Zobrazeno 1 - 10
of 209
pro vyhledávání: ''
Autor:
Yan Liu, Lijun Yang, Ya-Nan Hao, Jianfeng Liu, Xuan Sun, Jinjian Liu, Cui-Cui Zhao, Hong Liu, Chuan-Gui Zhang, Guowei Feng, Qingxiang Guo
Publikováno v:
Cancer Science. 113:733-743
Breast cancer is the leading cause of cancer death among women and almost all of the breast cancer-caused mortality is related to metastasis. It has been reported that glucocorticoid facilitates the metastasis of breast cancer in mice, and mifepristo
Autor:
Lorena Lobo de Figueiredo-Pontes, Hisashi Takei, Ann Mullally, Yuta Mishima, Keli Lima, Ikei S. Kobayashi, Adriana Queiroz Arantes Rocha, Thiago Mantello Bianco, Susumu Kobayashi, João Agostinho Machado-Neto, Cristina Tavares Leal, Robert S. Welner, Juan L Coelho-Silva
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Several lines of research suggest that BCL-XL-mediated anti-apoptotic effects may contribute to pathogenesis of myeloproliferative neoplasms driven by JAK2V617F and serve as therapeutic target. Here, we used a knock-in JAK2V617F mouse model and confi
Autor:
Takashi Fujii, Daisuke Kawauchi, Eita Uchida, Atsuo Yoshino, Yoshitaka Narita, Nobuyoshi Sasaki, Kojiro Wada, Tatsuya Kobayashi, Masamichi Takahashi, Koichi Ichimura, Arata Tomiyama, Kaishi Satomi, Shun Yamamuro, Akihide Kondo, Tomoyuki Nakano
Publikováno v:
Cancer Science
Glioblastomas (GBM) often acquire resistance against temozolomide (TMZ) after continuous treatment and recur as TMZ‐resistant GBM (TMZ‐R‐GBM). Lomustine (CCNU) and nimustine (ACNU), which were previously used as standard therapeutic agents agai
Autor:
Xin Li, Ting Yuan, Rui Sun, Xia Xiong, Yunxiong Wei, Hairong Lyu, Xin Jin, Ming-Feng Zhao, Wenyi Lu, Xiaoyuan He, Tongtong Sun
Publikováno v:
Cancer Science
Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) are usually associated with poor outcomes, especially in high‐risk AML/MDS. Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is the only curative option for patients su
Autor:
Takayuki Yoshino, Hiroya Taniguchi, Ichiro Takemasa, Saori Mishima, Hiroki Yukami, Daisuke Kotani, Kentaro Sawada, Takeharu Yamanaka, Yoshiaki Nakamura, Hiromichi Ebi, Takeshi Kato, Masaki Mori, Hiromichi Shirasu, Alexey Aleshin, Paul Billings, Eiji Oki, Matthew Rabinowitz
Publikováno v:
Cancer Science
Adjuvant chemotherapy has reduced the risk of tumor recurrence and improved survival in patients with resected colorectal cancer. Potential utility of circulating tumor DNA (ctDNA) prior to and post surgery has been reported across various solid tumo
Autor:
Yasue Kimura, Eiji Oki, Yoshiaki Fujimoto, Masahito Kotaka, Koji Ando, Hiroyuki Kitao, Yuji Miyamoto, Masaki Mori, Ryota Nakanishi, Shichao Qiu, Yoshihiko Maehara, Mototsugu Shimokawa, Akitaka Makiyama
Publikováno v:
Cancer Science
Trifluridine/tipiracil (FTD/TPI) is an orally administrated anticancer drug with efficacy validated for patients with metastatic colorectal cancer (mCRC) or gastric cancer. FTD, a key component of FTD/TPI, exerts antitumor effects via its incorporati
Autor:
Yusuke Okuma, Yuki Nakagawa, Kazuo Kasahara, Makoto Nishio, Naoko Sueoka-Aragane, Satoshi Watanabe, Haruhiro Saito, Koichi Goto, Kenichi Chikamori, Tomohisa Kawakami
Publikováno v:
Cancer Science
IMpower132 explored the safety and efficacy of atezolizumab plus pemetrexed and platinum‐based chemotherapy as first‐line treatment for advanced non‐small‐cell lung cancer (NSCLC). Key eligibility criteria for the phase 3, open‐label, IMpow
Autor:
Hiroaki Matsumoto, Hideyasu Matsuyama, Yukimi Sakoda, Yoji Nagashima, Takahiro Sasaki, Koji Tamada, Shunsuke Goto, Jun‐ich Mori, Keishi Adachi
Publikováno v:
Cancer Science
Chimeric antigen receptor (CAR)‐T cell therapy has shown salient efficacy in cancer immunotherapy, particularly in the treatment of B cell malignancies. However, the efficacy of CAR‐T for solid tumors remains inadequate. In this study, we display
Autor:
Komoto, Kana, Nomoto, Takahiro, El, Muttaqien S., Muttaqien, S, Takemoto, Hiroyasu, Matsui, Makoto, Miura, Yutaka, Nishiyama, Nobuhiro
Publikováno v:
Cancer Science
Cancer cells have high iron requirements due to their rapid growth and proliferation. Iron depletion using iron chelators has a potential in cancer treatment. Previous studies have demonstrated that deferoxamine (DFO) specifically chelates Fe(III) an
Publikováno v:
Cancer Science
Trastuzumab deruxtecan (T‐DXd: DS‐8201a) is an anti‐human epidermal growth factor receptor 2 (HER2) Ab–drug conjugated with deruxtecan (DXd), a derivative of exatecan. The objective of this study was to characterize T‐DXd‐induced lung tox