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Publikováno v:
Carcinogenesis
Despite advances in molecular characterization of glioblastoma multiforme (GBM), only a handful of predictive biomarkers exist with limited clinical relevance. We aimed to identify differentially expressed genes in tumor samples collected at surgery
Publikováno v:
Carcinogenesis. 38:1021-1028
Metastases in the later stages of hepatocellular carcinoma (HCC) cause the majority of deaths associated with the disease, making early detection crucial to patient survival. Risk models assessing HCC risk in the general population can be used for ri
Autor:
Re’Josef T Jones, DeAdra L Zackery, Bethtrice Elliott, Camille Ragin, Vanessa A Eaton, Fisseha Abebe, Shafiq A. Khan
Publikováno v:
Carcinogenesis. 39(4)
Epidemiological studies show that the incidence and mortality rates of prostate cancer (PCa) are significantly higher in African-American (AA) men when compared with Caucasian (CA) men in the United States. Transforming growth factor β (TGFβ) signa
Autor:
Yohan Bossé, Don D. Sin, Michel Laviolette, Dirkje S. Postma, Peter D. Paré, Massimo Conti, James C. Hogg, Wim Timens, Christian Couture, David C. Nickle, Justin Dang Uy Nguyen, Maxime Lamontagne
Publikováno v:
Carcinogenesis. 35:2653-2659
Recent studies identified three genetic loci reproducibly associated with lung cancer in populations of European ancestry, namely 15q25, 5p15 and 6p21. The goals of this study are first to confirm whether these loci are associated with lung cancer in
Autor:
Yanru Wang, Fang Yang, Hui Xie, Li Quan, Wenwen Zhang, Lulu Cao, Zijia Sun, Hehui Fang, Shui Wang, Yucai Wang, Yan Li, Jan-Åke Gustafsson, Aiyu Zhu, Xiaoxiang Guan, Juan Jin
Publikováno v:
Carcinogenesis. 38(9)
Even with the identical clinicopathological features, the ability for metastasis is vastly different among triple-negative breast cancer (TNBC) patients. Intratumor heterogeneity (ITH), which is common in breast cancer, may be a key mechanism leading
Publikováno v:
Carcinogenesis. 35:1284-1291
Early-stage non-small cell lung cancer (NSCLC) is potentially curative. Nevertheless, many patients will show disease recurrence after curative treatment. The Wnt signaling pathway is a developmental and stem cell pathway that plays an important role
Autor:
Gong Yang, Jing Gao, Wei Zheng, Xiao-Ou Shu, Jie Wu, Honglan Li, Qiuyin Cai, Yong-Bing Xiang, Hui Cai
Publikováno v:
Carcinogenesis. 34:2799-2803
Chronic inflammation has been implicated in the pathogenesis of colorectal cancer. The objective of this study was to evaluate the association of prediagnostic circulating levels of C-reactive protein (CRP), a biomarker of systemic inflammation, with
Autor:
Jocelyn Koo, Sue A. Ingles, Esther M. John, Román Corral, Amit Joshi, Mariana C. Stern, Chelsea Catsburg, Juan Pablo Lewinger
Publikováno v:
Carcinogenesis. 33:2108-2118
Red meat, processed and unprocessed, has been considered a potential prostate cancer (PCA) risk factor; epidemiological evidence, however, is inconclusive. An association between meat intake and PCA may be due to potent chemical carcinogens that are
Autor:
Ju Seog Lee, Christopher G. Wood, Michelle A.T. Hildebrandt, Maosheng Huang, Jie Lin, Yuanqing Ye, Pheroze Tamboli, Weiqi Tan, Xifeng Wu
Publikováno v:
Carcinogenesis. 33:799-803
There are 516 known kinases in the human genome. Because of their important role maintaining proper cellular function, they are often misregulated during tumorigenesis and associated with clinical outcomes in cancer patients, including clear cell ren
Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival
Publikováno v:
Carcinogenesis. 32:1660-1667
Interferons (IFNs) are proteins involved in many functions including antiviral and antimicrobial response, apoptosis, cell cycle control and mediating other cytokines. IFN gamma (IFNG) is a proinflammatory cytokine that modulates many immune-related