Zobrazeno 1 - 10
of 48
pro vyhledávání: '"M. Koch"'
Autor:
William H. Westra, Elana J. Fertig, Zubair Khan, Evgeny Izumchenko, Dzov A. Singman, Wayne M. Koch, Hildegard A. Wulf, Justin A. Bishop, Elena D. Stavrovskaya, Bahman Afsari, Ludmila Danilova, Dylan Z. Kelley, Alexander V. Favorov, Jane A. Welch, Theresa Guo, Daria A. Gaykalova, David Sidransky, Joseph A. Califano, Michael Considine, Sarah J. Wheelan, Alyza M. Skaist, Emily Flam
Publikováno v:
Cancer research, vol 77, iss 23
Chromatin alterations mediate mutations and gene expression changes in cancer. Chromatin immunoprecipitation followed by sequencing (ChIP-Seq) has been utilized to study genome-wide chromatin structure in human cancer cell lines, yet numerous technic
Autor:
Wayne M. Koch, Tal Hadar, Maartje G. Noordhuis, David Sidransky, Nishant Agrawal, Luigi Marchioni, Christina Michailidi, William H. Westra, Rafael Guerrero-Preston, Victor E. Velculescu, Elana J. Fertig, Joseph A. Califano
Publikováno v:
Cancer Research. 75:B1-62
For years studies have attempted to come up with measures and markers that predict and are linked to cancer survival. Alterations in a subgroup of genes, tumor suppressor genes (TSG), have recently emerged as important in linkage to cancer survival,
Autor:
Fabio Lievano, Scott Gulbranson, Martina M. Koch, Philip B. Komarnitsky, Jerzy Edward Tyczynski, Rui Jiang, Eros Papademetriou
Publikováno v:
Cancer Research. 78:1213-1213
Recent real-world data on comorbidities and concomitant medications in SCLC patients are scarce, particularly for later-lines of treatment. The purpose of this study was to describe comorbidities' pattern and concomitant medication use in SCLC patien
Autor:
Fabio Lievano, Martina M. Koch, Scott Gulbranson, Ravi Potluri, Philip B. Komarnitsky, Jerzy Edward Tyczynski, Mondira Bhattacharya, Rui Jiang
Publikováno v:
Cancer Research. 78:4228-4228
Small cell lung cancer (SCLC) is an aggressive, rapidly fatal disease. Pericardial and pleural effusions are, to a large extent, part of the natural history of lung cancer and the occurrences in SCLC may have differed due to novel therapies. We estim
Autor:
Zubair Khan, Sayed Sadat, Wayne M. Koch, Peter M. DeJong, Elana J. Fertig, J. Silvio Gutkind, Mizuo Ando, Daria A. Gaykalova, Joseph A. Califano, Chao Liu, Theresa Guo, Akihiro Sakai, Takahito Fukusumi, Sunny Haft, Alexander V. Favorov, Shuling Ren
Publikováno v:
Cancer Research. 78:3320-3320
Purpose: Human papillomavirus (HPV) related oropharyngeal squamous cell carcinoma (OPSCC) has an improved prognosis compared to cancers associated with tobacco and alcohol exposure, and also exhibits a different composition of epigenetic alterations.
Autor:
Martina M. Koch, Fabio Lievano, Charity Scripture, Jerzy Edward Tyczynski, Philip B. Komarnitsky, Ravi Potluri, Scott Gulbranson, Rui Jiang
Publikováno v:
Cancer Research. 78:4227-4227
While platinum-based combination chemotherapy is recommended for first-line treatment of small cell lung cancer (SCLC), the treatment for relapsed and refractory SCLC is heterogeneous with limited clinical benefit. Topotecan is the only approved seco
Autor:
William H. Westra, Barbara Mora-Lagos, James R. White, Filipa Godoy-Vitorino, Gustavo Rivera-Alvarez, Kelvin Navarro, David Sidransky, Winston Timp, Anne E. Jedlicka, Luigi Marchionni, Young J. Kim, Rafael Guerrero-Preston, Wayne M. Koch
Publikováno v:
Cancer Research. 78:570-570
We have previously shown altered microbiota in saliva from head and neck squamous cell carcinoma (HNSCC) patients, when compared to controls. We now applied high-resolution microbiome profiling (Resphera Insight) to analyze 16S rRNA sequencing and Ax
Autor:
Guojun Wu, Motonobu Osada, Zhongmin Guo, Alexey Fomenkov, Shahnaz Begum, Ming Zhao, Sunil Upadhyay, Mingzhao Xing, Feng Wu, Chulso Moon, William H. Westra, Wayne M. Koch, Roberto Mantovani, Joseph A. Califano, Edward Ratovitski, David Sidransky, Barry Trink
Publikováno v:
Cancer Research. 65:758-766
HSP70, a stress response protein, is known to be a determinant of cell death and cell transformation. We show that different isoforms of p63 have different transcriptional activities on hsp70 genes. ΔNp63α, an abundantly expressed isoform of p63, a
Autor:
Justin A. Bishop, William H. Westra, Theresa Guo, Dzov A. Singman, Elena D. Stavrovskaya, Ludmila Danilova, Alexander V. Favorov, Elana J. Fertig, Hildegard A. Wulf, Daria A. Gaykalova, David Sidransky, Joseph A. Califano, Wayne M. Koch, Emily Flam, Dylan Z. Kelley, Michael Considine, Evgeny Izumchenko, Zubair Khan, Sarah J. Wheelan
Publikováno v:
Cancer Research. 77:2424-2424
This project develops a novel experimental technique to perform ChIP-Seq (chromatin immunoprecipitation with massively parallel DNA sequencing) analysis of chromatin structure in primary tumor tissues from high risk HPV-related head and neck squamous
Autor:
William H. Westra, Amanda Dziedzic, Gustavo A. Miranda-Carboni, Rafael Guerrero-Preston, James R. White, Herminio González, Luigi Marchionni, David Sidransky, Stephanie Hao, Hyunseok Kang, Sierra Canapp, Filipa Godoy-Vitorino, Gustavo Rivera-Alvarez, Wayne M. Koch, Jessica Bondy, Anne E. Jedlicka, Kelvin Navarro, Young Ho Kim, Winston Timp, Barbara Mora Lagos, Christina Michailidi, Arnold Rodríguez-Hilario
Publikováno v:
Cancer Research. 77:1018-1018
Previous microbiome studies at the genus level have described altered microbiota in head and neck squamous cell carcinoma (HNSCC), both in terms of taxonomic composition and metabolic capacity. We applied high-resolution microbiome profiling (Respher