Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jennifer A. Wargo"'
Publikováno v:
Cell
Unprecedented advances have been made in cancer treatment with the use of immune checkpoint blockade (ICB). However, responses are limited to a subset of patients, and immune-related adverse events (irAEs) can be problematic, requiring treatment disc
Autor:
Eiko Hayase, Tomo Hayase, Mohamed A. Jamal, Takahiko Miyama, Chia-Chi Chang, Miriam R. Ortega, Saira S. Ahmed, Jennifer L. Karmouch, Christopher A. Sanchez, Alexandria N. Brown, Rawan K. El-Himri, Ivonne I. Flores, Lauren K. McDaniel, Dung Pham, Taylor Halsey, Annette C. Frenk, Valerie A. Chapa, Brooke E. Heckel, Yimei Jin, Wen-Bin Tsai, Rishika Prasad, Lin Tan, Lucas Veillon, Nadim J. Ajami, Jennifer A. Wargo, Jessica Galloway-Peña, Samuel Shelburne, Roy F. Chemaly, Lauren Davey, Robert W.P. Glowacki, Chen Liu, Gabriela Rondon, Amin M. Alousi, Jeffrey J. Molldrem, Richard E. Champlin, Elizabeth J. Shpall, Raphael H. Valdivia, Eric C. Martens, Philip L. Lorenzi, Robert R. Jenq
Publikováno v:
Cell. 185:3705-3719.e14
The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT). Broad-spectrum antibiotics such as carbapenems increase the risk for inte
Autor:
Lei Feng, Maria Fernanda Montiel, Joseph F. Petrosino, Michael P. Kim, Matthew H.G. Katz, Ching Wei D. Tzeng, Samir M. Hanash, Wenli Dong, Pompeyo R. Quesada, Michelle Zoltan, Jennifer A. Wargo, Hanwen Xu, Ravid Straussman, Ismet Sahin, Yu Zhang, Vidhi Chandra, Jared K. Burks, Deborah Nejman, Cynthia L. Sears, Nadim J. Ajami, Anirban Maitra, Paul Scheet, Christine B. Peterson, Kim Anh Do, Robert R. Jenq, Liangliang Zhang, Florencia McAllister, Laura D. Wood, Anthony San Lucas, Erick Riquelme, James R. White
Publikováno v:
Cell
Most patients diagnosed with resected pancreatic adenocarcinoma (PDAC) survive less than 5 years, but a minor subset survives longer. Here, we dissect the role of the tumor microbiota and the immune system in influencing long-term survival. Using 16S
Autor:
Cloud P. Paweletz, Vancheswaran Gopalakrishnan, Sangeetha M. Reddy, Stacey L. Bjorgaard, Elena Ivanova, Keren Yizhak, Gad Getz, Genevieve M. Boland, Alexandre Reuben, Nir Hacohen, Jennifer A. Wargo, David A. Barbie, Michal Barzily-Rokni, Shauna M. Blackmon, Jean Pierre Eliane, Russell W. Jenkins, John P. Ray, Andrew Portell, Patrick H. Lizotte, Jonathan H. Chen, Bo Li, Amir Reza Aref, David J. Lieb, Moshe Sade-Feldman, Carl G. de Boer, Alexandra-Chloé Villani, Hans Vitzthum, Dennie T. Frederick, Zachary A. Cooper, Paul Hoover, Samuel S. Freeman, Ryan J. Sullivan, Marc R. Hammond, Keith T. Flaherty, Anat Stemmer-Rachamimov
Publikováno v:
Cell. 175(4)
Treatment of cancer has been revolutionized by immune checkpoint blockade therapies. Despite the high rate of response in advanced melanoma, the majority of patients succumb to disease. To identify factors associated with success or failure of checkp
Autor:
Yang Zhao, Miles C. Andrews, Jennifer A. Wargo, Dana Pe'er, Alexandria P. Cogdill, Jing Wang, Jacob H. Levine, James P. Allison, Padmanee Sharma, Spencer C. Wei, Nana Ama A.S. Anang
Publikováno v:
Cell. 170(6)
Immune-checkpoint blockade is able to achieve durable responses in a subset of patients; however, we lack a satisfying comprehension of the underlying mechanisms of anti-CTLA-4- and anti-PD-1-induced tumor rejection. To address these issues, we utili
Autor:
Nicolas Stransky, Guo Chen, Jeffrey E. Gershenwald, Daniel Auclair, Gad Getz, Andrey Sivachenko, Michael S. Noble, Daniel DiCara, Katherine Stemke-Hale, Eran Hodis, Eric S. Lander, Robert C. Onofrio, Dirk Schadendorf, Kristin G. Ardlie, Nikhil Wagle, Gregory V. Kryukov, Liren Li, Donald L. Morton, Stefan T. Arold, Douglas Voet, Kristian Cibulskis, Alex H. Ramos, Elizabeth Nickerson, Levi A. Garraway, Lynda Chin, Michael A. Davies, Wendy Winckler, Ian R. Watson, Kelly Chong, John E. Ladbury, Matthew Meyerson, Stacey Gabriel, Stephan N. Wagner, Jean Philippe Theurillat, Dave S.B. Hoon, Marcin Imielinski, Michael S. Lawrence, Jennifer A. Wargo, Chelsea S. Place, Gordon Saksena
Publikováno v:
Cell. 150:251-263
Summary Despite recent insights into melanoma genetics, systematic surveys for driver mutations are challenged by an abundance of passenger mutations caused by carcinogenic UV light exposure. We developed a permutation-based framework to address this
Autor:
Jianfeng Chen, Pei Ling Chen, Hao Zhao, Jianjun Gao, Jason Roszik, James P. Allison, Padmanee Sharma, Chantale Bernatchez, Patrick Hwu, Jennifer A. Wargo, Lewis Zhichang Shi, Qiuming He, Liangwen Xiong, Tenghui Chen, Scott E. Woodman, Andrew Futreal
Publikováno v:
Cell. 167:397-404.e9
Antibody blockade of the inhibitory CTLA-4 pathway has led to clinical benefit in a subset of patients with metastatic melanoma. Anti-CTLA-4 enhances T cell responses, including production of IFN-γ, which is a critical cytokine for host immune respo