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Publikováno v:
Cardiovascular Drugs and Therapy. 32:223-232
Inflammation participates in the initiation and progression of atherosclerotic cardiovascular disease, and it is a critical inciting factor leading to acute ischemic events. Evidence has shown that certain anti-inflammatory medications used to treat
Autor:
Eric J. Niesor, David Kallend, Gabriela Bucklar-Suchankova, Markus Abt, Andrea Stauffer, Gregory G. Schwartz, Alexandre Durrwell, Renée Benghozi, Anne Perez
Publikováno v:
Cardiovascular Drugs and Therapy. 29:7-14
Cholesterol efflux from macrophages to HDL, measured in vitro, is augmented by treatment with agents which raise HDL cholesterol. In vitro, cholesterol depletion by statins is known to trigger a positive feedback on the cholesterol synthetic pathway
Autor:
Alvaro Cerda, Mario Hiroyuki Hirata, Tomás Zambrano, Luis A. Salazar, Rosario Dominguez Crespo Hirata
Publikováno v:
Cardiovascular drugs and therapy. 29(6)
Statins are widely prescribed drugs to manage hypercholesterolemia. Despite they are considered effective lipid-lowering agents, significant inter-individual variability has been reported in relation to drug response. Among the reasons explaining thi
Publikováno v:
Cardiovascular Drugs and Therapy. 24:359-367
Smoking continues to be a major contributor to the burden of disease across the world although there has been a decrease in some developed countries such as USA and Australia. In countries of South-East Asia with a high prevalence of smoking, the inc
Autor:
Seung Uk Lee, Kyu Hyung Ryu, Hyo-Soo Kim, Dong-Ju Choi, Young Jo Kim, Sang-Hyun Ihm, Seung Ho Hur, Doo Il Kim, Dae Gyun Park, Bum-soo Kim, Sang Hoon Lee, Young Jin Choi, Yangsoo Jang, Ki Bae Seung, Tae Hoon Ahn, Soon Jun Hong, Taek Jong Hong, Cheol Whan Lee, Jang Ho Bae, Sang Hong Baek, Young Keun Ahn
Publikováno v:
Cardiovascular Drugs and Therapy. 24:181-188
This study was designed to evaluate the safety and efficacy of algorithm-based atorvastatin therapy initiated at different starting doses of 10, 20, and 40 mg in Korean dyslipidemic patients.Five hundred seventy-four patients were screened, and 425 w
Publikováno v:
Cardiovascular Drugs and Therapy. 18:127-134
Bradykinin is an important endogenous trigger of myocardial ischemic preconditioning (IPC). Through simultaneous inhibition of neutral endopeptidase and angiotensin converting enzyme, omapatrilat prevents enzymatic degradation of bradykinin. The aim
Autor:
Yousuke Mori, Shigefumi Nakano, Shigeo Horinaka, Hiroshi Yagi, Koutarou Yoshida, Naohiko Kobayashi, Hiroshi Asakawa, Akihisa Yabe, Yusuke Tsubokou, Hiroaki Matsuoka
Publikováno v:
Cardiovascular Drugs and Therapy. 18:13-22
Nicorandil is an adenosine triphosphate sensitive K (K-ATP) channel opener and a nitric oxide donor. K-ATP channels and nitric oxide are important factors in ischemic preconditioning, which in turn suppresses reperfusion arrhythmias. The present stud
Publikováno v:
Cardiovascular Drugs and Therapy. 17:249-255
Monocyte chemoattractant protein-1 (MCP-1) and vascular endothelial growth factor (VEGF) stimulate angiogenesis in ischemic tissues, and both of their expression are stimulated by angiotensin II. We measured the serum concentrations of MCP-1 and VEGF
Publikováno v:
Cardiovascular Drugs and Therapy. 17:25-30
Previous studies have suggested that the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors attenuate ischemia-reperfusion injury by increasing the activity of endothelial nitric oxide synthase (eNOS). We assessed whether short-term
Autor:
John D. Horowitz, Doan T.M. Ngo, Wai Ping A. Chan, Cher-Rin Chong, Nathan E.K. Procter, Yuliy Y. Chirkov, Thanh H Nguyen, Saifei Liu, Aaron L. Sverdlov
Publikováno v:
Cardiovascular drugs and therapy. 28(4)
The thioredoxin system, which consists of thioredoxin (Trx), nicotinamide adenine dinucleotide phosphate (NADPH) and thioredoxin reductase (TrxR), has emerged as a major anti-oxidant involved in the maintenance of cellular physiology and survival. Dy