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Publikováno v:
Carcinogenesis. 36:676-684
We investigated mechanisms of pancreatic cancer metastasis and defined the biological role of miR-29c in pancreatic cancer metastasis. After two rounds of cell selection in vivo, pancreatic cancer cells with various metastatic potentials derived from
Autor:
Kaixuan Lin, Guangzhou Gao, Shouzhi Ma, Yulin Sun, Fang Liu, Xiu-Hua Qu, Xiao Yang, Jianqiang Cai, Xiaohong Qian, Lidong He, Youliang Wang, Xiaohang Zhao, Yangjun Zhang
Publikováno v:
Carcinogenesis
To date, the useful markers of hepatocellular carcinoma (HCC) remains incompletely developed. Here, we show that annexin A2 complement alpha-fetoprotein (AFP), a widely used liver cancer marker, in the serologically surveillance and early detection o
Autor:
Tomoo Kitajima, Takehiro Mishima, Amane Kitasato, Taiichiro Kosaka, Takashi Kanematsu, Noritsugu Tsuneoka, Yoshitsugu Tajima, Tamotsu Kuroki, Tomohiko Adachi
Publikováno v:
Carcinogenesis. 30:1763-1767
The present study was designed to investigate whether an inducible nitric oxide synthase (iNOS)-specific inhibitor, ONO-1714 [(1S, 5S, 6R, 7R)-7-chloro-3-imino-5-methyl-2-azabicyclo[4.1.0] heptane], could prevent inflammation-associated biliary carci
Autor:
Jerrold M. Ward, Keiichirou Morimura, Yatrik M. Shah, Insook Kim, Frank J. Gonzalez, Qian Yang
Publikováno v:
Carcinogenesis. 28:940-946
The farnesoid X receptor (FXR) controls the synthesis and transport of bile acids. Mice lacking expression of FXR, designated Fxr-null, have elevated levels of serum and hepatic bile acids and an increase in bile acid pool size. Surprisingly, at 12 m
Autor:
Tomoo Kitajima, Noritsugu Tsuneoka, Shinya Onizuka, Takashi Kanematsu, Tamotsu Kuroki, Amane Kitazato, Yoshitsugu Tajima, Kenzo Fukuda
Publikováno v:
Carcinogenesis. 26:465-469
The present study was designed to evaluate whether etodolac, a cyclooxgenase-2 (COX-2)-specific inhibitor, could prevent chemically induced biliary carcinogenesis in bilioenterostomized hamsters. Syrian golden hamsters were subjected to choledochojej
Publikováno v:
Carcinogenesis. 25:1027-1031
Increased oxidative stress and lipid peroxidation (LPO) are implicated in multistage carcinogenesis. Recent studies have shown that LPO-derived reactive hydroxyalkenals can form promutagenic exocyclic etheno-DNA adducts in vivo. Such DNA damage was f
Autor:
Marine Gross-Goupil, Patrick Pham, Raphaël Saffroy, Alain Barrier, Franck Chiappini, Laurent Castera, Didier Samuel, Brigitte Debuire, Daniel Azoulay, Antoinette Lemoine
Publikováno v:
Carcinogenesis. 25:1443-1448
Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation and in the production of dTMP for DNA synthesis. Different polymorphisms have been described for
Autor:
Arne K. Sandvik, Tom C. Martinsen, Gunnar Qvigstad, Rolf Håkanson, Reidar Fossmark, Helge L. Waldum, Shiro Kawase, Sverre H. Torp
Publikováno v:
Carcinogenesis. 24:1887-1896
In our inbred strain of cotton rats (Sigmodon hispidus) 50% of the females develop spontaneous ECL cell-derived tumors in the acid-producing part of the stomach due to hypergastrinemia secondary to gastric hypoacidity. Although the mechanism behind t
Autor:
Young-In Kim, Kyoung-Jin Sohn, Alan Medline, Monica Choi, Stephen W. Hwang, Colin McKerlie, Joanne Kotsopoulos, Rochelle Martin, Richard Renlund
Publikováno v:
Carcinogenesis. 24:937-944
Epidemiologic studies have suggested that dietary folate intake is inversely related to breast cancer risk. However, epidemiologic evidence has not been consistent nor has it provided unequivocal support for this purported inverse relationship. This
Autor:
Takashi Kanematsu, Kenzou Fukuda, Yoshitsugu Tajima, Tomoo Kitajima, Sumihiro Matsuzaki, Tamotsu Kuroki
Publikováno v:
Carcinogenesis. 24:133-137
Biliary carcinomas can occur as a delayed complication of bilioenterostomy. The aim of this study was to determine whether bilioenterostomy influences biliary carcinogenesis in hamsters. Syrian hamsters were subjected to three different surgical proc