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Autor:
Tony Fletcher, Nalini Srinivas, Peter Rudnai, Thomas Hielscher, Rajesh Kumar, Eugene Gurzau, Silvia Calderazzo, Kvetoslava Koppova, Sivaramakrishna Rachakonda
Publikováno v:
Carcinogenesis. 40:715-723
Telomere length per se a heritable trait has been reported to be associated with different diseases including cancers. In this study based on arsenic exposed 528 cases with basal cell carcinoma of skin (BCC) and 533 healthy controls, we observed a st
Autor:
Caitlin C. Jokipii Krueger, Yesha Patel, Daniel O. Stram, Natalia Y. Tretyakova, Guru Madugundu, Loic Le Marchand, S. Lani Park
Publikováno v:
Carcinogenesis
1,3-Butadiene (BD) is a known human carcinogen used in the synthetic polymer industry and also found in cigarette smoke, automobile exhaust and wood burning smoke. BD is metabolically activated by cytochrome P450 monooxygenases (CYP) 2E1 and 2A6 to 3
Publikováno v:
Carcinogenesis. 38(12)
Recent studies indicate that abnormal levels of low-density lipoprotein (LDL), which is an important component of dyslipidaemia, are associated with alterations to cancer risk, including that of renal cell carcinoma (RCC). Single nucleotide polymorph
Autor:
Yasuhiko Ozaki, Tatsuya Toyama, Takayuki Tsukuba, Kuniaki Okamoto, Seiji Nakamura, Atsushi Yasukochi, Satoru Takahashi, Hiroko Yamashita, Tomoyo Kawakubo, Kenji Yamamoto, Koichi Nishigaki
Publikováno v:
Carcinogenesis. 35(3):714-726
Despite advances in detection and treatment for breast cancer (BC), recurrence and death rates remain unacceptably high. Therefore, more convenient diagnostic and prognostic methods still required to optimize treatments among the patients. Here, we r
Autor:
Joel L. Weissfeld, Rashmi Sinha, Amanda J. Cross, Laura Burdett, Sonja I. Berndt, Richard B. Hayes, Barry I. Graubard, Leah M. Ferrucci, Elizabeth H. Ruder, Anne M.J. Gilsing
Publikováno v:
Carcinogenesis, 35(6), 1276-1283. Oxford University Press
Dietary iron intake and variation in iron homeostasis genes may affect colorectal neoplasia risk. We conducted two nested case–control studies within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial: one of advanced colorectal aden
Autor:
W. Boersma-van Ek, de Elisabeth G. E. Vries, Johannes Wesseling, D. M. Heijink, Jan J. Koornstra, Mathilde Jalving, Nynke Zwart, Jan H. Kleibeuker, de Steven Jong, Willem Sluiter
Publikováno v:
CARCINOGENESIS, 35(5), 1092-1099. Oxford University Press
Expression of the pro-apoptotic TRAIL receptors is regulated, at least in part, by beta-catenin. We show that beta-catenin co-localizes with DR4/5 in human and mouse colorectal tumours and that downregulation of beta-catenin in cell line models reduc
Autor:
Jeffrey A. Tice, Louise A. Brinton, Douglas C. Bauer, Cher M. Dallal, Trisha F. Hue, Andrea Z. LaCroix, Timothy D. Veenstra, Xia Xu, James V. Lacey, Diana S. M. Buist, Ruth M. Pfeiffer, Barbara J. Fuhrman, Roni T. Falk, Jane A. Cauley
Publikováno v:
Carcinogenesis. 35:346-355
Although elevated circulating estrogens are associated with increased postmenopausal breast cancer risk, less is known regarding the role of estrogen metabolism in breast carcinogenesis. We conducted a case-cohort study within the Breast and Bone Fol
Autor:
Ann Smeets, Carsten Kriebitzsch, Barbara Brouwers, T. Vandorpe, Marie-Rose Christiaens, Gilian Peuteman, Anne-Sophie Dieudonné, Olivier Brouckaert, Diether Lambrechts, Annouschka Laenen, Annemieke Verstuyf, Patrick Neven, Roger Bouillon, Lieve Verlinden, Sigrid Hatse, Robert Paridaens, Hans Wildiers
Publikováno v:
Carcinogenesis. 33:1319-1326
We correlated serum 25-hydroxyvitamin D3 (25OHD) levels with tumor characteristics and clinical disease outcome in breast cancer patients and assessed the impact of genetic determinants of vitamin D insufficiency. We collected serum from 1800 early b
Autor:
Norio Hayashi, Hiroyujki Masaoka, Satoyo Hosono, Miki Watanabe, Hidemi Ito, Akira Yokomizo, Masatoshi Eto, Isao Oze, Keitaro Matsuo, Norihito Soga, Hideo Tanaka
Publikováno v:
Carcinogenesis. 37(6)
Although a range of chemical exposures (cigarette smoking and occupational exposure) are recognized risk factors for the development of bladder cancer (BCa), many epidemiological studies have demonstrated that alcohol drinking is not associated with
Autor:
Gloria M. Petersen, William R. Bamlet, Samuel Antwi, Ann L. Oberg, Kari G. Chaffee, Susan E. Steck, J R Hebert, Nitin Shivappa
Publikováno v:
Carcinogenesis. 37(5)
Background: Pancreatic cancer (PanC) is a rapidly lethal malignancy with poorly understood etiology. Epidemiologic studies show strong associations between PanC and inflammatory conditions or stimuli such as cigarette smoking and diabetes, suggesting