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Autor:
Jan Christian Kaiser, Noemi Castelletti, Helmut Küchenhoff, Kyoji Furukawa, Georgios T. Stathopoulos, Cristoforo Simonetto
Publikováno v:
Carcinogenesis 40, 1240-1250 (2019)
KRAS mutations of lung adenocarcinoma (LADC) are associated with smoking but little is known on other exposure-oncogene associations. Hypothesizing that different inciting agents may cause different driver mutations, we aimed to identify distinct mol
Autor:
David M. Levine, Tania Noder, Jakob R. Izbicki, Hauke Lang, Marino Venerito, Hugh Barr, Laura Chegwidden, Timo Hess, Horst Neuhaus, Kirsten B. Moysich, David C. Whiteman, Christine B. Ambrosone, Peter H. Watson, Douglas A. Corley, Harvey A. Risch, Jessica Becker, Rebecca Harrison, Sharon B. Love, James Y. Dai, Arnulf H. Hölscher, Jesper Lagergren, Andrea May, Leslie Bernstein, Anna H. Wu, Thomas Rösch, Geoffrey Liu, Markus M. Nöthen, Paul Moayyedi, Katja Ott, Mario Anders, Michael Vieth, Stuart MacGregor, Johannes Schumacher, Oliver Pech, Qianchuan He, Brigitte Schumacher, Rupert Mayershofer, Lothar Veits, Wong Ho Chow, Matthew F. Buas, Lesley A. Anderson, Puya Gharahkhani, John deCaestecker, Margaret M. Madeleine, Josef Weismüller, Claire Palles, Lynn Onstad, Nicholas J. Shaheen, Susanne Moebus, Christian Gerges, Marilie D. Gammon, Christian Ell, Yogesh K. Vashist, Anne C. Böhmer, Laura J. Hardie, Ines Gockel, Thomas Schmidt, David MacDonald, Stephen Attwood, Shruti G. Dighe, Hendrik Manner, Jianhong Chen, Nicole Kreuser, Dietmar Lorenz, Janusz Jankowski, Hans Prenen, Prasad G. Iyer, Weimin Ye, Michael Knapp, Li Yan, Thomas L. Vaughan, Ian Tomlinson, Claudia Schmidt
Publikováno v:
Carcinogenesis
Dighe, S G, Chen, J, Yan, L, He, Q, Gharahkhani, P, Onstad, L, Levine, D M, Palles, C, Ye, W, Gammon, M D, Iyer, P G, Anderson, L A, Liu, G, Wu, A H, Dai, J Y, Chow, W, Risch, H A, Lagergren, J, Shaheen, N J, Bernstein, L, Corley, D A, Prenen, H, Decaestecker, J, Macdonald, D, Moayyedi, P, Barr, H, Love, S B, Chegwidden, L, Attwood, S, Watson, P, Harrison, R, Ott, K, Moebus, S, Venerito, M, Lang, H, Mayershofer, R, Knapp, M, Veits, L, Gerges, C, Weismüller, J, Gockel, I, Vashist, Y, Nöthen, M M, Izbicki, J R, Manner, H, Neuhaus, H, Rösch, T, Böhmer, A C, Hölscher, A H, Anders, M, Pech, O, Schumacher, B, Schmidt, C, Schmidt, T, Noder, T, Lorenz, D, Vieth, M, May, A, Hess, T, Kreuser, N, Becker, J, Ell, C, Ambrosone, C B, Moysich, K B, Macgregor, S, Tomlinson, I, Whiteman, D C, Jankowski, J, Schumacher, J, Vaughan, T L, Madeleine, M M, Hardie, L J & Buas, M F 2020, ' Germline variation in the insulin-like growth factor pathway and risk of Barrett’s esophagus and esophageal adenocarcinoma ', Carcinogenesis . https://doi.org/10.1093/carcin/bgaa132
Carcinogenesis, 42, 3, pp. 369-377
Carcinogenesis, 42, 369-377
Dighe, S G, Chen, J, Yan, L, He, Q, Gharahkhani, P, Onstad, L, Levine, D M, Palles, C, Ye, W, Gammon, M D, Iyer, P G, Anderson, L A, Liu, G, Wu, A H, Dai, J Y, Chow, W, Risch, H A, Lagergren, J, Shaheen, N J, Bernstein, L, Corley, D A, Prenen, H, Decaestecker, J, Macdonald, D, Moayyedi, P, Barr, H, Love, S B, Chegwidden, L, Attwood, S, Watson, P, Harrison, R, Ott, K, Moebus, S, Venerito, M, Lang, H, Mayershofer, R, Knapp, M, Veits, L, Gerges, C, Weismüller, J, Gockel, I, Vashist, Y, Nöthen, M M, Izbicki, J R, Manner, H, Neuhaus, H, Rösch, T, Böhmer, A C, Hölscher, A H, Anders, M, Pech, O, Schumacher, B, Schmidt, C, Schmidt, T, Noder, T, Lorenz, D, Vieth, M, May, A, Hess, T, Kreuser, N, Becker, J, Ell, C, Ambrosone, C B, Moysich, K B, Macgregor, S, Tomlinson, I, Whiteman, D C, Jankowski, J, Schumacher, J, Vaughan, T L, Madeleine, M M, Hardie, L J & Buas, M F 2020, ' Germline variation in the insulin-like growth factor pathway and risk of Barrett’s esophagus and esophageal adenocarcinoma ', Carcinogenesis . https://doi.org/10.1093/carcin/bgaa132
Carcinogenesis, 42, 3, pp. 369-377
Carcinogenesis, 42, 369-377
Contains fulltext : 235640.pdf (Publisher’s version ) (Closed access) Genome-wide association studies (GWAS) of esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE), have uncovered significant genetic components of risk, but
Autor:
Roy M. Bremnes, Mehrdad Rakaee, Tom Donnem, Sigve Andersen, Erna-Elise Paulsen, Lill-Tove Busund, Thomas Karsten Kilvær
