Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Julia E. McGuinness"'
Autor:
Andreas Varkaris, Erika Hamilton, Jason Henry, Alexander I. Spira, Alison M. Schram, Julia E. McGuinness, Gege Tan, Xiaoyan Li, Tamieka Hunter, Ramin Samadani, Alison Timm, Djuro Karanovic, Vivek Subbiah, Cesar A. Perez
Publikováno v:
Cancer Research. 83:OT3-22
Background: Targeting constitutively active mutant kinases with selective small molecule inhibitors is a key therapeutic pillar of precision oncology. Phosphatidylinositol-4,5bisphosphate-3 kinase, catalytic subunit alpha (PIK3CA) mutations leading t
Publikováno v:
Cancer Research. 82:P2-10
Background: Accurate assessment of a woman’s individualized breast cancer risk is necessary to inform shared decision-making regarding screening and risk-reducing strategies. Recently, deep learning techniques, including convolutional neural networ
Publikováno v:
Cancer Research. 83:PD16-02
Introduction: Digital breast tomosynthesis (DBT) is increasingly utilized in breast cancer screening, including among women at high risk for breast cancer. While there is a lack of rigorous data from randomized controlled trials demonstrating superio
Autor:
Luisa Nilan, Jacquelyn N. Amenta, Julia E. McGuinness, Rita Kukafka, Katherine D. Crew, Kehinde Lawal
Publikováno v:
Cancer Research. 83:P3-03
Background: Chemoprevention with selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) has been shown in randomized controlled trials to decrease breast cancer incidence by 50-65% among women at high risk for breast cancer. Ho
Autor:
Simukayi Mutasa, Julia E. McGuinness, Richard Ha, Katherine D. Crew, Jana Lee, Aishwarya Anuraj
Publikováno v:
Cancer Research. 81:PS5-21
Background: The standard of care for early-stage hormone receptor (HR)-positive breast cancer is 5-10 years of adjuvant endocrine therapy (ET), which is associated with a 50-60% relative risk reduction in breast cancer recurrence. However, patients r
Autor:
Julia E. McGuinness, Tarsha Jones, Elana Levinson, Donna Russo, Wendy K. Chung, Carrie Koval, Ilana Chilton, Meghna S. Trivedi, Boya Guo, Roshni Rao
Publikováno v:
Cancer Research. 80:P6-08
Background: Contralateral prophylactic mastectomy (CPM) is a risk-reducing surgery offered to women with unilateral breast cancer intended to reduce the risk of contralateral breast cancer. The rate of CPM among women with unilateral early-stage brea
Autor:
Thomas Silverman, Meghna S. Trivedi, Katherine D. Crew, Vicky Ro, Julia E. McGuinness, Wendy K. Chung, Rita Kukafka, Tarsha Jones
Publikováno v:
Cancer Research. 81:PS8-08
Introduction Current guidelines for cancer risk management for hereditary breast cancer focus on individuals with pathogenic/likely pathogenic variants (P/LP) in high penetrance genes. There is little consensus on prophylactic mastectomy for low/mode
Autor:
Mohamed Kahila, Stacy W. Blain, Julia E. McGuinness, Jonathan Somma, Kevin Kalinsky, Bachar Samra, Matthew Ingham, Susan R.S. Gottesman, Elina Tress, Steve Xie, Evelyn Taiwo, Gary K. Schwartz, Hanina Hibshoosh, Vladislav Tsiperson
Publikováno v:
Cancer Research. 79:LB-224
PURPOSE: Cdk4 inhibitors (CDK4i), such as palbociclib, are approved in combination with hormonal therapy as a front line treatment for metastatic HR+, Her2- breast cancer. However, despite these advances, many patients demonstrate either de novo or a
Autor:
Meghna S. Trivedi, Julia E. McGuinness, Jennifer Vargas, Raven David, Alejandro Vanegas, Katherine D. Crew, Rita Kukafka, Rossy Sandoval, William Ueng, Katherine Infante, Hae Seung Yi
Publikováno v:
Cancer Research. 76:1790-1790
Objective - High rates of screening mammography have been reported among Hispanic women in the U.S. However, a potential harm of screening is a false positive result with recall breast imaging or biopsy. Our objective was to identify factors associat