Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Mohammad Faujul Kabir, Jazmyne L Jackson, Annie D Fuller, Leonny Gathuka, Adam L Karami, Don-Gerard Conde, Alena Klochkova, Anbin Mu, Kathy Q Cai, Andres J Klein-Szanto, Amanda B Muir, Kelly A Whelan
Publikováno v:
Carcinogenesis. 44:182-195
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive forms of human malignancy, often displaying limited therapeutic response. Here, we examine the non-steroidal anti-inflammatory drug diclofenac (DCF) as a novel therapeutic agent
Autor:
Jeffrey J Headd, Kathy N. Williams, Jacqueline B Plesset, Ashley A. Lento, Rosemarie Mick, Andres J. Klein-Szanto, Priya Chatterji, Rei Mizuno, Anil K. Rustgi, Sarah F. Andres, Kathryn E. Hamilton
Publikováno v:
Carcinogenesis
The RNA-binding protein insulin-like growth factor 2 mRNA binding protein 1 (IMP1) is overexpressed in colorectal cancer (CRC); however, evidence for a direct role for IMP1 in CRC metastasis is lacking. IMP1 is regulated by let-7 microRNA, which bind
Autor:
Kathryn E. Hamilton, Koji Tanaka, Veronique Giroux, Hiroshi Nakagawa, Marie Pier Tetreault, Ju Seog Lee, Apple Long, Andres J. Klein-Szanto, Anil K. Rustgi, Kelly A. Whelan
Publikováno v:
Carcinogenesis. 36:598-606
Esophageal cells overexpressing epidermal growth factor receptor (EGFR) and TP53 mutation can invade into the extracellular matrix when grown in 3D-organotypic cultures (OTC) and mimic early invasion in esophageal squamous cell carcinoma (ESCC). We h
Publikováno v:
Carcinogenesis. 23:565-572
Proprotein convertases (PCs) have been implicated in tumor cell invasion by processing a variety of substrates including matrix metalloproteinases (MMPs). PACE4, a member of the family of PCs was shown to enhance mouse skin carcinoma progression by i
Autor:
Gabrielle S. Wong, Mitsuteru Natsuizaka, Meenhard Herlyn, J. Alan Diehl, Hiroshi Nakagawa, Shinya Ohashi, Andres J. Klein-Szanto, Daniela Budo, Ross A. Kalman, Azal Ahmadi
Publikováno v:
Carcinogenesis. 31(8)
Insulin-like growth factor-binding protein (IGFBP)-3 is overexpressed frequently in esophageal squamous cell carcinoma. Yet, the role of IGFBP3 in esophageal tumor biology remains to be elucidated. We find that IGFBP3 facilitates transforming growth
Autor:
Michael Unger, Robert E. Page, Hao Wang, Yasuhiro Mitsuuchi, Andres J. Klein-Szanto, Binaifer R. Balsara, Jianming Pei, Joseph R. Testa
Publikováno v:
Carcinogenesis. 25(11)
AKT is frequently activated in various cancers, but its involvement in lung tumor development and progression is not well established. We examined AKT activity by immunohistochemistry in 110 non-small cell lung carcinomas (NSCLCs) using tissue microa
Autor:
John A. Ridge, Deborah B. Cleveland, Andres J. Klein-Szanto, Edward R. Sauter, Bruce J. Trock
Publikováno v:
Carcinogenesis. 15(10)
To identify the stage in head and neck carcinogenesis at which p53 abnormalities become important, we evaluated 512 squamous epithelial tissue samples (201 pre-invasive and 209 invasive lesions, as well as 102 normal epithelia) in specimens from two
Publikováno v:
Carcinogenesis. 15(8)
In this report, we describe the isolation and characterization of six murine squamous cell carcinoma cell lines (BPCC) derived from carcinomas produced by a complete carcinogenesis protocol with benzo[a]pyrene (B[a]P). All six cell lines were tumorig
Autor:
S. Momiki, T. Iizasa, Jorge Caamano, Andres J. Klein-Szanto, J. Lechner, C.C. Harris, B. Bauer, R. Metcalf
Publikováno v:
Carcinogenesis. 14(9)
Several chemicals that are found in cigarette smoke or diesel oil engine exhausts, such as benzo[a]pyrene (B[a]P) and 1,6-dinitropyrene (DNP) are carcinogenic in experimental animal models. In the present study, we have exposed in vivo the xenotransp
Publikováno v:
Carcinogenesis. 10(11)
Spindle cell carcinomas were identified using polyacrylamide gel electrophoresis and immunoblotting of proteins extracted from paraffin-embedded tissue sections. Immunohistochemistry using rabbit monospecific antisera against the mouse 55 kd keratin