Publikováno v:
Carcinogenesis
The TNM classification is well established as a state-of-the-art prognostic and treatment-decision-making tool for non-small cell lung cancer (NSCLC) patients. However, incorporation of biological data may hone the TNM system. This article focuses on
Autor:
Masayo Motoya, Shigeru Sasaki, Katsuhiko Nosho, Itaru Yamamoto, Hiroyoshi Kurihara, Hideyuki Koide, Yasuhisa Shinomura, Shinichi Kanno, Yasutoshi Kimura, Hiroyuki Maguchi, Keisuke Ishigami, Tadashi Hasegawa, Tokuma Tanuma, Ichiro Takemasa, Kei Mitsuhashi, Hiroshi Nakase, Masahiro Shitani
Publikováno v:
Carcinogenesis. 38:425-431
Pancreatic cancer is a highly aggressive malignancy, with
Autor:
Thomas Longerich, Georg Wiltberger, Ulf P. Neumann, Tom Luedde, Patrick H. Alizai, Marcel Binneboesel, Alexander Koch, Frank Tacke, Thomas Ritz, Christoph Roderburg, Christian Trautwein, Niklas Püthe, Pia Paffenholz, Jakob Nikolas Kather, Frank Bergmann, Sven H. Loosen
Publikováno v:
Carcinogenesis
Carcinogenesis : integrative cancer research 40(8), 947-955 (2019). doi:10.1093/carcin/bgz033
Carcinogenesis, 40(8), 947-955. Oxford University Press
Carcinogenesis : integrative cancer research 40(8), 947-955 (2019). doi:10.1093/carcin/bgz033
Carcinogenesis, 40(8), 947-955. Oxford University Press
Surgical resection represents the only potentially curative therapy for patients with pancreatic adenocarcinoma (PDAC), an aggressive malignancy with a very limited 5-year survival rate. However, even after complete tumor resection, many patients are
Autor:
Renata Talar-Wojnarowska, Claudio Pasquali, Daniele Campa, Maria Rinzivillo, Valbona Liço, Cinzia Cantù, Federico Canzian, Rita T. Lawlor, Thilo Hackert, Gabriele Capurso, Oliver Strobel, Maria Gazouli, Krzysztof Jamroziak, Antonio De Bonis, Ewa Małecka-Panas, Angelo Andriulli, Livia Archibugi, Paola Fogar, Niccola Funel, Anna Caterina Milanetto, Christos Dervenis, William Greenhalf, Francesca Tavano, Stefano Landi, John P. Neoptolemos, Daniela Basso, Ofure Obazee, Luca Landoni, Carlo Federico Zambon, Timothy J. Key
Publikováno v:
Carcinogenesis. 39(7)
Pancreatic neuroendocrine neoplasms (pNEN) account for less than 5% of all pancreatic neoplasms and genetic association studies on susceptibility to the disease are limited. We sought to identify possible overlap of genetic susceptibility loci betwee
Autor:
Raymond F. Burk, Yumie Takata, Qiuyin Cai, Kristina E. Hill, Honglan Li, Yong-Bing Xiang, Wei Zheng, Hui Cai, Xiao-Ou Shu, Jing Gao
Publikováno v:
Carcinogenesis. 39(11)
Selenoprotein P (SELENOP) is a major selenoenzyme in plasma and linked to antioxidant properties and possibly to lung cancer; however, supporting evidence is limited. We investigated the association between pre-diagnostic plasma SELENOP concentration
Autor:
Wei Xu, Lawson Eng, Helen Mackay, Olusola Olusesan Faluyi, Rebecca Wong, Sharon Marsh, Jennifer J. Knox, Daniel J. Renouf, Qin Kuang, Geoffrey Liu, Nanjiao Ying, Sevtap Savas, Gail Darling, Qin Quinn Kong, Abul Kalam Azad, Lorin Dodbiba, Alvina Tse, Dangxiao Cheng, Xin Qiu
Publikováno v:
Carcinogenesis. 36:956-962
Polymorphisms in the vascular endothelial growth factor (VEGF)/angiogenesis pathway have been implicated previously in cancer risk, prognosis and response to therapy including in esophageal adenocarcinoma. Prior esophageal adenocarcinoma studies focu
Autor:
Edna Schechtman, Hedy S. Rennert, Mila Pinchev, Gad Rennert, Ziv Sevilya, Laurence S. Freedman, Yael Leitner-Dagan, Tamar Paz-Elizur, Dalia Elinger, Ran Kremer, Zvi Livneh
Publikováno v:
Carcinogenesis. 35:2763-2770
DNA repair is a major mechanism for minimizing mutations and reducing cancer risk. Here, we present the development of reproducible and specific enzymatic assays for methylpurine DNA glycosylase (MPG) repairing the oxidative lesions 1,N6-ethenoadenin
Autor:
Ajaya Kumar Reka, Theodore J. Standiford, Guoan Chen, Alla Karnovsky, Richard C. Jones, David G. Beer, Venkateshwar G. Keshamouni, Gilbert S. Omenn, Sinae Kim, Ravi Amunugama
Publikováno v:
Carcinogenesis. 35:1292-1300
In cancer cells, the process of epithelial-mesenchymal transition (EMT) confers migratory and invasive capacity, resistance to apoptosis, drug resistance, evasion of host immune surveillance and tumor stem cell traits. Cells undergoing EMT may repres