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Autor:
Yi Jun Zhu, Gongshe Yang, Jayme Borensztajn, Yuzhi Jia, Yiwei Tony Zhu, Jiansheng Huang, Liang Bai, M. Sambasiva Rao, Janardan K. Reddy, Navin Viswakarma, Kojiro Matsumoto
Publikováno v:
Carcinogenesis
Nuclear receptor coactivator [peroxisome proliferator-activated receptor-binding protein (PBP)/mediator subunit 1 (MED1)] is a critical component of the mediator transcription complex. Disruption of this gene in the mouse results in embryonic lethali
lipoic acid promotes the growth of rat hepatic pre-neoplastic lesions in the choline-deficient model
Autor:
Monica Pibiri, Giovanna M. Ledda-Columbano, Pia Sulas, Andrea Perra, Gabriella Simbula, Amedeo Columbano
Publikováno v:
Carcinogenesis. 29:161-168
alpha-lipoic acid (alpha-LA) is an antioxidant used in a number of conditions related to liver diseases. Herein, we investigated the effect of alpha-LA on the development of rat pre-neoplastic lesions generated by a model of hepatocarcinogenesis, whi
Autor:
Thomas Prates Ong, Fernando Salvador Moreno, Aline de Conti, Maria Lúcia Zaidan Dagli, Renato Heidor
Publikováno v:
Carcinogenesis. 27:1194-1203
Chemopreventive activities of farnesol (FOH) and geraniol (GOH) were evaluated during the initial phases of hepatocarcinogenesis. Rats received during eight consecutive weeks 25 mg/100 g body weight FOH (FOH group) or GOH (GOH group), or only corn oi
Autor:
Lennart Eriksson, Christina Nyström, Erik Huusfeldt Larsen, Linda Björkhem-Bergman, Mikael Björnstedt, Arrigo Capitanio, Ulla-Britta Torndal, Servet Eken
Publikováno v:
Carcinogenesis. 26:125-131
Previous studies in animals and humans have shown that selenium compounds can prevent cancer development. In this work we studied the tumor preventive effect of selenium supplementation, administrated as selenite, in the initiation, promotion and pro
Autor:
Costanza Cossu, Francesca Molotzu, Giovanna M. Ledda-Columbano, Amedeo Columbano, L. Sanna, Andrea Perra, Monica Pibiri, Gabriella Simbula
Publikováno v:
Carcinogenesis. 25:2061-2066
Retinoids have been shown to exert an anticarcinogenic effect through suppression of the cell cycle, induction of apoptosis and/or differentiation. In rat liver, in particular, retinoic acid has been shown to inhibit regeneration after partial hepate
Publikováno v:
Carcinogenesis. 22:1843-1851
Rodents exposed to peroxisome proliferator xenobiotics respond with marked increases in hepatocellular replication and growth that results in tumor formation. Recently, tumor necrosis factor-alpha (TNFalpha) was proposed as the central mediator of th
Publikováno v:
Carcinogenesis. 22:1601-1605
Polychlorinated biphenyls (PCBs) are among the most prominent persistent environmental pollutants exhibiting neurotoxic, teratogenic and tumour-promoting effects in experimental animals. 'Dioxin-like' properties have been assigned to a number of PCBs
Publikováno v:
Carcinogenesis. 22:1213-1219
Chronic and excessive ethanol intake decreases hepatic retinoic acid (RA) concentrations, which may play a critical role in ethanol-induced hyperproliferation in hepatocytes. The present study was conducted to determine whether RA supplementation in
Publikováno v:
Carcinogenesis. 21:2159-2165
Induction of liver cancer by peroxisome proliferators such as nafenopin is frequently associated with increased liver growth, increased DNA synthesis and suppression of apoptosis. The cytokine, tumour necrosis factor alpha (TNF alpha), and non-parenc
Publikováno v:
Carcinogenesis. 21:823-826
Peroxisome proliferators increase hepatocyte proliferation and cause liver tumors in rodents, yet the mechanism of action is not understood. Based on studies with null mice it is known that peroxisome proliferator-activated receptor-alpha (PPARalpha)