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Autor:
Felipe Martinez
Publikováno v:
Cardiovascular Drugs and Therapy. 24:345-350
Aldosterone is present and active all along the cardiovascular continuum. Excessive tissue production occurs in cardiovascular diseases including myocardial infarction (MI) and heart failure, resulting in a multitude of adverse effects in the cardiov
Autor:
Hicran Cil, Bunyamin Yavuz, Emre Tutal, Kursad Dal, Naim Ata, Murat Sevket Hokkaomeroglu, Kadir Okhan Akin, Derun Taner Ertugrul, Metin Kucukazman, Ahmet Arif Yalcin, Burcu Balam Yavuz
Publikováno v:
Cardiovascular Drugs and Therapy. 23:295-299
Low levels of 25-hydroxyvitamin D are associated with higher risk of cardiovascular morbidity and mortality. Large trials demonstrated that statins significantly decrease cardiovascular morbidity and mortality. 7-dehydrocholesterol is the precursor o
Autor:
G.B. John Mancini
Publikováno v:
Cardiovascular Drugs and Therapy. 10:609-612
Angiotensin-converting enzyme (ACE) inhibitors have played a highly beneficial role in the therapy of hypertension and congestive heart failure. Detailed analysis of some of the heart failure trials in patients with these diseases has uncovered unexp
Publikováno v:
Cardiovascular drugs and therapy. 27(1)
Our early work showed that the estrogen metabolite 2-methoxyestradiol (2ME) inhibits proliferation of vascular smooth muscle cells (SMCs) and vascular contractility through an endothelium-dependent mechanism. The aim of this study was to examine whet
Publikováno v:
Cardiovascular Drugs and Therapy. 9:509-523
Hypertension is an important cardiovascular risk factor. High blood pressure per se is not a disease but a hemodynamic alteration associated with vascular disease. Two classes of drugs are especially effective in lowering blood pressure and preventin
Publikováno v:
Cardiovascular Drugs and Therapy. 8:509-513
During a double-blind, randomized study in hypertensive patients, changes in plasma lipid and lipoprotein levels during treatment with celiprolol were compared with those occurring during nifedipine treatment. Fifty-three patients (28 men and 25 wome
Publikováno v:
Cardiovascular drugs and therapy. 24(4)
Angiotensin-converting enzyme (ACE) inhibitors improve outcomes in patients with coronary artery disease (CAD), heart failure, and hypertension. This short review examines clinical evidence for such effects and the underlying mechanism of action. One
Publikováno v:
Cardiovascular Drugs and Therapy. 6:261-265
The effect of enalapril alone and in combination with nadolol on resting and exercising blood pressure, heart rate, plasma renin activity, aldosterone, noradrenaline, and potassium levels was studied in 10 hypertensive patients (diastolic blood press
Publikováno v:
Cardiovascular drugs and therapy. 21(3)
The management of the hypercholesterolemic patient has evolved tremendously with the introduction of the HMG-CoA Reductase inhibitors, a class of drugs better known as the statins. Statins modify cholesterol metabolism by inhibiting the rate-limiting
Autor:
Yoshihiro Asano, Akio Hirata, Hitonobu Tomoike, Yasunori Shintani, Seiji Takashima, Shoji Sanada, Satoru Yamasaki, Masafumi Kitakaze, Tetsuo Minamino, Osamu Tsukamoto, Ken-ichiro Okada, Masatsugu Hori, Masashi Fujita, Liao Yulin
Publikováno v:
Cardiovascular drugs and therapy. 20(2)
Aldosterone promotes cardiovascular inflammation and remodeling, both of which are characteristic changes in hypertensive and failing hearts. Since chronic inhibition of nitric oxide (NO) synthase with N(omega)-nitro-L-arginine methyl ester (L-NAME)