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Autor:
Koji Ogawa, Toshiya Kamiyama, Hideki Yokoo, Akinobu Taketomi, Moto Fukai, Naoya Sakamoto, Masafumi Ohira
Publikováno v:
Carcinogenesis. 42:794-803
Fatty acid-binding protein 5 (FABP5) is highly expressed in hepatocellular carcinoma (HCC) tissues and is related to HCC progression. In this study, we analyzed the potential of serum FABP5 (sFABP5) as a tumor marker in HCC and its clinical significa
Publikováno v:
Carcinogenesis
Despite advances in molecular characterization of glioblastoma multiforme (GBM), only a handful of predictive biomarkers exist with limited clinical relevance. We aimed to identify differentially expressed genes in tumor samples collected at surgery
Autor:
Aya Naiki-Ito, Satoru Takahashi, Masayuki Komura, Kenta Kachi, Shugo Suzuki, Taku Naiki, Kenju Nakao, Yoichi Matsuo, Akihisa Kato, Hiroyuki Kato, Shingo Inaguma
Publikováno v:
Carcinogenesis
The 5-year survival rate of pancreatic ductal carcinoma (PDAC) patients is
This study describes the chemopreventive effects of luteolin on pancreatic carcinogenesis via STAT3 inactivation caused by DPYD down-regulation, resulting in suppression
This study describes the chemopreventive effects of luteolin on pancreatic carcinogenesis via STAT3 inactivation caused by DPYD down-regulation, resulting in suppression
Autor:
Francesc Balaguer, Juan Ruiz-Bañobre, Miren Alustiza Fernández, Miguel Pera, Roshni Roy, Ajay Goel, Rodrigo Jover, Rafael López-López, Oscar Murcia
Publikováno v:
Carcinogenesis
Accumulating evidence supports the fact that the mere presence of mucinous differentiation in colorectal cancer (CRC), rather than its proportion, is a more accurate representative of a particular CRC subtype with distinct clinical and molecular feat
Autor:
Keqiu Jiang, Rui Li, Zeli Yin, Qi Wang, Yang Zhou, Chengyong Dong, Rui Sun, Junlin Zhang, Jiaxin Lv, Liming Wang
Publikováno v:
Carcinogenesis. 41:1583-1591
Liver cancer is a major threat to human life and health, and chemotherapy has been the standard non-surgical treatment for liver cancer. However, the emergence of drug resistance of liver cancer cells has hindered the therapeutic effect of chemical d
Publikováno v:
Carcinogenesis. 41:1253-1262
Forkhead box D3 (FOXD3), an important member of the forkhead box transcription factor family, has many biological functions. However, the role and signaling pathways of FOXD3 in colorectal cancer (CRC) are still unclear. We examined FOXD3 expression
Autor:
Jan Christian Kaiser, Noemi Castelletti, Helmut Küchenhoff, Kyoji Furukawa, Georgios T. Stathopoulos, Cristoforo Simonetto
Publikováno v:
Carcinogenesis 40, 1240-1250 (2019)
KRAS mutations of lung adenocarcinoma (LADC) are associated with smoking but little is known on other exposure-oncogene associations. Hypothesizing that different inciting agents may cause different driver mutations, we aimed to identify distinct mol
Autor:
Roy M. Bremnes, Mehrdad Rakaee, Tom Donnem, Sigve Andersen, Erna-Elise Paulsen, Lill-Tove Busund, Thomas Karsten Kilvær
Publikováno v:
Carcinogenesis
The TNM classification is well established as a state-of-the-art prognostic and treatment-decision-making tool for non-small cell lung cancer (NSCLC) patients. However, incorporation of biological data may hone the TNM system. This article focuses on
Publikováno v:
Carcinogenesis. 41(12)
Immune dysfunction plays an important role in tumour development, recurrence, therapeutic responses and overall survival (OS). Multiple myeloma (MM) is a clonal B-cell malignancy which characterized by anti-tumoural immune dysfunction. In this study,
Autor:
Motonobu Saito, Shinji Ohki, Shotaro Fujita, Hirokazu Okayama, Hisahito Endo, Hiroyuki Hanayama, Leo Yamada, Tomoyuki Momma, Kosaku Mimura, Eisei Endo, Katsuharu Saito, Aung Kyi Thar Min, Koji Kase, Tomohiro Kikuchi, Koji Kono, Mai Ashizawa, Wataru Sakamoto, Zenichiro Saze, Daisuke Ujiie
Publikováno v:
Carcinogenesis. 41(5)
Adjuvant chemotherapy is considered for patients with stage II colorectal cancer (CRC) characterized by poor prognostic clinicopathological features; however, current stratification algorithms remain inadequate for identifying high-risk patients. To