discovery. Protein tyrosine phosphatases 1B (PTP1B) is an attractive target for therapeutic interventions in cancer and other diseases. Two binding sites of PTP1
Publikováno v:
Cell Biochemistry and Biophysics. 74:285-296
Cytokine interleukin-11 (IL-11) is a multifunctional protein with diverse roles in the normal cell signaling and in various pathologies. The structure of IL-11 is characterized by a four-helix bundle motif comprising two pairs of antiparallel α-heli
Publikováno v:
Cell biochemistry and biophysics. 76(3)
The prevalence of metal dysregulation in many neurodegenerative and neurocognitive disorders has compelled many studying such diseases to investigate the mechanisms underlying metal regulation in the central nervous system. Metal homoeostasis is ofte