Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sven Perner"'
Autor:
Isabel Porth, Philip Weidner, Sylvie Lorenzen, Wilko Weichert, Thorsten Oliver Götze, Sven Perner, Kim Luley, Daniela Hirsch, Ralf-Dieter Hofheinz, Diana B. Peckys, Zahra Mostajeran, Niels de Jonge, Timo Gaiser
Publikováno v:
Cancer Research. 82:4018-4018
Since 2010, Trastuzumab combined with chemotherapy is the standard treatment for patients with HER2 (ERBB2) positive advanced or metastatic gastric and gastroesophageal junction cancer (GGEJ). While few patients show long-term response to the treatme
Autor:
U. Leeser, Martin Peifer, Tsun-Po Yang, Reinhard Büttner, Sven Perner, Daniela Welcker, Michael Nowak, Anna Schmitt, Gero Knittel, Hans Christian Reinhardt, Julie George
Publikováno v:
Cancer Research. 77:3040-3056
Defects in maintaining genome integrity are a hallmark of cancer. The DNA damage response kinase ATM is frequently mutated in human cancer, but the significance of these events to chemotherapeutic efficacy has not been examined deeply in whole organi
Autor:
Petra M. Bareiss, Falko Fend, Klaus Schulze-Osthoff, Ursula Kohlhofer, Hui Wang, Stefan Wiehr, Anna M. Paczulla, Bernd J. Pichler, Leticia Quintanilla-Martinez, Rebekka Schairer, Annette Staebler, Tanja Fehm, Diethelm Wallwiener, Oliver Rothfuss, Sven Perner, Anna Fischer, Lothar Kanz, Frank Essmann, Claudia Lengerke
Publikováno v:
Cancer Research. 73:5544-5555
The SRY-related HMG-box family of transcription factors member SOX2 regulates stemness and pluripotency in embryonic stem cells and plays important roles during early embryogenesis. More recently, SOX2 expression was documented in several tumor types
Autor:
Francis Jacob, Zsuzsanna Varga, Thorsten Schaefer, Martina Konantz, Anna M. Paczulla, Lothar Kanz, Hui Wang, Martin Braun, Tanja Fehm, Klaus Schulze-Osthoff, Sven Perner, Claudia Lengerke, Selina Reich, Holger Moch
Publikováno v:
Cancer research
Overexpression of the EVI1 oncogene is associated typically with aggressive myeloid leukemia, but is also detectable in breast carcinoma where its contributions are unexplored. Analyzing a tissue microarray of 608 breast carcinoma patient specimens,
Autor:
Rosemarie Krupar, Brett A. Miles, Krzys Misiukiewicz, Michael J. Donovan, Jigneshkumar Patel, Sven Perner, Sacha Gnjatic, Naoko Imai, Falguni Parikh, Andrew G. Sikora, Marshall R. Posner, Elizabeth G. Demicco, Seunghee Kim-Schulze, Ravi Ramesh Pathak, Eric M. Genden
Publikováno v:
Cancer Research. 78:5639-5639
Human papilloma virus associated oropharyngeal cancers (HPVOPC) account for about one third of OPC and express foreign viral antigens such as the E6 and E7 oncogenes, which are suitable for immune targeting. We performed a “window of opportunity”
Autor:
Carolin Bossmann, Jessica Carlsson, Glen Kristiansen, Michael D. Nowak, Yuri Tolkach, Sven Perner, Ove Andrén, Constanze Merz
Publikováno v:
Cancer Research. 77:2559-2559
Background: FoxF1 belongs to the family of forkhead box transcription factors. Many forkhead box proteins are linked to cancer development and progression. However, the regulation and exact function of FoxF1 remains unclear. The aim of this study was
Autor:
Lothar Kanz, Tanja Fehm, Sven Perner, Holger Moch, Thorsten Schaefer, Hui Wang, Martina Konantz, Martin Braun, Klaus Schulze-Osthoff, Zsuszanna Varga, Claudia Lengerke, Selina Reich
Publikováno v:
Cancer Research. 76:2015-2015
Ecotropic viral integration site1 (EVI1) is a transcriptional regulator that is essential for the maintenance of hematopoietic stem cells and, when overexpressed in leukemia, associates with particularly aggressive disease. EVI1 expression has also b
Publikováno v:
Cancer Research. 76:2910-2910
SOX2 (SRY (sex determining region Y)-box 2) is a transcriptional master regulator that confers “stemness” in early embryogenesis and acts as an oncogene in various cancers. Recently, SOX2 expression has been shown in several solid tumor types. Ho
Autor:
Tamara C. Pereboom, Martina Konantz, Oliver K. Rothfuss, Tanja Fehm, Britta Merz, Thorsten Schaefer, Hui Wang, Sven Perner, Klaus Schulze-Osthoff, Claudia Lengerke, Perihan Mir, Lothar Kanz
Publikováno v:
Cancer Research. 76:PR06-PR06
The pluripotency-associated transcription factor SOX2 (Sex determining region Y - Box 2) is a key regulator of early organogenesis and embryonic stem cell fate. Supporting the notion that embryonic pathways may reactivate during oncogenesis, SOX2 exp
Autor:
Sven Perner, Hui Wang, Thorsten Schäfer, Zsuzsanna Varga, Selina Reich, Martin Braun, Claudia Lengerke, Lothar Kanz, Holger Moch, Martina Konantz, Klaus Schulze-Osthoff
Publikováno v:
Cancer Research. 76:A45-A45
Ecotropic viral integration site 1 (EVI1) is a nuclear transcription factor essential for the maintenance of hematopoietic stem cells. Aberrant expression of EVI1 is found in ~10% of acute myeloid leukemia, where it associates with particularly aggre