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Atorvastatin Protects against Ischemia-Reperfusion Injury in Fructose-Induced Insulin Resistant Rats
Autor:
Prem Prakash, Vivek Khanna, Manoj Kumar Barthwal, Vishal Singh, Anupam Jyoti, Manish Jain, Ravi S. Keshari, Madhu Dikshit
Publikováno v:
Cardiovascular Drugs and Therapy. 25:285-297
High fructose (HFr) intake is known to cause insulin resistance syndrome (IRS), however its effect against acute coronary events remains elusive. The present study was undertaken to evaluate the effect of HFr (60%) diet on myocardial ischemia-reperfu
Autor:
Felipe Martinez
Publikováno v:
Cardiovascular Drugs and Therapy. 24:345-350
Aldosterone is present and active all along the cardiovascular continuum. Excessive tissue production occurs in cardiovascular diseases including myocardial infarction (MI) and heart failure, resulting in a multitude of adverse effects in the cardiov
Autor:
Yousuke Mori, Shigefumi Nakano, Shigeo Horinaka, Hiroshi Yagi, Koutarou Yoshida, Naohiko Kobayashi, Hiroshi Asakawa, Akihisa Yabe, Yusuke Tsubokou, Hiroaki Matsuoka
Publikováno v:
Cardiovascular Drugs and Therapy. 18:13-22
Nicorandil is an adenosine triphosphate sensitive K (K-ATP) channel opener and a nitric oxide donor. K-ATP channels and nitric oxide are important factors in ischemic preconditioning, which in turn suppresses reperfusion arrhythmias. The present stud
Autor:
Eftihia Sbarouni, Christos Kroupis, Panagiota Flevari, K. Koniavitou, Zenon S. Kyriakides, Dimitrios Th. Kremastinos
Publikováno v:
Cardiovascular Drugs and Therapy. 17:319-323
Purpose: Raloxifene is a selective estrogen receptor modulator and an attractive alternative to estrogen replacement as it obviates the need for a progestin and does not increase C-reactive protein levels. We compared the effects of simvastatin and r
Publikováno v:
Cardiovascular Drugs and Therapy. 15:301-307
Enhanced platelet activity and platelet endothelial interaction are hallmarks of different vascular and metabolic diseases with subsequent thrombus formation. In atherosclerosis, coronary artery disease, congestive heart failure, nitrate tolerance, c
Publikováno v:
Cardiovascular Drugs and Therapy. 14:23-29
Vascular ATP-dependent potassium (K+ATP) channels open and contribute to reactive hyperemia (RH) in animals. The contribution of K+ATP channels to ischemic vasolidation during RH and interactions with endothelium-derived nitric oxide have not been we
Publikováno v:
Cardiovascular Drugs and Therapy. 12:279-284
Several authors have alluded to the possible involvement of EDRF (NO) in ischemia-induced coronary artery dilation. Alternatively, it has been suggested that opening of ATP-dependent K channels could play a key role in this context. We studied the ef
Publikováno v:
Cardiovascular Drugs and Therapy. 11:435-440
Oxygen-derived free radicals are believed to be involved in diabetes-induced vascular complications. The role of oxygen radicals in endothelial dysfunction in diabetes is not known with certainty. In this study we tested whether inhibition of lipid p
Publikováno v:
Cardiovascular Drugs and Therapy. 10:557-560
As damage to the pulmonary vascular endothelium may be responsible for the lung toxicity of amiodarone, we evaluated the cytolytic toxicity of the drug in cultures of endothelial cells. Cells were cultured from human umbilical cord veins. Amiodarone
Publikováno v:
Cardiovascular drugs and therapy. 24(4)
Angiotensin-converting enzyme (ACE) inhibitors improve outcomes in patients with coronary artery disease (CAD), heart failure, and hypertension. This short review examines clinical evidence for such effects and the underlying mechanism of action. One