Zobrazeno 241 - 250
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Autor:
Chii Ruey Tzeng, Ming Ping Wu, Li Wha Wu, Ming Jer Young, Kuo Feng Huang, Ching Cherng Tzeng, Cheng Yang Chou
Publikováno v:
Carcinogenesis. 29:1115-1123
Thrombospondin (TSP)-1, a potent angiogenesis inhibitor, has been shown to exert different biological functions on various cell types. Here, we investigate the role of TSP-1 in tumor-stroma reaction, which is mainly characterized by fibroblast activa
Autor:
Ann W. Hsing, Philip S. Rosenberg, Yu-Tang Gao, Gabriella Andreotti, Bai He Zhang, Bin Sheng Wang, Stephen J. Chanock, Bingshu E. Chen, Michael F. Leitzmann, Asif Rashid, Shih Chen Chang, Jinbo Chen, Lori C. Sakoda, Tian Quan Han, Ming Chang Shen
Publikováno v:
Carcinogenesis
Biliary tract cancer, encompassing tumors of the gallbladder, extrahepatic bile ducts and ampulla of Vater, is a rare but highly fatal malignancy. Obesity and gallstones, both related to insulin resistance, are linked to an elevated risk of biliary c
Autor:
Sevim Alkaya, Erik Noetzel, Jürgen Veeck, Edgar Dahl, Cordelia Geisler, Arndt Hartmann, Ruth Knüchel
Publikováno v:
Carcinogenesis. 29:991-998
Disruption of the Wnt pathway is thought to be crucial in the development of human cancer. Pathway inhibitory members of the secreted frizzled-related protein (SFRP) family were found to be downregulated due to epigenetic inactivation in various mali
Autor:
Huihua Li, Jin Wei, Nanyan Rao, Kanaga Sabapathy, Wen Feng Li, Zhiming Shao, San San Lum, Hui Wan Chua
Publikováno v:
Carcinogenesis. 29:754-761
Sporadic breast cancer in women
Autor:
Xuemei Ji, Kristina R. Dahlstrom, Ana C Candia Solari Neumann, Guojun Li, Qingyi Wei, Erich M. Sturgis, Karen Adler-Storthz, John T. Schiller
Publikováno v:
Carcinogenesis. 29:875-879
The tumor suppressor p53 protein can be bound, degraded and inactivated by the human papillomavirus (HPV) E6 oncoprotein. The p53 protein's susceptibility to this oncoprotein may be influenced by the p53 codon 72 polymorphism, but the role of such a
Publikováno v:
Carcinogenesis. 29:363-370
The tissue concentrations of the female sex hormone 17beta-estradiol (E2) and its reactive catechol metabolites such as 4-hydroxyestradiol (4-HO-E2) play important roles in hormonal carcinogenesis. They are influenced by the activity of local enzymes
Autor:
Hye-Kyung Na, Na-Young Song, Young-Joon Surh, Ha-Na Kim, Do-Hee Kim, Eun-Hee Kim, Sin-Aye Park
Publikováno v:
Carcinogenesis. 29:688-695
Recent studies suggest that inflammation is causally linked to carcinogenesis. Cyclooxygenase-2 (COX-2), a rate-limiting enzyme in the biosynthesis of prostaglandins, is inappropriately expressed in various cancers and hence recognized as one of the
Autor:
Meng Tang, Jia-Sheng Wang, Haitao Luo, Tianren Huang, Weimin Gao, Lili Tang, Jiahua Yu, Li Xu, Stephen B. Cox, Lisheng Zhang
Publikováno v:
Carcinogenesis. 29:411-417
To evaluate the efficacy of green tea polyphenols (GTPs) in modulating aflatoxin B(1) (AFB(1)) biomarkers, a total of 352 serum samples and 352 urine samples collected from a 3 month chemoprevention trial with 500 mg GTPs, 1000 mg GTPs and a placebo
Publikováno v:
Carcinogenesis. 29:390-397
Nitric oxide-donating aspirin (NO-ASA) is a promising agent for the control of cancer, whose mechanism of action remains unclear. NF-kappaB is an important signaling molecule in the pathogenesis of cancer. We studied in several human colon (HT-29, HC
Autor:
Takeshi Suzuki, Keitaro Matsuo, Akio Hiraki, Kaoru Hirose, Miki Watanabe, Hiroji Iwata, Takakazu Kawase, Toshinari Yamashita, Kazuo Tajima
Publikováno v:
Carcinogenesis. 29:356-362
Environmental exposures and/or genetic background in Japanese population, which might contribute to the relatively low breast cancer incidence rates in Japan, have not been clarified in detail. Folate plays an essential role in DNA methylation and sy