Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Ross, L"'
Autor:
Florian Perner, Sheng F. Cai, Daniela V. Wenge, Jeonghyeon Kim, Jevon Cutler, Radosław P. Nowak, Joel Cassel, Shivendra Singh, Shipra Bijpuria, William H. Miller, Eytan M. Stein, Ross L. Levine, Eric S. Fischer, Gerard M. McGeehan, Scott A. Armstrong
Publikováno v:
Cancer Research. 83:3457-3457
The menin-MLL1 interaction is critical for development of acute leukemias driven by MLL1 rearrangements (MLLr) or mutations in the Nucleophosmin 1 gene (NPM1c). Inhibition of the menin-MLL1 interaction by SNDX-5613 (revumenib) has demonstrated robust
Autor:
Jie Xu, Fan Song, Baozhen Zhang, Huijue Lyu, Mikoto Kobayashi, Ziyu Zhao, Ye Hou, Xiaotao Wang, Yu Luan, Bei Jia, Lena Stasiak, Qixuan Wang, Qi Jin, Qiushi Jin, Yihao Fu, Ross C. Hardison, Sinisa Dovat, Leonidas C. Platanias, Yue Yang, Tomoko Yamada, Aaron D. Viny, Ross L. Levine, David F. Claxton, James R. Broach, Hong Zheng, Feng Yue
Publikováno v:
Cancer Research. 82:2953-2953
Acute myeloid leukemia (AML) represents a set of heterogeneous myeloid malignancies hallmarked by mutations in epigenetic modifiers, transcription factors, and kinases that can cause epigenetic reshaping. It is unclear to what extent AML mutations dr
Autor:
Robinson Triboulet, Khikmet Sadykov, Jessica L. Johnson, Andrew R. Snyder, Sarah K. Knutson, Pavan Kumar, Christopher B. Mayo, Dillon Hawley, Andrew Madanjian, Ross L. Stein, David M. Wilson, Darren M. Harvey, Shomir Ghosh, Robert M. Campbell
Publikováno v:
Cancer Research. 82:1822-1822
The purpose of the study was to determine if genetic and pharmacological inhibition of terminal uridyltransferases (TUTases) ZCCHC11 and ZCCHC6 could modulate Glioblastoma (GBM) cell growth in vitro. ZCCHC11 (also known as TUT4 and TENT3A) and ZCCHC6
Autor:
Sarah P. Suehnholz, Moriah Nissan, Hongxin Zhang, Ritika Kundra, Calvin Lu, Benjamin Xu, Maria E. Arcila, Marc Ladanyi, Michael F. Berger, Ahmet Zehir, Aijaz Syed, Julia E. Rudolph, Ross L. Levine, Ahmet Dogan, Jianjiong Gao, David B. Solit, Nikolaus Schultz, Debyani Chakravarty
Publikováno v:
Cancer Research. 82:1189-1189
OncoKB, Memorial Sloan Kettering Cancer Center’s (MSK) precision oncology knowledge base (www.oncokb.org), is a comprehensive database that annotates the oncogenic effects and clinical actionability of somatic alterations in cancer. OncoKB supports
Publikováno v:
Cancer Research. 78:4344-4359
A key tool of cancer therapy has been targeted inhibition of oncogene-addicted pathways. However, efficacy has been limited by progressive emergence of resistance as transformed cells adapt. Here, we use Drosophila to dissect response to targeted the
Autor:
Moriah H. Nissan, Kinisha Gala, Linde A. Miles, Debyani Chakravarty, Paul Sabbatini, Shaleigh A. Smith, Hongxin Zhang, Aijaz Syed, Ahmet Zehir, Sarah P. Suehnholz, Ahmet Dogan, Julia E. Rudolph, Maria E. Arcila, Ritika Kundra, Yifu Yao, Jianjiong Gao, Nikolaus Schultz, Michael F. Berger, Marc Ladanyi, Ross L. Levine, Lindsay M. LaFave, David B. Solit
Publikováno v:
Cancer Research. 81:99-99
Genomic sequencing of tumors is a routine part of cancer patient care. To address the need for a comprehensive resource that annotates the oncogenic effects and clinical actionability of somatic alterations in cancer, we developed OncoKB, a precision
Autor:
Quang M. Trinh, Amanda I. Phipps, Tameka Shelford, Syed H.E. Zaidi, Wei Sun, Ross L. Prentice, Stephen N. Thibodeau, Marc J. Gunter, Daniel D. Buchanan, Andrew T. Chan, Marios Giannakis, Li Hsu, Conghui Qu, Shuji Ogino, Peter T. Campbell, Sonja I. Berndt, David A. Drew, Ulrike Peters, Steven Gallinger, Andrea Gsur, Wen-Yi Huang, Paul J. Limburg, Victor Moreno, Robert S. Steinfelder, Kim F. Doheny, Tabitha A. Harrison, Michael Hoffmeister, Jane C. Figueiredo, Polly A. Newcomb
Publikováno v:
Cancer Research. 81:LB090-LB090
Colorectal cancer (CRC) is a heterogenous disease that develops through somatic mutations in driver genes, leading to activation of diverse neoplastic pathways. To systematically examine if somatically mutated genes and pathways impact survival, we s
Autor:
Marc J. Gunter, Ulrike Peters, Andrew T. Chan, Stephen B. Gruber, Niki Dimou, Feng Guo, Victor Moreno, Hermann Brenner, Li Hsu, Michael Hoffmeister, Peter T. Campbell, Elizabeth A. Platz, Sonja I. Berndt, Jenny Chang-Claude, Emily White, Yu Tian, Ross L. Prentice, William J. Gauderman, Andre E. Kim, Xuechen Chen, Yi Lin, Stephanie A. Bien, Graham Casey, Amit Joshi, Polly A. Newcomb, Loic Le Marchand
Publikováno v:
Cancer Research. 81:818-818
Background and objective Genetic predisposition and menopausal hormone therapy (MHT) are established risk and preventive factors for colorectal cancer (CRC), respectively. We aimed to evaluate the joint associations of a polygenic risk score (PRS) an
Autor:
Kyle Dzwigalski, Alan H. Shih, Allison M. Mustonen, Mitch A. Phelps, Ross L. Levine, Amy Lehman, Jean Truxall, Kasey Hill, Bonnie K. Harrington, Thomas E. Goodwin, Mariah L. Johnson, Ola A. Elgamal, Erin Hertlein, John C. Byrd, Chad Bennett
Publikováno v:
Cancer Research. 80:6118-6118
Introduction Acute myeloid leukemia (AML) is a disease characterized by the proliferation of undifferentiated myeloid blasts, promoting bone marrow failure, infectious complications, and death. Progress in developing treatments for AML has been slow
Autor:
Chad M. Vanderbilt, Paul Sabbatini, Hongxin Zhang, Debyani Chakravarty, Marc Ladanyi, Nikolaus Schultz, Ahmet Dogan, Ahmet Zehir, Maria E. Arcila, Sarah P. Suehnholz, Lindsay M. LaFave, Moriah H. Nissan, Ross L. Levine, Jing Su, Kinisha Gala, Jianjiong Gao, Ritika Kundra, David B. Solit, Michael F. Berger, Julia E. Rudolph
Publikováno v:
Cancer Research. 80:3208-3208
OncoKB is a precision oncology knowledge base that annotates the oncogenic effects and clinical actionability of somatic alterations in cancer. Initially focused on solid tumors, OncoKB was introduced in 2016 with >200 genes and almost 3000 somatic a