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of 122
pro vyhledávání: ''
Autor:
Tetsu Hayashida, Aiko Nagayama, Tomoko Seki, Maiko Takahashi, Akiko Matsumoto, Anna Kubota, Hiromitsu Jinno, Hiroaki Miyata, Yuko Kitagawa
Publikováno v:
Cancer Science. 113:1722-1730
Due to the increasing complexity of cancer treatment, ensuring safety and maintaining the quality of life during treatment are important issues. Patient-reported outcomes (PROs) in oncology are essential for assessing patient symptoms. A feasibility
Autor:
Kaori Togashi, Akira Yamauchi, Hironori Kato, Nobuhiko Shinkura, Kenichi Yoshida, Kosuke Kawaguchi, Takahiro Yamada, Ryuji Okamura, Masahiro Sugimoto, Eiji Suzuki, Hironori Haga, Masae Torii, Hirofumi Suwa, Norimichi Kan, Sachiko Takahara, Yoshiaki Matsumoto, Masahiro Kawashima, Tsuyoshi Tachibana, Masakazu Toi, Yukiko Inagaki-Kawata, Hiroshi Yoshibayashi, Takashi Inamoto, Masako Kataoka, Shingo Sakata, Nobuko Kawaguchi-Sakita, Fumiaki Yotsumoto, Kazuhiko Yamagami, Yuki Kataoka, Mitsuru Tanaka, Shinji Kosugi, Masahiro Takada, Seishi Ogawa, Shigeru Tsuyuki, Tomomi Nishimura, Susumu Mashima, Noriko Senda, Yoshio Moriguchi
Publikováno v:
Cancer Science
Predicting pathogenic germline variants (PGVs) in breast cancer patients is important for selecting optimal therapeutics and implementing risk reduction strategies. However, PGV risk factors and the performance of prediction methods in the Japanese p
Autor:
Taichi Hagio, Seiichi Mori, Sayuri Amino, Takeshi Nakajima, Tetsuo Noda, Tomoko Kaneyasu, Seigo Nakamura, Masaaki Matsuura, Tomo Osako, Noriko Yaguchi, Toru Hirota, Eri Nakashima, Dai Kitagawa, Takayuki Ueno, Reiko Yoshida, Osamu Gotoh, Norio Tanaka, Shinji Ohno, Yoshio Miki, Shunji Takahashi
Publikováno v:
Cancer Science
Genes involved in the homologous recombination repair pathway—as exemplified by BRCA1, BRCA2, PALB2, ATM, and CHEK2—are frequently associated with hereditary breast and ovarian cancer syndrome. Germline mutations in the loci of these genes with l
Autor:
Miki Nagatsuka, Seiichiro Masui, Miwako K. Homma, Yuichiro Kiko, Yoshimi Homma, Naoto Katagata, Yuko Hashimoto, Tadashi Nomizu
Publikováno v:
Cancer Science
Overexpression of the ubiquitous protein kinase, CK2α, has been reported in various human cancers. Here, we demonstrate that nuclear and nucleolar CK2α localization in invasive ductal carcinomas of the breast is a reliable predictor of poor prognos
Autor:
Hsin-Han Chang, Hao-Chung Tsai, Chieh-Yung Wang, Chih-Ying Changchien, Li-Ting Cheng, Ying Chen, Ming-Sheng Shen, Ming-Shen Dai, Chen-Liang Tsai, Wen-Chiuan Tsai, Herng-Sheng Lee
Publikováno v:
Cancer Science
Malignant pleural effusion is a common complication in metastatic breast cancer (MBC); however, changes in the pleural microenvironment are poorly characterized, especially with respect to estrogen receptor status. Histologically, MBC presents with i
Autor:
Mitsuru Emi, Yumi Tsuboi, Kaoru Mogushi, Takeshi Ito, Yuka Takahashi, Fumi Murakami, Yoshinori Murakami, Yoshiya Horimoto, Daisuke Matsubara, Mitsue Saito, Tatsuhiro Shibata
Publikováno v:
Cancer Science
Copy number variation (CNV) is a polymorphism in the human genome involving DNA fragments larger than 1 kb. Copy number variation sites provide hotspots of somatic alterations in cancers. Herein, we examined somatic alterations at sites of CNV in DNA
Autor:
Mitsue Saito, May Thinzar Hlaing, Atsushi Arakawa, Emi Tokuda, Shuji Matsuoka, Ritsuko Sasaki, Yoshiya Horimoto, Shigehisa Kitano, Harumi Saeki, Katsuya Nakai, Masami Arai, Naomi Otsuji, Aiko Kurisaki-Arakawa
Publikováno v:
Cancer Science
The frequency of microsatellite instability (MSI) is reportedly extremely low in breast cancer, despite widespread clinical expectations that many patients would be responsive to immune‐checkpoint inhibitors (ICI). Considering that some triple‐ne
Autor:
Yukie Nishiyama, Yuta Ibuki, Hidetoshi Tahara, Shinsuke Sasada, Junko Tanaka, Takayuki Kadoya, Yuki Yamamoto, Ryou‐u Takahashi, Yumiko Koi, Morihito Okada, Norio Masumoto, Tomoyuki Akita, Yasuhiro Tsutani, Daisuke Ueda
Publikováno v:
Cancer Science
Emerging evidence indicates that small RNAs, including microRNAs (miRNAs) and their isoforms (isomiRs), and transfer RNA fragments (tRFs), are differently expressed in breast cancer (BC) and can be detected in blood circulation. Circulating small RNA
Autor:
Takahito Jomori, Yoichi Nakanishi, Miwa Noda, Takaaki Masuda, Shinji Ohno, Dai Kitagawa, Keiichi I. Nakayama, Takahiro Kogawa, Naoki Hayashi, Koshi Mimori
Publikováno v:
Cancer Science
The formation of premetastatic niches creates a fertile environment for the seeding of disseminated cancer cells in selected secondary organs. This is crucial for the development of metastasis in various malignancies, including breast cancer (BC). We
Autor:
Li Hu, Tianfeng Wang, Tie Fan, Jinfeng Li, Zhaoqing Fan, Ye Xu, Benyao Lin, Yuntao Xie, Tao Ouyang, Z. Fan
Publikováno v:
Cancer Science
BRCA1/2 genes are the most frequently germline mutated DNA‐repair genes, and the survival of BRCA1/2 carriers has been extensively explored in breast cancer. However, the prevalence of germline mutations in non‐BRCA1/2 DNA‐repair genes and the