Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Paolo Fortina"'
Autor:
Patrizia Porazzi, Svetlana Petruk, Luca Pagliaroli, Marco De Dominici, David Deming, Matthew V. Puccetti, Saul Kushinsky, Gaurav Kumar, Valentina Minieri, Elisa Barbieri, Sandra Deliard, Alexis Grande, Marco Trizzino, Alessandro Gardini, Eli Canaani, Neil Palmisiano, Pierluigi Porcu, Adam Ertel, Paolo Fortina, Christine M. Eischen, Alexander Mazo, Bruno Calabretta
Publikováno v:
Cancer Res
Despite treatment with intensive chemotherapy, acute myelogenous leukemia (AML) remains an aggressive malignancy with a dismal outcome in most patients. We found that AML cells exhibit an unusually rapid accumulation of the repressive histone mark H3
Autor:
Weijia Cai, Adam E. Snook, McKenna Glasheen, Inna Chervoneva, Sheera Rosenbaum, Ayako Shimada, Mai Q. Nguyen, Andrew E. Aplin, Danielle Pomante, Claudia Capparelli, Xiaowei Xu, Manoela Tiago, Kim HooKim, Timothy J. Purwin, Michael A. Davies, Meenhard Herlyn, Edna Cukierman, Gaurav Kumar, Nicole A. Wilski, Richard Zheng, Paolo Fortina
Publikováno v:
Cancer Research. 81:40-40
Intratumoral heterogeneity and cellular plasticity enable tumors to alter phenotypes and adapt to foreign microenvironments and resist targeted inhibitors. While the ability to switch between phenotypic states has been broadly characterized, the key
Publikováno v:
Cancer Research. 80:5469-5469
A typical genomic sequencing experiment results in a long list of statistically significant variant candidates among protein-coding genes without any unifying biological theme. This leads to a daunting task of identifying the causal variants and gene
Autor:
Rebecca J. Nagy, Angel Rodriguez, Massimo Cristofanilli, Amir Ali Talasaz, Oliver A. Zill, Laura Austin, Paolo Fortina, Rebecca Jaslow
Publikováno v:
Cancer Research. 76:P3-05
Background About 65% of breast cancers express the estrogen receptor α and the mainstay of treatment are therapies that result in estrogen receptor modulation (selective estrogen receptor modulators, SERMs) or estrogen deprivation (aromatase inhibit
Autor:
Marco, De Dominici, Patrizia, Porazzi, Angela Rachele, Soliera, Samanta A, Mariani, Sankar, Addya, Paolo, Fortina, Luke F, Peterson, Orietta, Spinelli, Alessandro, Rambaldi, Giovanni, Martinelli, Anna, Ferrari, Ilaria, Iacobucci, Bruno, Calabretta
Publikováno v:
Cancer research. 78(4)
Philadelphia Chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is currently treated with BCR-ABL1 tyrosine kinase inhibitors (TKI) in combination with chemotherapy. However, most patients develop resistance to TKI through BCR-ABL1-dependent
Autor:
Mathew C. Casimiro, Er Chen, Anthony A. Sauve, Adam Ertel, Sankar Addya, Paolo Fortina, Michael J. Powell, Richard G. Pestell, Chenguang Wang, R Soccio, H Deng, Jie Zhou, Fred K. Hagen, Michael P. Lisanti, Zhijiu Zhong, P Xu, Michael Gormley, Lifeng Tian
Publikováno v:
Cancer Research. 73:P2-06
Peroxisome proliferator-activated receptorg (Pparγ) is a member of the nuclear receptor (NR) superfamily, which regulates diverse biological functions including lipogenesis and differentiation, anti-inflammation, insulin sensitivity, cellular prolif
Autor:
Min Wang, Michael Gormley, Emanuele Loro, Chenguang Wang, Richard G. Pestell, Xiaoming Ju, Z Liu, Adam Ertel, Mathew C. Casimiro, Aydin Tozeren, Y Chen, Kongming Wu, Liping Wang, Ke Chen, Zuoren Yu, Paolo Fortina
Publikováno v:
Cancer Research. 73:P4-07
MicroRNAs (miRNAs), a class of non-coding small RNA, regulate gene expression through base-pairing binding to the complementary sequence in the 3’ untranslated region (3’ UTR) of mRNA. miRNAs contribute to the timing of development, apoptosis, ce
Autor:
Massimo Cristofanilli, LaiMun Siew, AmirAli Talasaz, Benjamin J Schiller, Gangwu Mei, Laura Austin, Helmy Eltoukhy, Dragan Sebisanovic, Paolo Fortina, Aubrey Zapanta
Publikováno v:
Cancer Research. 75:P2-04
Background Inflammatory Breast Cancer (IBC) is a clinicopathologic diagnosis characterized by rapid progression, resistance to treatment and poor prognosis. It is often an incurable disease with complex molecular features including somatic mutations
Autor:
Adam Ertel, Peter McCue, Zuoren Yu, Xiaoming Ju, Richard G. Pestell, Paolo Fortina, Rhonda Walters, Michael P. Lisanti, Hui Meng, Mathew C. Casimiro
Publikováno v:
Cancer Research. 73:978-989
Herein, murine prostate cancer cell lines, generated via selective transduction with a single oncogene (c-Myc, Ha-Ras, and v-Src), showed oncogene-specific prostate cancer molecular signatures that were recapitulated in human prostate cancer and deve
Autor:
Chenguang Wang, Richard G. Pestell, Emanuele Loro, Alexandros Papanikolaou, Zuoren Yu, Adam Ertel, Sankar Addya, Paolo Fortina, Zhaoming Li, Will Dampier, Erik S. Knudsen, Elizabeth A. Saria, Mathew C. Casimiro, Marco Crosariol, Andrew Arnold, Michael P. Lisanti, G Di Sante, Aydin Tozeren
Publikováno v:
Cancer Research. 73:P5-07
Cyclin D1 is an important molecular driver of human breast cancer but better understanding of its oncogenic mechanisms is needed, especially to enhance efforts in targeted therapeutics. Activation of the cyclin D1 oncogene, often by amplification or