Zobrazeno 1 - 10
of 6 190
pro vyhledávání: '"0301 basic medicine"'
Autor:
Mirjam de With, Daan P. Hurkmans, Esther Oomen-de Hoop, Ayoub Lalouti, Sander Bins, Samira El Bouazzaoui, Mandy van Brakel, Reno Debets, Joachim G. J. V. Aerts, Ron H. N. van Schaik, Ron H. J. Mathijssen, Astrid A. M. van der Veldt
Publikováno v:
Cancers
Volume 13
Issue 6
Cancers, Vol 13, Iss 1370, p 1370 (2021)
Cancers, 13(6):1370, 1-13. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 13
Issue 6
Cancers, Vol 13, Iss 1370, p 1370 (2021)
Cancers, 13(6):1370, 1-13. Multidisciplinary Digital Publishing Institute (MDPI)
A substantial number of melanoma patients do not benefit from therapy with anti-PD-1. Therefore, we investigated the predictive value of single nucleotide polymorphisms (SNPs) in genes related to the PD-1 axis in patients with metastatic melanoma. Fr
Autor:
Yann Seimbille, Sofia Koustoulidou, Simone U. Dalm, Shweta Mahajan, Marion de Jong, Reno Debets, Mark W. H. Hoorens
Publikováno v:
Cancers, Vol 13, Iss 1100, p 1100 (2021)
Cancers
Cancers, 13(5):1100, 1-19. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers
Cancers, 13(5):1100, 1-19. Multidisciplinary Digital Publishing Institute (MDPI)
Simple Summary The tumour microenvironment contains a unique population of cells, of complex origin and diverse functionality, known as Cancer associated fibroblasts (CAFs). In recent years there has been a growing interest in targeting CAFs to aid c
Autor:
Alexander L. Vahrmeijer, Stijn Keereweer, Judith V.M.G. Bovée, Cornelis F. M. Sier, S. E. Bosma, A Naweed Shifai, Pieter B A A van Driel, Peter J. K. Kuppen, Zeger Rijs, Michiel A. J. van de Sande
Publikováno v:
Cancers, Vol 13, Iss 557, p 557 (2021)
Cancers
Cancers, 13(3):557, 1-29. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 13(3). MDPI
Cancers
Cancers, 13(3):557, 1-29. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 13(3). MDPI
Simple SummaryNear-infrared imaging of tumors during surgery facilitates the oncologic surgeon to distinguish malignant from healthy tissue. The technique is based on fluorescent tracers binding to tumor biomarkers on malignant cells. Currently, ther
Autor:
Giorgia Zambito, Paolo A. Netti, Joost C. Haeck, Enza Torino, Martine L.M. Lamfers, Laura Mezzanotte, Angela Costagliola di Polidoro
Publikováno v:
Cancers, Vol 13, Iss 503, p 503 (2021)
Cancers
Volume 13
Issue 3
Cancers, 13(3):503, 1-21. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers
Volume 13
Issue 3
Cancers, 13(3):503, 1-21. Multidisciplinary Digital Publishing Institute (MDPI)
Simple Summary Glioblastoma multiforme is the most aggressive malignant brain tumor with poor patient prognosis. The presence of the blood-brain barrier and the complex tumor microenvironment impair the efficient accumulation of drugs and contrast ag
Autor:
Thomas Wurdinger, Thang V. Pham, Ilias Glogovitis, Giulia Mantini, Geert Kazemier, Connie R. Jimenez, Tessa Y S Le Large, Elisa Giovannetti, Rosita Paleckyte, Sjors G J G In 't Veld, Laura L. Meijer, Adam E Frampton, M. Capula, Danijela Koppers-Lalic, Sander R. Piersma, Luca Morelli
Publikováno v:
Cancers
Volume 13
Issue 1
Cancers, Vol 13, Iss 66, p 66 (2021)
Cancers, 13(1):66, 1-20. Multidisciplinary Digital Publishing Institute (MDPI)
Mantini, G, Meijer, L L, Glogovitis, I, in ‘t Veld, S G J G, Paleckyte, R, Capula, M, le Large, T Y S, Morelli, L, Pham, T V, Piersma, S R, Frampton, A E, Jimenez, C R, Kazemier, G, Koppers-Lalic, D, Wurdinger, T & Giovannetti, E 2021, ' Omics analysis of educated platelets in cancer and benign disease of the pancreas ', Cancers, vol. 13, no. 1, 66, pp. 1-20 . https://doi.org/10.3390/cancers13010066
Volume 13
Issue 1
Cancers, Vol 13, Iss 66, p 66 (2021)
Cancers, 13(1):66, 1-20. Multidisciplinary Digital Publishing Institute (MDPI)
Mantini, G, Meijer, L L, Glogovitis, I, in ‘t Veld, S G J G, Paleckyte, R, Capula, M, le Large, T Y S, Morelli, L, Pham, T V, Piersma, S R, Frampton, A E, Jimenez, C R, Kazemier, G, Koppers-Lalic, D, Wurdinger, T & Giovannetti, E 2021, ' Omics analysis of educated platelets in cancer and benign disease of the pancreas ', Cancers, vol. 13, no. 1, 66, pp. 1-20 . https://doi.org/10.3390/cancers13010066
Pancreatic ductal adenocarcinoma (PDAC) is traditionally associated with thrombocytosis/hypercoagulation and novel insights on platelet-PDAC &ldquo
