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Publikováno v:
Carcinogenesis
Despite advances in molecular characterization of glioblastoma multiforme (GBM), only a handful of predictive biomarkers exist with limited clinical relevance. We aimed to identify differentially expressed genes in tumor samples collected at surgery
Publikováno v:
Carcinogenesis
The US Preventive Services Task Force (USPSTF) recently proposed to widen the current lung cancer screening guideline to include less-heavy smokers. We sought to incorporate both genetic and tobacco smoking data to evaluate the proposed new guideline
Autor:
Kang Wang, Yun-Bing Wang, Guo-Chao Zhong, Peng-Fei Yang, Jing-Jing Wu, Fa-Bao Hao, Jie-Jun Hu, Qu-Jin Li
Publikováno v:
Carcinogenesis. 42:724-732
Low-carbohydrate diets have become a popular approach for weight loss in recent years. However, whether low-carbohydrate diets are associated with the risk of pancreatic cancer remains to be elucidated. Hence, we examined the association of low-carbo
Publikováno v:
Carcinogenesis. 42(10)
Phytoestrogens (PEs) have estrogen-like activity and were found to lower incidences of several hormone-dependent cancers. Emerging evidence suggests that estrogen may play a role in lung cancer carcinogenesis. We aim to evaluate dietary PE intake and
Autor:
Yu-Wei Chiu, Pei-Yin Chen, Shun-Fa Yang, Lun-Ching Chang, Yi-Tzu Chen, Chun-Yi Chuang, Hsien Da Huang, Chih-Yu Peng, Ming-Yi Lu, Shih-Chi Su
Publikováno v:
Carcinogenesis. 42(1)
Dysbiosis of oral microbiome may dictate the progression of oral squamous cell carcinoma (OSCC). Yet, the composition of oral microbiome fluctuates by saliva and distinct sites of oral cavity and is affected by risky behaviors (smoking, drinking and
Autor:
Mulong Du, Haiyan Chu, Kaili Xu, Yuan Wu, Yixuan Meng, Lingjun Zhu, Dongying Gu, Zhengdong Zhang, Meilin Wang, Shuwei Li, Zan Fu
Publikováno v:
Carcinogenesis.
The N6-methyladenosine (m6A) modification plays important regulatory roles in gene expression, cancer occurrence and metastasis. Herein, we aimed to explore the association between genetic variants in m6A modification genes and susceptibility to colo
Autor:
Paal Romundstad, Serena Nik-Zainal, Per Eystein Lønning, Stian Knappskog, Liv Beathe Gansmo, Lars J. Vatten, Kristian Hveem
Publikováno v:
Carcinogenesis
The germline ‘APOBEC3A/B’ deletion polymorphism, previously linked to APOBEC-dependent mutational signatures, was found associated with lung cancer risk among young individuals and age at diagnosis for lung and prostate cancer. No associations we
Publikováno v:
Carcinogenesis. 38:1021-1028
Metastases in the later stages of hepatocellular carcinoma (HCC) cause the majority of deaths associated with the disease, making early detection crucial to patient survival. Risk models assessing HCC risk in the general population can be used for ri
Autor:
Sharon E. Murphy, Sungshim L. Park, Yesha Patel, Maarit Tiirikainen, Loic Le Marchand, Daniel O. Stram, Lynne R. Wilkens
Publikováno v:
Carcinogenesis. 37:269-279
Genetic variation in cytochrome P450 2A6 (CYP2A6) gene is the primary contributor to the intraindividual and interindividual differences in nicotine metabolism and has been found to influence smoking intensity. However, no study has evaluated the rel
Autor:
Leo J. Schouten, Marjolein H.F.M. Lentjes, Hubert J.M. Smeets, Matty P. Weijenberg, Piet A. van den Brandt, Colinda C. J. M. Simons, Ralph W.H. Gottschalk, A.M. Voets, Manon van Engeland, Frits H.M. van Osch
Publikováno v:
Carcinogenesis, 36(12), 1502-1510. Oxford University Press
Low mitochondrial DNA (mtDNA) copy number in tumors has been associated with worse prognosis in colorectal cancer (CRC). This study further deciphers the role of mtDNA copy number in CRC by comparing mtDNA copy number between healthy, adenoma and car