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Autor:
Susan D. Hester, Elias T. Gaillard, Tanya Moore, Michael H. George, Charles E. Wood, William O. Ward, Carlin Okerberg, Anthony B. DeAngelo, Anna Fisher, Brian N. Chorley, April D. Lake, Hongzu Ren, Gleta Carswell, Beena Vallanat
Publikováno v:
Carcinogenesis. 36:782-791
Environmental exposures occurring early in life may have an important influence on cancer risk later in life. Here, we investigated carryover effects of dichloroacetic acid (DCA), a small molecule analog of pyruvate with metabolic programming propert
Autor:
Brian E. Hsu, Kevin L. Bennewith, Gerald Krystal, Aalim M. Weljie, Victor W. Ho, Ngoc-Ha Thi Dang, Emma S. Tomlinson Guns, Melisa J. Hamilton, Ismael Samudio, Hans Adomat
Publikováno v:
Carcinogenesis. 35:2291-2299
We recently demonstrated that both murine and human carcinomas grow significantly slower in mice on low carbohydrate (CHO), high protein diets than on isocaloric Western diets and that a further reduction in tumor growth rates occur when the low CHO
Autor:
Tanios Bekaii-Saab, Samuel K. Kulp, I. Lu Lai, Xiaokui Mo, Ching-Shih Chen, Lawrence A. Shirley, Po-Ting Lai, Mark Bloomston, Chun Sheng Fang, Chih-Chien Chou, Ribai Yan
Publikováno v:
Carcinogenesis. 35:2203-2213
Gemcitabine resistance remains a significant clinical challenge. Here, we used a novel glucose transporter (Glut) inhibitor, CG-5, as a proof-of-concept compound to investigate the therapeutic utility of targeting the Warburg effect to overcome gemci
Autor:
Satoko Matsumura, Anjana Saxena, Eric D. Schalfer, Susan K. Logan, Yingjie Wu, Tunde Akinyeke, Wenbo Yan, Xinying Wang, Xin Li
Publikováno v:
Carcinogenesis. 34:2823-2832
Prostate cancer (PCa) is the second leading cause of cancer-related death in American men and many PCa patients develop skeletal metastasis. Current treatment modalities for metastatic PCa are mostly palliative with poor prognosis. Epidemiological st
Autor:
Jörg Fahrer, Bernd Kaina
Publikováno v:
Carcinogenesis. 34:2435-2442
Colorectal cancer (CRC) is among the leading causes of cancer death worldwide, involving multiple dietary and non-dietary risk factors. A growing body of evidence suggests that N-nitroso compounds (NOC) play a pivotal role in the etiology of CRC. NOC
Autor:
Laurent Dubuquoy, Antoine Cortot, Benjamin Bertin, Christel Rousseaux, Denis Chatelain, Caroline Dubuquoy, Pierre Desreumaux, Mathurin Fumery, Audrey Langlois, Olivier Romano, David Buob, Noura El-Jamal, Jean-Frederic Colombel
Publikováno v:
Carcinogenesis
Epidemiological evidences suggested that 5-aminosalicylic acid (5-ASA) therapy may prevent the development of colorectal cancer in inflammatory bowel disease patients. Our aim is to investigate whether peroxisome proliferator-activated receptor-γ (P
Autor:
Niranjan Awasthi, Margaret A. Schwarz, Changhua Zhang, Noelle S. Williams, Stefan Hinz, Anna M. Schwarz, Chang-Guang Wang, Roderich E. Schwarz
Publikováno v:
Carcinogenesis. 34:2361-2369
Gemcitabine has limited clinical benefits in pancreatic ductal adenocarcinoma. The solvent-based traditional taxanes docetaxel and paclitaxel have not shown clinical results superior to gemcitabine. Nab-paclitaxel, a water-soluble albumin-bound pacli
Autor:
Ninche Alston, Chi Chun Wong, Gerardo G. Mackenzie, Liqun Huang, Nengtai Ouyang, Ioannis Papayannis, Ting Nie, Basil Rigas, Dingying Zhou
Publikováno v:
Carcinogenesis. 34:943-951
We have synthesized a novel derivative of indomethacin, phospho-tyrosol-indomethacin (PTI; MPI-621), and evaluated its anticancer efficacy in vitro and in vivo. PTI inhibited the growth of human colon, breast and lung cancer cell lines 6–30-fold mo
Autor:
Yatrik M. Shah, Xiang Xue
Publikováno v:
Carcinogenesis. 34:163-169
Cyclooxygenase 2 (COX2) is overexpressed in 80% of colon adenocarcinomas. However, the mechanism leading to aberrant COX2 expression in tumors is unclear. Intestinal epithelium-specific disruption of the von Hippel-Lindau tumor suppressor protein (VH
Autor:
Daniel R. Doerge, William G. Helferich, James A. Hartman, Mengyuan Du, Xujuan Yang, Young H. Ju, Paul S. Cooke
Publikováno v:
Carcinogenesis. 33:895-901
The present study examined the effect of dietary genistein, a soy isoflavone, on breast cancer patients who take tamoxifen, an antiestrogen treatment, using a preclinical model. The interaction of various doses of genistein with tamoxifen on the grow