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Autor:
Koji Ogawa, Toshiya Kamiyama, Hideki Yokoo, Akinobu Taketomi, Moto Fukai, Naoya Sakamoto, Masafumi Ohira
Publikováno v:
Carcinogenesis. 42:794-803
Fatty acid-binding protein 5 (FABP5) is highly expressed in hepatocellular carcinoma (HCC) tissues and is related to HCC progression. In this study, we analyzed the potential of serum FABP5 (sFABP5) as a tumor marker in HCC and its clinical significa
Publikováno v:
Carcinogenesis
Despite advances in molecular characterization of glioblastoma multiforme (GBM), only a handful of predictive biomarkers exist with limited clinical relevance. We aimed to identify differentially expressed genes in tumor samples collected at surgery
Autor:
Aya Naiki-Ito, Satoru Takahashi, Masayuki Komura, Kenta Kachi, Shugo Suzuki, Taku Naiki, Kenju Nakao, Yoichi Matsuo, Akihisa Kato, Hiroyuki Kato, Shingo Inaguma
Publikováno v:
Carcinogenesis
The 5-year survival rate of pancreatic ductal carcinoma (PDAC) patients is
This study describes the chemopreventive effects of luteolin on pancreatic carcinogenesis via STAT3 inactivation caused by DPYD down-regulation, resulting in suppression
This study describes the chemopreventive effects of luteolin on pancreatic carcinogenesis via STAT3 inactivation caused by DPYD down-regulation, resulting in suppression
Autor:
Kang Wang, Yun-Bing Wang, Guo-Chao Zhong, Peng-Fei Yang, Jing-Jing Wu, Fa-Bao Hao, Jie-Jun Hu, Qu-Jin Li
Publikováno v:
Carcinogenesis. 42:724-732
Low-carbohydrate diets have become a popular approach for weight loss in recent years. However, whether low-carbohydrate diets are associated with the risk of pancreatic cancer remains to be elucidated. Hence, we examined the association of low-carbo
Publikováno v:
Carcinogenesis
The neoplastic Hodgkin/Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) depend on chronic activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signalling pathways to maintain survival and prolifer
Publikováno v:
Carcinogenesis
CircRNAs (circular RNAs), recently identified as a critical regulator in tumorigenesis, participate in CRC (colorectal cancer) growth. However, the role of hsa_circRNA_002144 in CRC was poorly understood. Firstly, hsa_circRNA_002144 showed significan
Autor:
Jian Ming Hu, Xin Yuan, Chun Xia Liu, An Zhi Zhang, Man Li, Wei Hua Liang, Yu Fang Xie, Jiang Fen Li, Lan Yang, Li Juan Pang, Chen Hao Jiang, Feng Li, Haijun Zhang, Fan Ping Li
Publikováno v:
Carcinogenesis. 42:537-545
Macrophages are a double-edged sword with potential cancer-promoting and anticancer effects. Controversy remains regarding the effect of macrophages, especially M1 macrophages, on tumor promotion and suppression. We aimed to investigate the role of M
Autor:
Kosaku Mimura, Shotaro Nakajima, Katsuharu Saito, Kouya Shiraishi, Shotaro Fujita, Hirokazu Okayama, Leo Yamada, Hisashi Onozawa, Wataru Sakamoto, Hiroshi Nakano, Hisahito Endo, Hiroyuki Hanayama, Koji Kase, Shinji Ohki, Motonobu Saito, Zenichiro Saze, Tomoyuki Momma, Daisuke Takayanagi, Mai Ashizawa, Takashi Kohno, Koji Kono
Publikováno v:
Carcinogenesis. 42:21-30
AT-rich interactive domain 1A (ARID1A), which is a tumor suppressor gene, is frequently mutated in Epstein-Barr virus-positive gastric cancer [EBV (+) GC]. While most ARID1A mutations in GC are truncating mutations, leading to loss of ARID1A protein
Autor:
Francesc Balaguer, Juan Ruiz-Bañobre, Miren Alustiza Fernández, Miguel Pera, Roshni Roy, Ajay Goel, Rodrigo Jover, Rafael López-López, Oscar Murcia
Publikováno v:
Carcinogenesis
Accumulating evidence supports the fact that the mere presence of mucinous differentiation in colorectal cancer (CRC), rather than its proportion, is a more accurate representative of a particular CRC subtype with distinct clinical and molecular feat
Autor:
Hadar Brand, Keren Bahar-Shany, Tamar Geiger, Yair Pozniak, Jasmine Jacob-Hirsch, Keren Levanon, Yuval Yung, Georgina D. Barnabas, Stav Sapoznik, Ariel Hourvitz
Publikováno v:
Carcinogenesis. 41:1703-1712
The fallopian tube secretory epithelial cells (FTSECs) are the cell-of-origin of most high-grade serous ovarian carcinomas (HGSOC). FTSECs are repeatedly exposed to inflammation induced by follicular fluid (FF) that is released with every ovulation c