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Autor:
Yaara Ber, David Margel, Rachel Ozlavo, Rinat Yerushalmi, Ahuvah Grubsrein, Adi Pomerantz, Tuval Sivan, Sharon Bargil, Yael Rapson, Eran Sharon, Opher Caspi, Daliah Tsoref
Publikováno v:
Carcinogenesis
Women who carry the BRCA mutation are at high lifetime risk of breast cancer, but there is no consensus regarding an effective and safe chemoprevention strategy. A large body of evidence suggests that 3,3-diindolylmethane (DIM), a dimer of indole-3-c
Publikováno v:
Carcinogenesis. 42(10)
Phytoestrogens (PEs) have estrogen-like activity and were found to lower incidences of several hormone-dependent cancers. Emerging evidence suggests that estrogen may play a role in lung cancer carcinogenesis. We aim to evaluate dietary PE intake and
Autor:
Caitlin C. Jokipii Krueger, Yesha Patel, Daniel O. Stram, Natalia Y. Tretyakova, Guru Madugundu, Loic Le Marchand, S. Lani Park
Publikováno v:
Carcinogenesis
1,3-Butadiene (BD) is a known human carcinogen used in the synthetic polymer industry and also found in cigarette smoke, automobile exhaust and wood burning smoke. BD is metabolically activated by cytochrome P450 monooxygenases (CYP) 2E1 and 2A6 to 3
Autor:
Wei Xu, Lawson Eng, Helen Mackay, Olusola Olusesan Faluyi, Rebecca Wong, Sharon Marsh, Jennifer J. Knox, Daniel J. Renouf, Qin Kuang, Geoffrey Liu, Nanjiao Ying, Sevtap Savas, Gail Darling, Qin Quinn Kong, Abul Kalam Azad, Lorin Dodbiba, Alvina Tse, Dangxiao Cheng, Xin Qiu
Publikováno v:
Carcinogenesis. 36:956-962
Polymorphisms in the vascular endothelial growth factor (VEGF)/angiogenesis pathway have been implicated previously in cancer risk, prognosis and response to therapy including in esophageal adenocarcinoma. Prior esophageal adenocarcinoma studies focu
Autor:
Leo J. Schouten, Janneke G. F. Hogervorst, Matty P. Weijenberg, Theo M. de Kok, Daisy de Bruijn-Geraets, Piet A. van den Brandt, R. Alexandra Goldbohm, Manon van Engeland
Publikováno v:
Carcinogenesis, 35(5), 1032-1038. Oxford University Press
Acrylamide, a probable human carcinogen, is present in heat-treated carbohydrate-rich foods. Epidemiological studies have not shown a clear association between acrylamide intake and colorectal cancer (CRC) risk. This may be due to the molecular heter
Autor:
Jeffrey A. Tice, Louise A. Brinton, Douglas C. Bauer, Cher M. Dallal, Trisha F. Hue, Andrea Z. LaCroix, Timothy D. Veenstra, Xia Xu, James V. Lacey, Diana S. M. Buist, Ruth M. Pfeiffer, Barbara J. Fuhrman, Roni T. Falk, Jane A. Cauley
Publikováno v:
Carcinogenesis. 35:346-355
Although elevated circulating estrogens are associated with increased postmenopausal breast cancer risk, less is known regarding the role of estrogen metabolism in breast carcinogenesis. We conducted a case-cohort study within the Breast and Bone Fol
Autor:
Briseis Aschebrook-Kilfoy, Donne Bennett D. Caces, Margaret E. Wright, Brian C.-H. Chiu, Nicholas J. Ollberding, Dennis D. Weisenburger, Sonali M. Smith
Publikováno v:
Carcinogenesis. 34:170-175
Greater consumption of red meat, processed meat and dairy products has been associated with an increased risk of non-Hodgkin lymphoma (NHL) in several previous reports. Phytanic acid, a saturated fatty acid obtained primarily through the consumption
Autor:
Ann Smeets, Carsten Kriebitzsch, Barbara Brouwers, T. Vandorpe, Marie-Rose Christiaens, Gilian Peuteman, Anne-Sophie Dieudonné, Olivier Brouckaert, Diether Lambrechts, Annouschka Laenen, Annemieke Verstuyf, Patrick Neven, Roger Bouillon, Lieve Verlinden, Sigrid Hatse, Robert Paridaens, Hans Wildiers
Publikováno v:
Carcinogenesis. 33:1319-1326
We correlated serum 25-hydroxyvitamin D3 (25OHD) levels with tumor characteristics and clinical disease outcome in breast cancer patients and assessed the impact of genetic determinants of vitamin D insufficiency. We collected serum from 1800 early b
Autor:
Norio Hayashi, Hiroyujki Masaoka, Satoyo Hosono, Miki Watanabe, Hidemi Ito, Akira Yokomizo, Masatoshi Eto, Isao Oze, Keitaro Matsuo, Norihito Soga, Hideo Tanaka
Publikováno v:
Carcinogenesis. 37(6)
Although a range of chemical exposures (cigarette smoking and occupational exposure) are recognized risk factors for the development of bladder cancer (BCa), many epidemiological studies have demonstrated that alcohol drinking is not associated with
Autor:
Peter G. Shields, Katherine L. Meeker, Marc Schwartz, Costanza Cocilovo, Kenshata M. Watkins, Shawna C. Willey, Celia Byrne, Yun-Ling Zheng, Christopher A. Loffredo, Ourania Kosti
Publikováno v:
Carcinogenesis. 31:654-659
Given the high incidence of breast cancer and that more than half of cases remain unexplained, the need to identify risk factors for breast cancer remains. Deficiencies in DNA repair capacity have been associated with cancer risk. The mutagen sensiti