Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Natalia Baran"'
Autor:
Bofei Wang, Christopher Ly, Fatima Zahra Jelloul, Enes Dasdemir, Guilin Tang, Sonali Jindal, Yulong Chen, Sreyashi Basu, Poonam Desai, Pamella Borges, Preethi Gunaratne, Natalia Baran, Qing Deng, Dapeng Hao, Sean Post, Michael Green Green, Marina Konopleva, Andy Futreal, Padmanee Sharma, Hussein A. Abbas
Publikováno v:
Cancer Research. 83:5927-5927
Acute Myeloid Leukemia (AML) is a heterogenous disease characterized by immature blasts at different states of differentiation resulting in marked intra-tumor heterogeneity (ITH). Compared to patients with diploid cytogenetics, deletions in chromosom
Autor:
Katie H. Hurrish, Yongwei Su, Shraddha Patel, Sandra E. Wiley, Zhanjun Hou, Jenna Carter, Hasini Kalpage, Maik Hüttemann, Connie Weng, Holly Edwards, Lisa Polin, Jing Li, Jay Yang, Larry H. Matherly, Sergej Naumovich Konoplev, Jeffrey W. Taub, Marina Konopleva, Yubin Ge, Natalia Baran
Publikováno v:
Cancer Research. 82:3785-3785
Acute myeloid Leukemia (AML) is an aggressive hematologic malignancy with poor prognosis. Despite chromosomal and genetic heterogeneity, AML are uniformly characterized by increased reliance on oxidative phosphorylation (OXPHOS). This key metabolic h
Autor:
Priyanka Sharma, Sujan Piya, Huaxian Ma, Natalia Baran, Muharrem Muftuoglu, Mahesh Basyal, Vivian Ruvolo, George Ward, Tomoko Smyth, Martin J. Sims, Michael Andreeff, Gautam Borthakur
Publikováno v:
Cancer Research. 82:5337-5337
Background: Inhibitors of apoptosis proteins (IAPs) are overexpressed in ALL leading to resistance to apoptosis and chemo-resistance. Tolinapant, a non-peptidomimetic antagonist of the cellular and X-linked inhibitors of apoptosis (cIAP1/2 and XIAP)
Publikováno v:
Cancer Research. 75:940-949
Acute myeloid leukemia (AML) is a heterogeneous disease in which a variety of distinct genetic alterations might occur. Recent attempts to identify the leukemia stem-like cells (LSC) have also indicated heterogeneity of these cells. On the basis of m
Autor:
Marina Konopleva, Anna Skwarska, Shelley Herbrich, Vivian Ruvolo, Erick Morris, Peter P. Ruvolo, Donia M Moujalled, Qi Zhang, Michael Andreff, Ensar Halilovic, Natalia Baran, Andrew H. Wei
Publikováno v:
Cancer Research. 79:342-342
Myeloid cell leukemia 1 (Mcl-1) is one of the key anti-apoptotic Bcl-2 family proteins that binds and neutralizes pro-apoptotic BIM, BAX and BAK at the mitochondrial outer membrane, preventing cytochrome c release and caspase activation. Selective up
Autor:
Natalia Baran, Alessia Lodi, Shannon Sweeney, Vinitha Mary Kuruvilla, Antonio Cavazos, Anna Skwarska, Sriram Shanmuga Velandy, Karine Harutyunyan, Ningping Feng, Jason Gay, Marcin Kaminski, Elias J. Jabbour, Adolfo Ferrando, M. Emilia Di Francesco, Joseph R. Marszalek, Stefano Tiziani, Marina Konopleva
Publikováno v:
Cancer Research. 78:1875-1875
Adult T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with limited treatment options, largely driven by the activating Notch1 mutations. Oncogenic Notch1 facilitates c-Myc signaling and glutamine oxidation, induces