Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tapan M. Kadia"'
Autor:
Tapan M. Kadia, Hagop Kantarjian, Gheath Alatrash, Anna Sergeeva, Hong He, Lisa St. John, Priya Koppikar, Celine Kerros, Abhishek Maiti, Courtney Dinardo, Elias Jabbour, Serge Vesrstovsek, Naveen Pemmaraju, Nitin Jain, Ghayas Issa, Guillermo Montalban-Bravo, Aditi Shastri, Daniel Couriel, Rhona Pinsoy, Sapna Parshottam, Richard Champlin, Jorge Cortes, Jeffrey Molldrem
Publikováno v:
Cancer Research. 83:CT101-CT101
Background: Despite recent advances in the treatment of AML, most approaches are rarely curative and most patients (pts) succumb to relapsed disease. The effectiveness of stem cell transplant and associated graft vs. leukemia effect implies an import
Autor:
Christine E. Birdwell, Warren C. Fiskus, Tapan M. Kadia, Christopher P. Mill, John A. Davis, Kaberi Das, Stephen Horrigan, Kapil N. Bhalla
Publikováno v:
Cancer Research. 83:4900-4900
EVI1 gene is located at 3q26.2 in the MECOM locus and encodes for a zinc-finger transcription factor. Chromosome translocation t(3;3) or inv(3) at 3q26 repositions the enhancer (E) of the tumor suppressor GATA2 to induce EVI1 over-expression, while c
Autor:
Warren C. Fiskus, Jessica Piel, Murphy Hentemann, Christopher P. Mill, Christine E. Birdwell, Kaberi Das, John A. Davis, Tapan M. Kadia, Naval Daver, Sanam Loghavi, Courtney D. DiNardo, Kapil N. Bhalla
Publikováno v:
Cancer Research. 83:1140-1140
ATP-dependent chromatin remodeling BAF (BRG1/BRM-associated factor) complexes bind and enable transcription factors (TFs) and co-factors to gain access to enhancer/promoter DNA and modulate transcription. In BAF complexes, The BRG1 (SMARCA4) or BRM (
Autor:
Christine Birdwell, Warren C. Fiskus, Christopher P. Mill, John A. Davis, Qi Jin, Courtney D. DiNardo, Koichi Takahashi, Stephen Horrigan, Tapan M. Kadia, Naval Daver, Kapil N. Bhalla
Publikováno v:
Cancer Research. 82:2648-2648
The EVI1 gene is located on 3q26.2 and encodes a zinc fingers-containing transcription factor. Nuclear β-catenin-TBL1/R1-TCF7L2 axis activity and EVI1 expression characterize leukemia stem-progenitor cells, supporting their self-renewal and blocking
Abstract 4028: Menin inhibitor-based combinations to improve efficacy and overcome resistance in AML
Autor:
Warren C. Fiskus, Christopher P. Mill, Christine Birdwell, John A. Davis, Qi Jin, Tapan M. Kadia, Courtney D. DiNardo, Koichi Takahashi, Gerard M. McGeehan, Naval Daver, Kapil N. Bhalla
Publikováno v:
Cancer Research. 82:4028-4028
In MLL1 rearranged (MLL1r) AML (~10%), N-terminus of MLL1 gene is fused to the C-terminus of a fusion partner, e.g. AF9, AF4, ENL and ELL, creating MLL1 fusion protein (MLL-FP), which increases expression of leukemogenic HOXA9 and its co-factor MEIS1
Autor:
Carlos E. Bueso-Ramos, Michael Andreeff, Steven M. Kornblau, William G. Wierda, James P. Allison, Tapan M. Kadia, Srdan Verstovsek, Jairo Matthews, Naval Daver, Nitin Jain, Narmeen Somani, Hagop M. Kantarjian, Padmanee Sharma, Jorge E. Cortes, Marina Konopleva, Hui Yang, Gautam Borthakur, Guillermo Garcia-Manero, Peter P. Ruvolo, Wilmer Flores, Jorge Blando, Farhad Ravandi, Sreyashi Basu
Publikováno v:
Cancer Research. 76:3205-3205
Introduction: The expression of co-stimulatory (costim) receptors/ligands in the bone marrow (BM) and peripheral blood (PB) in patients (pts) with AML has not been defined. Identification of immune-checkpoint pathways that dominate in AML will guide
Autor:
Tapan M. Kadia, Guillermo Garcia Manero, Nitin Jain, Naval Daver, Naveen Pemmaraju, Courtney D. DiNardo, G. Borthakur, Hagop M. Kantarjian, Jorge E. Cortes, Farhad Ravandi, Craig Adam
Publikováno v:
Cancer Research. 74:CT307-CT307
Background: Vosaroxin (formerly voreloxin), is a quinolone derived DNA topoisomerase II inhibitor, which is not a substrate for p53 or P-glycoprotein and has limited toxicity; it is currently under evaluation for the treatment of pts with AML and hig
Autor:
Peter P. Ruvolo, Hagop M. Kantarjian, Elihu H. Estey, Jan A. Burger, Roland B. Walter, Stefan Faderl, Michael Andreeff, Zhihong Zeng, Keith A. Baggerly, Gautam Borthakur, Xuelin Huang, Tapan M. Kadia, Wenbin Liu, Jennie Feliu, Marina Konopleva, Elias Jabbour, Steven M. Kornblau
Publikováno v:
Cancer Research. 73:LB-293
Outcomes of adults with AML remain unsatisfactory. To explore the role of the AKT signaling pathway in AML, we examined samples from AML patients (pts) utilizing reverse phase protein arrays (RPPAs). High levels of the phosphorylated Ser473 form of A
Publikováno v:
Cancer Research. 73:592-592
Genomic instability and impaired DNA repair are features of acute myeloid leukemia (AML). DNA damaging agents such as cyclophosphamide and anthracyclines exert their antileukemic activity by generating widespread genomic damage, coupled with ineffici