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Publikováno v:
Carcinogenesis. 41:909-917
Imbalance of the gut microbial community promotes inflammation and colorectal cancer (CRC). Previously, we demonstrated that freeze-dried Parabacteroides distasonis (Pd) suppressed obesity-driven colorectal tumorigenesis in mice. Here, we investigate
Autor:
Bruna Girardi, Maria Pricci, Alfredo Di Leo, Giuseppe Losurdo, Floriana Giorgio, Enzo Ierardi, Andrea Iannone, Michele Barone, Mariabeatrice Principi
Publikováno v:
Carcinogenesis. 39:1274-1282
On the basis of preliminary in vitro experience, we assessed whether an enriched nutritional formulation with estrogen receptor (ER)-beta agonist and anti-inflammatory properties may prevent inflammation-associated colorectal cancer (CRC) in an anima
Autor:
Melody Baddoo, Chloe Cable, Hani Nakhoul, Suzana D. Savkovic, Erik K. Flemington, Susan E. Crawford, Sandra Heller, Harrison M. Penrose
Publikováno v:
Carcinogenesis. 38:302-311
Obesity, an immense epidemic affecting approximately half a billion adults, has doubled in prevalence in the last several decades. Epidemiological data support that obesity, due to intake of a high-fat, western diet, increases the risk of colon cance
Publikováno v:
Carcinogenesis. 36:478-486
Microsomal PGE2 synthase-1 (mPGES-1), the terminal enzyme in the formation of inducible PGE2, represents a potential target for cancer chemoprevention. We have previously shown that genetic abrogation of mPGES-1 significantly suppresses tumorigenesis
Autor:
Yubao Jiang, Karl J. Smalley, Louise Y.Y. Fong, Kay Huebner, Paolo Fadda, Hansjuerg Alder, Hatice Gulcin Ozer, Hongping Chen, Carlo M. Croce, John L. Farber, Cristian Taccioli
Publikováno v:
Carcinogenesis. 33:1736-1744
Zinc deficiency (ZD) increases the risk of esophageal squamous cell carcinoma (ESCC). In a rat model, chronic ZD induces an inflammatory gene signature that fuels ESCC development. microRNAs regulate gene expression and are aberrantly expressed in ca
Publikováno v:
Carcinogenesis
Prostate cancer incidence and mortality are high in the Western world and high ω-6/ω-3 PUFA in the Western diet may be a contributing factor. We investigated whether changing from a diet that approximates ω-6 fat content of the Western diet to a h
Autor:
Siphora Dien, Tohru Kataoka, Hironori Edamatsu, Nobuyuki Takenaka, Kazumi Norose, Riko Kitazawa, Chikako Nishigori, Masahiro Oka, Masanobu Sakaguchi, Makoto Kunisada, Lizhi Hu
Publikováno v:
Carcinogenesis. 31:1897-1902
Phospholipase C (PLC) ε is a phosphoinositide-specific PLC regulated by small guanosine triphosphatases including Ras and Rap. Our previous studies revealed that PLCε gene-knockout (PLCε(-/-)) mice exhibit marked resistance to tumor formation in t
Autor:
Linda Zimmer-Nechemias, Xueheng Zhao, Carrie A. Belles, Mi-Ok Kim, Kenneth D.R. Setchell, Nadine M Brown, Stephanie L. Lindley, David P. Witte
Publikováno v:
Carcinogenesis. 31:886-893
We describe for the first time the chemopreventive effects of S-(-)equol and R-(+)equol, diastereoisomers with contrasting affinities for estrogen receptors (ERs). S-(-)equol, a ligand for ERbeta, is an intestinally derived metabolite formed by many
Publikováno v:
Carcinogenesis. 29:390-397
Nitric oxide-donating aspirin (NO-ASA) is a promising agent for the control of cancer, whose mechanism of action remains unclear. NF-kappaB is an important signaling molecule in the pathogenesis of cancer. We studied in several human colon (HT-29, HC
Autor:
Timothy M. Willson, Michael G. Borland, Jeffrey M. Peters, Holly E. Hollingshead, Frank J. Gonzalez, Andrew N. Billin
Publikováno v:
Carcinogenesis. 29:169-176
Cyclooxygenase (COX) 2-derived prostaglandin E(2) (PGE(2)) promotes colorectal carcinoma growth and invasion, and inhibition of COX2 by non-steroidal anti-inflammatory drugs is known to inhibit these processes. There is controversy regarding the effe