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Publikováno v:
Cardiovasc Res
Ageing is the most significant contributor to the increasing prevalence of atrial fibrillation (AF). The gut microbiota dysbiosis is involved in age-related diseases. However, whether the aged-associated dysbiosis contributes to age-related AF is sti
Autor:
Sisareuth Tan, Jean-Sébastien Silvestre, Kamaleswaran Keirththana, Alain Brisson, Thi Anh-Dao Tran, José Vilar, Philippe Menasché, Paul Alayrac, Thomas Hamada, Maria Franca Perotto, Nadia El Harane, Reem Al-Daccak, Dominique Charron, Laetitia Pidial, Valérie Bellamy, Nisa Renault, Hocine Rachid Hocine, Chloé Guillas, Manon Desgres, Ingrid Gomez, Bruna Lima Correa
Publikováno v:
Cardiovascular Research
Cardiovascular Research, Oxford University Press (OUP), 2020, pp.cvaa028. ⟨10.1093/cvr/cvaa028⟩
Cardiovascular Research, 2020, pp.cvaa028. ⟨10.1093/cvr/cvaa028⟩
Cardiovascular Research, Oxford University Press (OUP), 2020, pp.cvaa028. ⟨10.1093/cvr/cvaa028⟩
Cardiovascular Research, 2020, pp.cvaa028. ⟨10.1093/cvr/cvaa028⟩
AimsThe cardioprotective effects of human induced pluripotent stem cell-derived cardiovascular progenitor cells (CPC) are largely mediated by the paracrine release of extracellular vesicles (EV). We aimed to assess the immunological behaviour of EV-C
Autor:
Vincenzo Calderone, Maria Cristina Breschi, Miren Josune Canduela, Paolo Ambrosino, Alma Martelli, Vincenzo Barrese, Michael J. Curtis, Lara Testai, Maria Josè Sisalli, Iolanda Vinciguerra, Maurizio Taglialatela, Antonella Scorziello, Pedro Grandes, Iain A. Greenwood, Francesco Miceli, Maria Virginia Soldovieri
Publikováno v:
Testai, L, Barrese, V, Soldovieri, M V, Ambrosino, P, Martelli, A, Vinciguerra, I, Miceli, F, Greenwood, I A, Curtis, M J, Breschi, M C, Sisalli, M J, Scorziello, A, Canduela, M J, Grandes, P, Calderone, V & Taglialatela, M 2016, ' Expression and function of Kv7.4 channels in rat cardiac mitochondria : Possible targets for cardioprotection ', Cardiovascular Research, vol. 110, no. 1, pp. 40-50 . https://doi.org/10.1093/cvr/cvv281
Aims: Plasmalemmal Kv7.1 (KCNQ1) channels are critical players in cardiac excitability; however, little is known on the functional role of additional Kv7 family members (Kv7.2-5) in cardiac cells. In this work, the expression, function, cellular and
Autor:
Laura Moreno, Juan Duarte, Rachele Pandolfi, Daniel Morales-Cano, Eduardo Villamor, Virginia Chamorro, Angel Cogolludo, Rosario Jiménez, Bianca Barreira, Francisco Perez-Vizcaino
Publikováno v:
Cardiovascular Research, 106(1), 98-108. Oxford University Press
Aims Voltage-gated potassium channels encoded by KCNQ genes (Kv7 channels) are emerging as important regulators of vascular tone. In this study, we analysed the contribution of Kv7 channels to the vasodilation induced by hypoxia and the cyclic AMP pa
Autor:
Thomas Jespersen, Jakob D. Nissen, Martin N. Andersen, Xiaodong Wang, Kevin Wickman, Morten Laursen, Bo Liang, Morten Grunnet, Lasse Skibsbye, Hanne B. Rasmussen, Matthew C. Hearing, Søren-Peter Olesen
Publikováno v:
Cardiovascular Research. 101:175-184
Aims The purpose of this study was to investigate the functional role of G-protein-coupled inward rectifier potassium (GIRK) channels in the cardiac ventricle. Methods and results Immunofluorescence experiments demonstrated that GIRK4 was localized i
Autor:
Jeremy P.T. Ward, Ievgen V. Strielkov, Igor V. Kizub, Silke Becker, Jesus Prieto-Lloret, Anatoly Soloviev, Yasin Shaifta, Philip I. Aaronson, Vladimir A. Snetkov
Publikováno v:
Kizub, I V, Strielkov, I V, Shaifta, Y, Becker, S, Prieto-Lloret, J, Snetkov, V A, Soloviev, A I, Aaronson, P I & Ward, J P T 2013, ' Gap junctions support the sustained phase of hypoxic pulmonary vasoconstriction by facilitating calcium sensitization ', Cardiovascular Research, vol. 99, no. 3, pp. 404-411 . https://doi.org/10.1093/cvr/cvt129
Cardiovascular Research
Cardiovascular Research
Aims: To determine the role of gap junctions (GJ) in hypoxic pulmonary vasoconstriction (HPV).Methods and results: Studies were performed in rat isolated intrapulmonary arteries (IPA) mounted on a myograph, and in anesthetized rats. Hypoxia induced a
Autor:
Hirokuni Arai, Shuki Mizutani, Susumu Muto, Akiko Itai, Akihito Sasaki, Go Haraguchi, Shozaburo Doi, Susumu Hosokawa, Mitsuaki Isobe
Publikováno v:
Cardiovascular Research. 99:35-43
Aims Proliferation of pulmonary arterial smooth muscle cells (PASMCs) is one histological sign of pulmonary arterial hypertension (PAH). We hypothesized that a signalling cascade from fibroblast growth factor 2 (FGF2) to plasminogen activator inhibit
Autor:
Anthie Ellis, Caryl E. Hill, Daniel J. Chaston, Hee-Sup Shin, Pernille B. Lærkegaard Hansen, Lauren Howitt, Ivana Y. Kuo
Publikováno v:
Howitt, L, Kuo, I Y, Ellis, A, Chaston, D J, Shin, H-S, Hansen, P B & Hill, C E 2013, ' Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles ', Advances in Cardiovascular Research, vol. 98, no. 3, pp. 449-457 . https://doi.org/10.1093/cvr/cvt043
Aims As cardiovascular disease is characterized by reduced nitric oxide bioavailability, our aim was to determine the impact of this change on the mechanism underlying vascular tone of pressurized arteries in vitro and in vivo . Methods and results W
Publikováno v:
Cardiovascular Research. 97:331-338
Aims Arterial stiffness is accelerated in type 1 diabetic patients. Medial artery calcification (MAC) contributes to the development of arterial stiffness. Vitamin K oxidoreductase (VKOR) reduces the vitamin K required by γ -carboxylase to activate
Autor:
Liyan Zhang, Phing-How Lou, Petra C. Kienesberger, Michael Zaugg, Eliana Lucchinetti, Alexander S. Clanachan, Andreas Affolter, Markus Heck, Manoj Gandhi, Martin Hersberger
Publikováno v:
Cardiovascular Research. 97:251-261
Aims Infarct-remodelled hearts are less amenable to protection against ischaemia/reperfusion. Understanding preservation of energy metabolism in diseased vs. healthy hearts may help to develop anti-ischaemic strategies effective also in jeopardized m