Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Olivier Rixe"'
Autor:
Olivier Rixe, Vincent Castonguay, Henry Conter, Eva Chalas, Pratibha Desai, Christian Squillante, Lisa A. MacDonald, Rebekah Conlon, Yogesh Bramhecha, Heather Hirsch, Jeremy R. Graff, Stephan Fiset
Publikováno v:
Cancer Research. 82:CT035-CT035
Background: Maveropepimut-S (MVP-S) is a novel immunotherapeutic that educates a specific CD8 T cell response to the cancer antigen, survivin, to orchestrate immune-mediated elimination of survivin-expressing cancer cells. Specifically, MVP-S is a li
Autor:
Alain C. Mita, David Martin Darst, Michael A. Postow, Angela Jain, Celia Andreu, Robert Wasserman, Robert Busby, Gerald Steven Falchook, Igor Puzanov, Erika Hamilton, Michael Szarek, Tomislav Dragovich, Narayan Lebaka, Eric K. Rowinsky, Rebecca Redman, Monica M. Mita, Masoud Tavazoie, Shubham Pant, Isabel Kurth, Olivier Rixe, Syed Ahsan Raza, Russell J. Schilder, Kevin B. Kim, R. Donald Harvey, Foster C. Gonsalves, Emerson A. Lim, James Strauss, Bartosz Chmielowski
Publikováno v:
Cancer Research. 80:CT146-CT146
Background: RGX-104 is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene. Binding of ApoE to its receptor LRP8 robustly inhibits angiogenesis and depletes myeloid derived suppressor cells (MDS
Autor:
Olivier Rixe, Timothy M. Kuzel, David Smith, Martin Gutierrez, Sahar Ansari, John A. Thompson, Sanjay Goel, Andrew L. Coveler, Michael W. Schmitt, Thomas F. Gajewski, David L. Bajor, Haley Neff-LaFord, Shyra Gardai, Elisabeth I. Heath, Brendan D. Curti, Svetomir N. Markovic, Celine Jacquemont, Juneko E. Grilley-Olson
Publikováno v:
Cancer Research. 80:5535-5535
CD40 is a co-stimulatory receptor of the TNF receptor superfamily expressed on antigen presenting cells (APCs). Antibodies targeting CD40 may have therapeutic benefit via multiple mechanisms including innate immune activation that can support generat
Autor:
Olivier Rixe, Mohammed M. Milhem, David H. Munn, Yousef Zakharia, Eugene P. Kennedy, Samir N. Khleif, Joseph J. Drabick, Nicholas N. Vahanian, Montaser Shaheen, Charles J. Link
Publikováno v:
Cancer Research. 76:CT087-CT087
Background: IDO is an enzyme that catalyzes the initial and rate limiting step in the conversion of tryptophan to kynurenine. Tryptophan depletion enhances the number and function of the Treg (suppressive) arm of the immune system and inhibits the ef
Autor:
Yong Teng, Olivier Rixe, Junfeng Luo, John K. Cowell, Zhengtao Chu, Xiaoyang Qi, Theodore S. Johnson, Franck Cuttitta, Minghui Li
Publikováno v:
Cancer Research. 74:1023-1023
NOV (Nephroblastoma OVerexpressed) C-ter (NOV C-ter) is the carboxy-terminal sequence (170aa) of NOV/CCN3 protein. NOV/CCN3 (357aa), a member of CCN family, is secreted by quiescent endothelial cells and is involved in the regulation of various cellu