dangerous liaisons&rdquo
are warranted. Here we performed an integrative omics study investi
dangerous liaisons&rdquo
are warranted. Here we performed an integrative omics study investi
Autor:
Marcelo Correia, Ana Rita Ferreira, Valdemar Máximo, Isabel Valença, Daniela Ribeiro, Hans R. Waterham, Carlo W.T. van Roermund, Markus Islinger, Sandra Kühl
Publikováno v:
Cancers
Volume 12
Issue 11
Cancers, 12(11):3152, 1-15. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, Vol 12, Iss 3152, p 3152 (2020)
Volume 12
Issue 11
Cancers, 12(11):3152, 1-15. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, Vol 12, Iss 3152, p 3152 (2020)
Reprogramming of lipid metabolism directly contributes to malignant transformation and progression. The increased uptake of circulating lipids, the transfer of fatty acids from stromal adipocytes to cancer cells, the de novo fatty acid synthesis, and
Autor:
T. Jeroen N. Hiltermann, Pei Meng, Jiacong Wei, Martijn Terpstra, Ali Saber, Klaas Kok, Wim Timens, Ed Schuuring, Jantine Sietzema, Anna A. Rybczynska, Anke van den Berg, Anthonie J. van der Wekken, Harry J.M. Groen
Publikováno v:
Cancers, 12(10):2843, 1-17. MDPI AG
Cancers
Cancers, Vol 12, Iss 2843, p 2843 (2020)
Volume 12
Issue 10
Cancers
Cancers, Vol 12, Iss 2843, p 2843 (2020)
Volume 12
Issue 10
The number of genomic aberrations known to be relevant in making therapeutic decisions for non-small cell lung cancer patients has increased in the past decade. Multiple molecular tests are required to reliably establish the presence of these aberrat
Autor:
Alexander A. Henneman, Marloes Zoetemelk, Connie R. Jimenez, Richard R. de Haas, Judy R. van Beijnum, Louise C. Reckman, Patrycja Nowak-Sliwinska, Tse J. Wong, Arjan W. Griffioen, Olivier Dormond, Sander R. Piersma, Andrea Weiss, Axel Bex, Robert H. Berndsen
Publikováno v:
Cancers, Vol. 12, No 9 (2020) P. 2697
Cancers
Volume 12
Issue 9
van Beijnum, J R, Weiss, A, Berndsen, R H, Wong, T J, Reckman, L C, Piersma, S R, Zoetemelk, M, de Haas, R, Dormond, O, Bex, A, Henneman, A A, Jimenez, C R, Griffioen, A W & Nowak-Sliwinska, P 2020, ' Integrating phenotypic search and phosphoproteomic profiling of active kinases for optimization of drug mixtures for rcc treatment ', Cancers, vol. 12, no. 9, pp. 1-19 . https://doi.org/10.3390/cancers12092697
Cancers, 12(9), 1-19. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, vol. 12, no. 9, pp. E2697
Cancers, Vol 12, Iss 2697, p 2697 (2020)
Cancers
Volume 12
Issue 9
van Beijnum, J R, Weiss, A, Berndsen, R H, Wong, T J, Reckman, L C, Piersma, S R, Zoetemelk, M, de Haas, R, Dormond, O, Bex, A, Henneman, A A, Jimenez, C R, Griffioen, A W & Nowak-Sliwinska, P 2020, ' Integrating phenotypic search and phosphoproteomic profiling of active kinases for optimization of drug mixtures for rcc treatment ', Cancers, vol. 12, no. 9, pp. 1-19 . https://doi.org/10.3390/cancers12092697
Cancers, 12(9), 1-19. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, vol. 12, no. 9, pp. E2697
Cancers, Vol 12, Iss 2697, p 2697 (2020)
Combined application of multiple therapeutic agents presents the possibility of enhanced efficacy and reduced development of resistance. Definition of the most appropriate combination for any given disease phenotype is challenged by the vast number o
Autor:
Hala El-Said, Marwa Helal, Ashraf Elfert, Israa T. Ismail, Oliver Fiehn, Ibrahim Abdelkader Salama
Publikováno v:
Cancers, Vol 13, Iss 88, p 88 (2021)
Cancers, vol 13, iss 1
Cancers
Volume 13
Issue 1
Cancers, vol 13, iss 1
Cancers
Volume 13
Issue 1
Hepatocellular carcinoma (HCC) is a worldwide health problem. HCC patients show a 50% mortality within two years of diagnosis. To better understand the molecular pathogenesis at the level of lipid metabolism, untargeted UPLC MS&mdash
QTOF lipido
QTOF lipido
Autor:
Geoffrey A. Wood, Rokshana Stephny Geread, Abishika Sivanandarajah, Hala Faragalla, Dimitrios Androutsos, April Khademi, Emily Brouwer
Publikováno v:
Cancers, Vol 13, Iss 11, p 11 (2021)
Cancers
Volume 13
Issue 1
Cancers
Volume 13
Issue 1
In this work, a novel proliferation index (PI) calculator for Ki67 images called piNET is proposed. It is successfully tested on four datasets, from three scanners comprised of patches, tissue microarrays (TMAs) and whole slide images (WSI), represen