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Autor:
Yu-Wei Chiu, Pei-Yin Chen, Shun-Fa Yang, Lun-Ching Chang, Yi-Tzu Chen, Chun-Yi Chuang, Hsien Da Huang, Chih-Yu Peng, Ming-Yi Lu, Shih-Chi Su
Publikováno v:
Carcinogenesis. 42(1)
Dysbiosis of oral microbiome may dictate the progression of oral squamous cell carcinoma (OSCC). Yet, the composition of oral microbiome fluctuates by saliva and distinct sites of oral cavity and is affected by risky behaviors (smoking, drinking and
Publikováno v:
Carcinogenesis. 33:2398-2408
Mitogen-activated protein kinase (MAPK) pathways regulate many cellular functions including cell proliferation, differentiation, migration and apoptosis. We evaluate genetic variation in the c-Jun-N-terminal kinases, p38, and extracellular regulated
Autor:
Angela Cecilia Pesatori, Amy F. Subar, Melissa Rotunno, Neil E. Caporaso, Dario Consonni, Maria Teresa Landi, Laurie Burdette, Alisa M. Goldstein, Sholom Wacholder, Pier Alberto Bertazzi, Margaret A. Tucker, Tram Kim Lam, Jay H. Lubin, Stephen J. Chanock
Publikováno v:
Carcinogenesis. 31:634-642
Epidemiological and mechanistic evidence on the association of quercetin-rich food intake with lung cancer risk and carcinogenesis are inconclusive. We investigated the role of dietary quercetin and the interaction between quercetin and P450 and glut
Autor:
David Ryberg, David H. Phillips, Nina E. Landvik, Aage Haugen, Shanbeh Zienolddiny, Richard S. Houlston, Vidar Skaug
Publikováno v:
Carcinogenesis. 30:1368-1371
Genome-wide association studies have provided evidence that common variation at 5p15.33 [telomerase reverse transcriptase (TERT)-cleft lip and palate transmembrane 1-like (CLPTM1L)], 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) influences lung cancer risk and
Autor:
Mitchell Kronenberg, Nissi Varki, Robbin Newlin, Anna Olsson, Geetha Srikrishna, Hudson H. Freeze, Jonamani Nayak, Mien T. X. Nguyen, Pratima Sinha, Peter P. Nawroth, Thomas Vogl, Dirk Foell, Angelika Bierhaus, Olga Turovskaya
Publikováno v:
Carcinogenesis
Patients with inflammatory bowel diseases are at increased risk for colorectal cancer, but the molecular mechanisms linking inflammation and cancer are not well defined. We earlier showed that carboxylated N-glycans expressed on receptor for advanced
Autor:
Katherine D. Crew, Meenakshi Agrawal, Marilie D. Gammon, Alfred I. Neugut, Sharon K. Sagiv, Mary Beth Terry, Susan L. Teitelbaum, Sybil M. Eng, Regina M. Santella, Fang Fang Zhang
Publikováno v:
Carcinogenesis. 28:2548-2551
FAS and FAS ligand (FASL) play key roles in apoptotic signaling and down-regulation of this pathway may facilitate tumorigenesis. Alterations in apoptosis genes may affect cancer risk by influencing individual susceptibility to environmental carcinog
Autor:
Giovanni Fiorito, Stefano Bonassi, Marta Betti, Daniela Ferrante, Simonetta Guarrera, Elisabetta Casalone, Giuseppe Matullo, Sara Tunesi, Silvano Andorno, Corrado Magnani, Donatella Ugolini, Irma Dianzani, Dario Mirabelli, Monica Neri
Publikováno v:
Carcinogenesis. 36(10)
Asbestos exposure is the main risk factor for malignant pleural mesothelioma (MPM), a rare aggressive tumor. Nevertheless, on average less than 10% of subjects highly exposed to asbestos develop MPM, suggesting the possible involvement of other risk
Autor:
Anna Camoirano, Andrea Piana, Paolo Cossu Rocca, Bianca Maria Are, Ida Mura, Maria Pina Dore, Silvio De Flora, Alberto Izzotti, A Maida, Cristina Cartiglia, Maria Grazia Longobardi, Antonio Mario Scanu
Publikováno v:
Carcinogenesis. 28:892-898
Infection by Helicobacter pylori is the most important risk factor for gastric cancer. However, only a small fraction of colonized individuals, representing at least half of the world’s population, develop this malignancy. In order to shed light on
Autor:
Robert M. Chamberlain, Xiaodong Zhai, Qingyi Wei, Margaret R. Spitz, Guojun Li, Zhengdong Zhang
Publikováno v:
Carcinogenesis. 27:2028-2033
The MDM2 protein negatively regulates p53 expression level in modulating DNA repair, cell-cycle control, cell growth and apoptosis. Polymorphisms in the promoter region of the MDM2 gene have been shown to alter protein expression and may, thus, play
Publikováno v:
Carcinogenesis. 27:2070-2082
Human liver cancer, primarily hepatocellular carcinoma (HCC), is both common and lethal. Notable variation in HCC incidence rates worldwide corresponds to the prevalence and pattern of the primary etiologic factors. In summary of decades of collabora